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MeSH Review

Wasting Syndrome

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Disease relevance of Wasting Syndrome

  • Consequently, activation of the TNF system by the acid-labile IFN-alpha contributes to some of the physiological disturbances, such as the wasting syndrome, and to the pathophysiology of sepsis in AIDS patients [1].
  • Toxicity from 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure results in severe metabolic imbalances leading to a loss of fat stores in many animal species, a phenomenon known as the wasting syndrome [2].
  • In the allogeneic or semiallogeneic combinations, the BCG treatment resulted in a wasting syndrome and CML/MLC reactivity toward C3H or (C3H X B6)F1 host-derived cells irrespective of thymic presence or absence [3].
  • Transgenic mice that express human TNF mRNA in T cells develop marked histologic and cellular changes locally in their lymphoid organs and a lethal wasting syndrome associated with widespread vascular thrombosis and tissue necrosis [4].
  • In contrast, the Th2-polarized IL-10/IL-12-deficient mice developed a progressive wasting disease that correlated with increased hepatic fibrosis, formation of large eosinophil-rich granulomas, a 10-fold increase in IL-4 and IL-13, and significant mortality during the chronic stages of infection [5].

High impact information on Wasting Syndrome

  • By approximately three weeks of age, most remaining Ptprs-/- mice died from a wasting syndrome with atrophic intestinal villi [6].
  • Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease usually resulting in death of patients by their early twenties [7].
  • Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death [8].
  • In each model, abnormal reconstitution of the T cell compartment in immunodeficient mice by adoptive cell transfer leads to a wasting syndrome and inflammation of the colon, induced by IFN-gamma and tumor necrosis factor (TNF)-alpha-producing T cells [9].
  • This phenomenon could explain the lpr-induced wasting syndrome observed when lpr bone marrow-derived cells are adoptively transferred to wild-type recipients [10].

Chemical compound and disease context of Wasting Syndrome


Biological context of Wasting Syndrome


Anatomical context of Wasting Syndrome


Gene context of Wasting Syndrome


Analytical, diagnostic and therapeutic context of Wasting Syndrome


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  2. 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes reduction of glucose transporting activities in the plasma membranes of adipose tissue and pancreas from the guinea pig. Enan, E., Liu, P.C., Matsumura, F. J. Biol. Chem. (1992) [Pubmed]
  3. Role of the thymus in control of autoreactivity or allotolerance in syngeneic and allogeneic bone marrow chimeras treated with bacterial adjuvants. Taniguchi, K., Gondo, H., Nomoto, K. J. Immunol. (1984) [Pubmed]
  4. Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes. Probert, L., Keffer, J., Corbella, P., Cazlaris, H., Patsavoudi, E., Stephens, S., Kaslaris, E., Kioussis, D., Kollias, G. J. Immunol. (1993) [Pubmed]
  5. IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. Hoffmann, K.F., Cheever, A.W., Wynn, T.A. J. Immunol. (2000) [Pubmed]
  6. Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma. Wallace, M.J., Batt, J., Fladd, C.A., Henderson, J.T., Skarnes, W., Rotin, D. Nat. Genet. (1999) [Pubmed]
  7. Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice. Rafael, J.A., Tinsley, J.M., Potter, A.C., Deconinck, A.E., Davies, K.E. Nat. Genet. (1998) [Pubmed]
  8. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Shull, M.M., Ormsby, I., Kier, A.B., Pawlowski, S., Diebold, R.J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D. Nature (1992) [Pubmed]
  9. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. Simpson, S.J., Shah, S., Comiskey, M., de Jong, Y.P., Wang, B., Mizoguchi, E., Bhan, A.K., Terhorst, C. J. Exp. Med. (1998) [Pubmed]
  10. Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. Chu, J.L., Ramos, P., Rosendorff, A., Nikolić-Zugić, J., Lacy, E., Matsuzawa, A., Elkon, K.B. J. Exp. Med. (1995) [Pubmed]
  11. Effects of thalidomide on HIV-associated wasting syndrome: a randomized, double-blind, placebo-controlled clinical trial. Reyes-Terán, G., Sierra-Madero, J.G., Martínez del Cerro, V., Arroyo-Figueroa, H., Pasquetti, A., Calva, J.J., Ruiz-Palacios, G.M. AIDS (1996) [Pubmed]
  12. Mechanisms of androgen deficiency in human immunodeficiency virus-infected women with the wasting syndrome. Grinspoon, S., Corcoran, C., Stanley, T., Rabe, J., Wilkie, S. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  13. Serum hormones in men with human immunodeficiency virus-associated wasting. Dobs, A.S., Few, W.L., Blackman, M.R., Harman, S.M., Hoover, D.R., Graham, N.M. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  14. Abnormal expression of lysosomal cysteine proteinases in muscle wasting diseases. Katunuma, N., Kominami, E. Rev. Physiol. Biochem. Pharmacol. (1987) [Pubmed]
  15. Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells. Ohsumi, J., Sakakibara, S., Yamaguchi, J., Miyadai, K., Yoshioka, S., Fujiwara, T., Horikoshi, H., Serizawa, N. Endocrinology (1994) [Pubmed]
  16. Open reading frame 2 of porcine circovirus type 2 encodes a major capsid protein. Nawagitgul, P., Morozov, I., Bolin, S.R., Harms, P.A., Sorden, S.D., Paul, P.S. J. Gen. Virol. (2000) [Pubmed]
  17. Hyponatraemia secondary to cerebral salt wasting syndrome following routine pituitary surgery. Atkin, S.L., Coady, A.M., White, M.C., Mathew, B. Eur. J. Endocrinol. (1996) [Pubmed]
  18. Toxic effects of nonadecafluoro-n-decanoic acid in rats. George, M.E., Andersen, M.E. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  19. Hepatic vitamin a depletion is a sensitive marker of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in four rodent species. Fletcher, N., Hanberg, A., Håkansson, H. Toxicol. Sci. (2001) [Pubmed]
  20. T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell-deficient mice. Dohi, T., Fujihashi, K., Koga, T., Shirai, Y., Kawamura, Y.I., Ejima, C., Kato, R., Saitoh, K., McGhee, J.R. Gastroenterology (2003) [Pubmed]
  21. A major role for the Fas pathway in acute graft-versus-host disease. Via, C.S., Nguyen, P., Shustov, A., Drappa, J., Elkon, K.B. J. Immunol. (1996) [Pubmed]
  22. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the "adipose- type" and "brain-type" glucose transporters in mice. Liu, P.C., Matsumura, F. Mol. Pharmacol. (1995) [Pubmed]
  23. Analysis of body water compartments in relation to tissue depletion in clinically stable patients with chronic obstructive pulmonary disease. Baarends, E.M., Schols, A.M., van Marken Lichtenbelt, W.D., Wouters, E.F. Am. J. Clin. Nutr. (1997) [Pubmed]
  24. Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody. Zhu, B., Beaudette, B.C., Rifkin, I.R., Marshak-Rothstein, A. Eur. J. Immunol. (2000) [Pubmed]
  25. Dystrophin and utrophin influence fiber type composition and post-synaptic membrane structure. Rafael, J.A., Townsend, E.R., Squire, S.E., Potter, A.C., Chamberlain, J.S., Davies, K.E. Hum. Mol. Genet. (2000) [Pubmed]
  26. Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactions. Liu, Z., Geboes, K., Colpaert, S., Overbergh, L., Mathieu, C., Heremans, H., de Boer, M., Boon, L., D'Haens, G., Rutgeerts, P., Ceuppens, J.L. J. Immunol. (2000) [Pubmed]
  27. Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice. Wu, X., Chen, L., Brown, C.A., Yan, C., Matzuk, M.M. Mol. Endocrinol. (2004) [Pubmed]
  28. Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice. Cipriano, S.C., Chen, L., Kumar, T.R., Matzuk, M.M. Endocrinology (2000) [Pubmed]
  29. Anti-interleukin-6 therapy for Crohn's disease. Ito, H. Curr. Pharm. Des. (2003) [Pubmed]
  30. MRL/lpr-->severe combined immunodeficiency mouse allografts produce autoantibodies, acute graft-versus-host disease or a wasting syndrome depending on the source of cells. Ashany, D., Hines, J.J., Gharavi, A.E., Mouradian, J., Drappa, J., Elkon, K.B. Clin. Exp. Immunol. (1992) [Pubmed]
  31. In-situ hybridization for the detection of porcine circovirus in pigs with postweaning multisystemic wasting syndrome. Choi, C., Chae, C. J. Comp. Pathol. (1999) [Pubmed]
  32. HLA class I-, complement C4- and 21-hydroxylase probes in the genetic analysis of 21-hydroxylase deficiency. Kochhan, L., Janssen, S., Knorr, D., Olek, K., Bidlingmaier, F. J. Clin. Chem. Clin. Biochem. (1990) [Pubmed]
  33. Impact of highly active antiretroviral therapy on organ-specific manifestations of HIV-1 infection. Torre, D., Speranza, F., Martegani, R. HIV Med. (2005) [Pubmed]
  34. Detection of porcine circovirus type 2, porcine parvovirus and porcine pseudorabies virus from pigs with postweaning multisystemic wasting syndrome by multiplex PCR. Cao, S., Chen, H., Zhao, J., Lü, J., Xiao, S., Jin, M., Guo, A., Wu, B., He, Q. Vet. Res. Commun. (2005) [Pubmed]
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