Disease relevance of Academies and Institutes

• On March 15, 2005, the U.S. Food and Drug Administration approved temozolomide (Temodar capsules, Schering-Plough Research Institute) for the treatment of adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as maintenance treatment [1].
• We examined 14 East African clinical isolates from the Kenya Trypanosomiasis Research Institute strain bank plus 2 established isolates for susceptibility to DL-alpha-difluoromethylornithine and to standard trypanocides [2].
• Centchroman (CC)--a contraceptive and a candidate drug for breast cancer has been developed by the Central Drug Research Institute. It has been successfully marketed as a contraceptive for last several years [3].
• A phase I/II trial of HIV SF2 gp120/MF59 vaccine in seronegative thais.AFRIMS-RIHES Vaccine Evaluation Group. Armed Forces Research Institute of Medical Sciences and the Research Institute for Health Sciences [4].
• We assessed combinations of azithromycin and quinine against uncomplicated P. falciparum malaria at the Armed Forces Research Institute of Medical Sciences-Kwai River Clinical Center along the Thailand-Myanmar border, an area with a high prevalence of multidrug-resistant P. falciparum [5].

Psychiatry related information on Academies and Institutes

• With consultations having been held across Australia this year as part of the process of developing a new National Alcohol Strategy, it seemed timely to invite my colleagues from the National Drug Research Institute who are experts in the alcohol field to write this Harm Reduction Digest [6].
• Of the 75 patients in the February 1977 "class" at the Longevity Research Institute, Santa Barbara, California, 11 volunteers were pre- and posttested (21- to 23-day intervals) with the MMPI, 13 with the California Psychological Inventory, and 17 with four subtests of the WAIS (total: 21 males, 10 females) [7].
• He is currently employed as a consultant to the Mental Health Research Institute at Royal Park Melbourne [8].

High impact information on Academies and Institutes

• MRC attacks government proposal to sell off research institutes [9].
• PURPOSE: N-(4-hydroxyphenyl) retinamide (¿4-HPR, Fenretinide; R.W. Johnson Pharmaceutical Research Institute, Springhouse, PA) and tamoxifen (TAM) have synergistic antitumor and chemopreventive activity against mammary cancer in preclinical studies [10].
• In the past, research at Southern Research Institute led to the development of two new classes of clinically useful anticancer agents, the nitrosoureas and the imidazole triazines [11].
• It has recently been reported (Horwitz, K. B., Zava, D. T., Thilagar, A. K., Jensen, E. M., and McGuire, W. L. (1978) Cancer Res. 38, 2434-2437) than the human breast cancer-derived cell line MCF-7 from EG&G Mason Research Institute contains no 8 S and very little 4 S cytoplasmic estrogen receptor [12].
• Lee Moffitt Cancer Center and Research Institute, a 162-bed tertiary care cancer center specialty hospital affiliated with the University of South Florida College of Medicine, Tampa. Medical records were reviewed for age, sex, histologic findings of previous malignant growth, types and duration of symptoms, and mode of presentation [13].

Chemical compound and disease context of Academies and Institutes

• Quinfamide, a dichloroacetyl quinolol synthesized and tested at Sterling Winthrop Research Institute, is a potent luminal amebicide with potential utility for a one-day treatment of chronic and subacute amebiasis caused by Entamoeba histolytica [14].
• SETTING: Research Institute of Public Health, University of Kuopio, Kuopio, Finland. DESIGN: Prospective study in a cohort of 734 men aged 46-64 y examined in 1991-1993 as part of the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) and followed for 5 y and 3 months [15].
• The financial impact of use of cypermethrin pour-on (Ectopor(R)) in control of animal trypanosomiosis was determined in a trial undertaken by the Kenya Trypanosomiasis Research Institute (KETRI) [16].
• This study conducted at the Research Institute for Tropical Medicine from April 1990 to December 1992, identified the etiology of acute lower respiratory tract infection (ALRI) in 119 (36.9%) of 317 hospitalized children < 5 years of age [17].
• The authors report their results of treatment in patients with ovarian carcinoma (stages III and IV, FIGO classification) with the cytostatic Penberol (cis-beta-4-pentoxybenzoyl-beta-bromoacrylic acid), synthesized at the Research Institute for Pharmacy and Biochemistry in Prague. The present communication links on the paper published in 1980 [18].

Biological context of Academies and Institutes

• Experiments with WR-1065 were performed with stationary cultures of C3H/10T1/2 cells, and a TRIGA reactor-generated fission neutron field at the Armed Forces Radiobiology Research Institute (USA) [19].
• SETTING: Cellular immunology laboratory in a research institute, a high technology IVF unit in a medical center, and a university hospital [20].
• SETTING: Private practice of one surgeon (GAV), and Department of Obstetrics and Gynecology, Lawson Research Institute, St [21].
• The fatty acid composition and total fatty acid content of seeds from 36 blackcurrant genotypes developed at the Scottish Crop Research Institute were examined [22].
• Biotechnology in Japan 1984--a mini-review. Part 2: Government agencies, universities and research institutes [23].

Anatomical context of Academies and Institutes

• The principle of the therapy of carcinoma cervicis uteri in the Research Institute of Clinical and Experimental Oncology in Brno is the combination of betatron megavoltage irradiation and cobalt 60 irradiation with intracavital radium irradiation [24].
• The Multiple Risk Factor Intervention Trial, the Lifestyle Heart Trial, and the Aerobics Research Institute studies suggest that light to moderate amounts of exercise protect against early mortality from coronary artery disease [25].

Associations of Academies and Institutes with chemical compounds

• DL-Centchroman (67/20; INN: Ormeloxifene) synthesized at the Central Drug Research Institute, Lucknow, is a nonsteroidal once-a-week oral contraceptive [26].
• Predictive pharmacophore models were developed for a large series of piperidine- and piperazine-based CCR5 antagonists as anti-HIV-1 agents reported by Schering-Plough Research Institute in recent years [27].
• Acute (10 days) and chronic (360 days after implantation) tissue reaction was characterized numerically and compared with poly(2-hydroxyethyl methacrylate), used in the Drug Control Research Institute in Prague as a standard in the evaluation of polymers, for which good tolerance in the clinical practice has been demonstrated [28].
• The Kronos longevity research institute [29].
• METHODS: Fifty-two patients with an average age of 62 years (range 40-74 years) were sized for both a CarboMedics Top Hat valve (CarboMedics Inc, Austin, Tex) and an MCRI On-X valve (Medical Carbon Research Institute, LLC, Austin, Tex) before random assignment to receive either valve type [30].

Gene context of Academies and Institutes

• A total of 140,000 synthetic compounds from the Bristol-Myers Pharmaceutical Research Institute chemical deck were tested, using a substrate-based colorimetric enzymatic assay, in which ST3 activity was evaluated through its ability to cleave and inactivate alpha-1 proteinase inhibitor [31].
• CEA antigen obtained by the Wrocław team and CEA standard antigen from Chester Beatty Cancer Research Institute, London were used for immunization of goats [32].
• From December 1987 to July 1988, a total of 17,142 clinical specimens were examined at the National Research Institute of Health (NRIH), Addis Abeba, to determine the incidence of methicillin resistant S. aureus (MRSA) strains [33].
• The Melbourne Neuromuscular Research Institute (MNRI) has undertaken diagnostic detection of selected mtDNA mutations since 1990 [34].
• To date, tipifarnib (Zarnestra; Janssen Pharmaceutica NV) and lonafarnib (Sarasar; Schering-Plough Research Institute) are the only two FT inhibitors to have been evaluated in phase III clinical trials [35].

Analytical, diagnostic and therapeutic context of Academies and Institutes

• Ceronapril is a member of a new chemical class of angiotensin-converting enzyme inhibitors being developed by The Bristol-Myers Squibb Pharmaceutical Research Institute. A radioimmunoassay (RIA) has been developed for the measurement of ceronapril in biological fluids [36].
• The computer laboratory of the Research Institute for the Care of Mother and Child in Prague performs annually a countrywide analysis of perinatal outcome in order to obtain a background for the preparation of the optimal strategy for improving perinatal care in CSR in the future [37].
• Past, present, and future of total artificial heart development at research institute of replacement medicine, Hiroshima University School of Medicine [38].
• METHODS: To test the role of LPS in spontaneous and cytokine-boosted abortions, recombinant TNF-alpha + IFN-gamma, and LPS were injected in different doses and sequences intraperitoneally (i.p.) into CBA x DBA/2 mated mice in the Toronto General Research Institute animal facility where the endogenous abortion rate is <30% [39].

References