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Chemical Compound Review

HOMOCYSTINE     2-amino-4-(3-amino-3- carboxy...

Synonyms: L-Homocystine, DL-Homocystine, AGN-PC-005LJL, CHEMBL212056, ACMC-1B5CO, ...
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Disease relevance of HOMOCYSTINE


Psychiatry related information on HOMOCYSTINE

  • These data, despite the relatively small numbers, suggest that early treatment with good biochemical control (lifetime plasma free homocystine median < 11 micromol/L) seems to prevent mental retardation [5].

High impact information on HOMOCYSTINE


Chemical compound and disease context of HOMOCYSTINE


Biological context of HOMOCYSTINE


Anatomical context of HOMOCYSTINE

  • There is considerable evidence that homocystine has a direct damaging effect on vascular endothelium and other tissues [19].
  • These results suggest that dietary homocystine changes the distribution of body water and that sulfur amino acids can affect membrane porosity and/or membrane thickness [20].
  • Homocysteine and homocystine were without effect on the synthesis of vascular PGI2 by umbilical artery segments [control, 0.22 +/- 0.03 to 0.21 +/- 0.03 ng/mg with D,L-homocysteine and 0.20 +/- 0.04 control to 0.19 +/- 0.04 ng/mg with D,L-homocystine] [21].
  • In myocytes superfused with 500 microM homocystine, maximum I(to) density was decreased by approximately 40% from baseline (P < 0.05) [22].
  • The total number of platelets that adhere to confluent monolayers increases for heterozygote cells cultured in the presence of methionine to 0.98 X 10(7) platelets cm-2 (normal cells, range: 0.56-0.72 X 10(7) platelets cm-2) and in the presence of homocystine to 1.41 X 10(7) platelets cm-2 (normal cells, range: 0.94-1.06 X 10(7) platelets cm-2) [15].

Associations of HOMOCYSTINE with other chemical compounds


Gene context of HOMOCYSTINE

  • Oxidized forms of Hcy (Hcy thiolactone, homocystine) were less effective in affecting AP-1 [26].
  • Vitamin B12 injections normalized her fasting homocystine level and her MCV [14].
  • Homocystine treatment did not cause significant alterations in CBS levels (P=0.992) [3].
  • Plasma levels of fibrinogen and homocystine and serum levels of plasminogen activator inhibitor-1 (PAI-1) were obtained before and 6 months after initiation of treatment [27].
  • AIM OF THE STUDY: The aim of this study was to determine if homocystine would augment VPA-induced exencephaly in an experimental model [12].

Analytical, diagnostic and therapeutic context of HOMOCYSTINE


  1. Response to injury and atherogenesis. Ross, R., Glomset, J., Harker, L. Am. J. Pathol. (1977) [Pubmed]
  2. Homocystine, atherosclerosis and thrombosis: implications for oral contraceptive users. McCully, K.S. Am. J. Clin. Nutr. (1975) [Pubmed]
  3. Increasing levels of dietary homocystine with carotid endarterectomy produced proportionate increases in plasma homocysteine and intimal hyperplasia. Southern, F., Eidt, J., Drouilhet, J., Mukunyadzi, P., Williams, D.K., Cruz, C., Wang, Y.F., Poirier, L.A., Brown, A.T., Moursi, M.M. Atherosclerosis (2001) [Pubmed]
  4. Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. Pianka, P., Almog, Y., Man, O., Goldstein, M., Sela, B.A., Loewenstein, A. Ophthalmology (2000) [Pubmed]
  5. The intellectual abilities of early-treated individuals with pyridoxine-nonresponsive homocystinuria due to cystathionine beta-synthase deficiency. Yap, S., Rushe, H., Howard, P.M., Naughten, E.R. J. Inherit. Metab. Dis. (2001) [Pubmed]
  6. Platelet survival and morphology in homocystinuria due to cystathionine synthase deficiency. Uhlemann, E.R., TenPas, J.H., Lucky, A.W., Schulman, J.D., Mudd, S.H., Shulman, N.R. N. Engl. J. Med. (1976) [Pubmed]
  7. Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis. Harker, L.A., Ross, R., Slichter, S.J., Scott, C.R. J. Clin. Invest. (1976) [Pubmed]
  8. Methionine intolerance: a possible risk factor for coronary artery disease. Murphy-Chutorian, D.R., Wexman, M.P., Grieco, A.J., Heininger, J.A., Glassman, E., Gaull, G.E., Ng, S.K., Feit, F., Wexman, K., Fox, A.C. J. Am. Coll. Cardiol. (1985) [Pubmed]
  9. Recurrent dystonia in homocystinuria: A metabolic pathogenesis. Sinclair, A.J., Barling, L., Nightingale, S. Mov. Disord. (2006) [Pubmed]
  10. Isotachophoretic analyses of cystine, homocystine and cystathionine in urines from patients with inborn errors of metabolism. Mizobuchi, N., Ageta, T., Sasaki, K., Kodama, H. J. Chromatogr. (1986) [Pubmed]
  11. Saratin (an inhibitor of platelet-collagen interaction) decreases platelet aggregation and homocysteine-mediated postcarotid endarterectomy intimal hyperplasia in a dose-dependent manner. Davis, J.A., Brown, A.T., Alshafie, T., Poirier, L.A., Cruz, C.P., Wang, Y., Eidt, J.F., Moursi, M.M. Am. J. Surg. (2004) [Pubmed]
  12. Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos. Padmanabhan, R., Shafiullah, M., Benedict, S., Nagelkerke, N. European journal of nutrition. (2006) [Pubmed]
  13. Effect of clopidogrel on platelet aggregation and intimal hyperplasia following carotid endarterectomy in the rat. Bledsoe, S.L., Brown, A.T., Davis, J.A., Chen, H., Eidt, J.F., Moursi, M.M. Vascular. (2005) [Pubmed]
  14. Ischemic strokes secondary to vitamin B12 deficiency-induced hyperhomocystinemia. Penix, L.P. Neurology (1998) [Pubmed]
  15. Endothelial cell dysfunction in homocystinuria. de Groot, P.G., Willems, C., Boers, G.H., Gonsalves, M.D., van Aken, W.G., van Mourik, J.A. Eur. J. Clin. Invest. (1983) [Pubmed]
  16. Vitamin B12 and folate after 5-12 years of continent ileal urostomy (Kock reservoir) in children and adolescents. Abd-el-Gawa, G., Abrahamsson, K., Norlén, L., Hjälmås, K., Hanson, E. Eur. Urol. (2002) [Pubmed]
  17. Reduction-oxidation (Redox) and vascular tissue level of homocyst(e)ine in human coronary atherosclerotic lesions and role in extracellular matrix remodeling and vascular tone. Tyagi, S.C., Smiley, L.M., Mujumdar, V.S., Clonts, B., Parker, J.L. Mol. Cell. Biochem. (1998) [Pubmed]
  18. Homocysteine redox receptor and regulation of extracellular matrix components in vascular cells. Tyagi, S.C. Am. J. Physiol. (1998) [Pubmed]
  19. The effect of D-penicillamine on protein-bound homocyst(e)ine in homocystinurics. Kang, S.S., Wong, P.W., Curley, K. Pediatr. Res. (1982) [Pubmed]
  20. Use of bioimpedance spectroscopy to estimate body water distribution in rats fed high dietary sulfur amino acids. Yokoi, K., Lukaski, H.C., Uthus, E.O., Nielsen, F.H. J. Nutr. (2001) [Pubmed]
  21. Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism. Graeber, J.E., Slott, J.H., Ulane, R.E., Schulman, J.D., Stuart, M.J. Pediatr. Res. (1982) [Pubmed]
  22. Inhibition of K+ currents by homocysteine in rat ventricular myocytes. Shontz, R.D., Xu, Z., Patel, K.P., Rozanski, G.J. J. Cardiovasc. Electrophysiol. (2001) [Pubmed]
  23. Effects of dietary folic acid supplementation on cerebrovascular endothelial dysfunction in rats with induced hyperhomocysteinemia. Lee, H., Kim, H.J., Kim, J.M., Chang, N. Brain Res. (2004) [Pubmed]
  24. Urinary homocystine levels in a newborn infant with cystathionine synthase deficiency. Watanabe, T., Kuroda, Y., Naito, E., Ito, M., Takeda, E., Toshima, K., Miyao, M., Tomita, T., Furukawa, S. Eur. J. Pediatr. (1987) [Pubmed]
  25. Conversion of a qualitative screening test to a quantitative measurement of urinary cystine and homocystine. Wu, J.T., Wilson, L.W., Christensen, S. Ann. Clin. Lab. Sci. (1992) [Pubmed]
  26. Homocysteine exerts cell type-specific inhibition of AP-1 transcription factor. Suzuki, Y.J., Lorenzi, M.V., Shi, S.S., Day, R.M., Blumberg, J.B. Free Radic. Biol. Med. (2000) [Pubmed]
  27. The impact of third-generation beta-blocker antihypertensive treatment on endothelial function and the prothrombotic state: effects of smoking. Vyssoulis, G.P., Marinakis, A.G., Aznaouridis, K.A., Karpanou, E.A., Arapogianni, A.N., Cokkinos, D.V., Stefanadis, C.I. Am. J. Hypertens. (2004) [Pubmed]
  28. Experimental homocystinemia, endothelial lesions and thrombosis. Hladovec, J. Blood vessels. (1979) [Pubmed]
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