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Chemical Compound Review

Herbadox     3,4-dimethyl-2,6-dinitro-N- pentan-3-yl...

Synonyms: Pendimax, Accotab, Penoxalin, Penoxyn, Sipaxol, ...
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Disease relevance of Sipaxol


High impact information on Sipaxol


Chemical compound and disease context of Sipaxol


Biological context of Sipaxol

  • Results indicate that specific growth rate, cell number, chlorophyll a level, and dry weight yield significantly decrease with increasing pendimethalin concentrations, while protein and carbohydrate contents increase significantly [11].
  • The most active compound was pendimethalin with an IC50 of 0.19 microM while nitralin was the least active with an IC50 of 4.5 microM [12].
  • Fungal decomposition of pendimethalin involved nitro reduction and dealkylation [13].

Anatomical context of Sipaxol


Associations of Sipaxol with other chemical compounds


Gene context of Sipaxol


Analytical, diagnostic and therapeutic context of Sipaxol

  • Analysis of pendimethalin residues in fruit, nuts, vegetables, grass, and mint by gas chromatography [18].
  • The influence of soil-water ratio was studied on the performance of the slurry phase bioreactor operated in sequencing batch mode (anoxic-aerobic-anoxic microenvironments) during the bioremediation of soil contaminated with pendimethalin [19].


  1. Pendimethalin exposure and cancer incidence among pesticide applicators. Hou, L., Lee, W.J., Rusiecki, J., Hoppin, J.A., Blair, A., Bonner, M.R., Lubin, J.H., Samanic, C., Sandler, D.P., Dosemeci, M., Alavanja, M.C. Epidemiology (Cambridge, Mass.) (2006) [Pubmed]
  2. Comparative genotoxicity of the herbicides Roundup, Stomp and Reglone in plant and mammalian test systems. Dimitrov, B.D., Gadeva, P.G., Benova, D.K., Bineva, M.V. Mutagenesis (2006) [Pubmed]
  3. Toxicity of pendimethalin to nontarget soil organisms. Belden, J.B., Phillips, T.A., Clark, B.W., Coats, J.R. Bulletin of environmental contamination and toxicology. (2005) [Pubmed]
  4. In vitro detoxification of pendimethalin by two Actinomycetes spp. Gopal, M., Jha, S.K., Shukla, L., Rawat, R.V. Bulletin of environmental contamination and toxicology. (2005) [Pubmed]
  5. Decay of dinitroaniline herbicides and organophosphorus insecticides during brewing of lager beer. Navarro, S., Pérez, G., Navarro, G., Mena, L., Vela, N. J. Food Prot. (2006) [Pubmed]
  6. Transgenic rice containing human CYP2B6 detoxifies various classes of herbicides. Hirose, S., Kawahigashi, H., Ozawa, K., Shiota, N., Inui, H., Ohkawa, H., Ohkawa, Y. J. Agric. Food Chem. (2005) [Pubmed]
  7. Effect of prairie grass on the dissipation, movement, and bioavailability of selected herbicides in prepared soil columns. Belden, J.B., Phillips, T.A., Coats, J.R. Environ. Toxicol. Chem. (2004) [Pubmed]
  8. Influence of organic fertilizer application on pendimethalin volatilization and persistence in soil. García-Valcárcel, A.I., Tadeo, J.L. J. Agric. Food Chem. (2003) [Pubmed]
  9. Clinical experience with pendimethalin (STOMP) poisoning in Taiwan. Chuang, C.C., Wang, S.T., Yang, C.C., Deng, J.F. Veterinary and human toxicology. (1998) [Pubmed]
  10. Formation of tomatine in tomato plants infected with Streptomyces species and treated with herbicides, correlated with reduction of Pseudomonas solanacearum and Fusarium oxysporum f. sp. lycopersici. El-Raheem, A., El-Shanshoury, R., El-Sououd, S.M., Awadalla, O.A., El-Bandy, N.B. Acta Microbiol. Pol. (1995) [Pubmed]
  11. Effect of pendimethalin on growth and photosynthetic activity of Protosiphon botryoides in different nutrient states. Shabana, E.F., Battah, M.G., Kobbia, I.A., Eladel, H.M. Ecotoxicol. Environ. Saf. (2001) [Pubmed]
  12. In vitro anticryptosporidial activity of dinitroaniline herbicides. Arrowood, M.J., Mead, J.R., Xie, L., You, X. FEMS Microbiol. Lett. (1996) [Pubmed]
  13. Microbial degradation of pendimethalin. Singh, S.B., Kulshrestha, G. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1991) [Pubmed]
  14. In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test. Gebel, T., Kevekordes, S., Pav, K., Edenharder, R., Dunkelberg, H. Arch. Toxicol. (1997) [Pubmed]
  15. Herbicidal cyanoacrylates with antimicrotubule mechanism of action. Tresch, S., Plath, P., Grossmann, K. Pest Manag. Sci. (2005) [Pubmed]
  16. Plasmodium: assessment of the antimalarial potential of trifluralin and related compounds using a rat model of malaria, Rattus norvegicus. Dow, G.S., Armson, A., Boddy, M.R., Itenge, T., McCarthy, D., Parkin, J.E., Thompson, R.C., Reynoldson, J.A. Exp. Parasitol. (2002) [Pubmed]
  17. Activities of mixtures of soil-applied herbicides with different molecular targets. Kaushik, S., Streibig, J.C., Cedergreen, N. Pest Manag. Sci. (2006) [Pubmed]
  18. Analysis of pendimethalin residues in fruit, nuts, vegetables, grass, and mint by gas chromatography. Engebretson, J., Hall, G., Hengel, M., Shibamoto, T. J. Agric. Food Chem. (2001) [Pubmed]
  19. Influence of soil-water ratio on the performance of slurry phase bioreactor treating herbicide contaminated soil. Venkata Mohan, S., Ramakrishna, M., Shailaja, S., Sarma, P.N. Bioresour. Technol. (2007) [Pubmed]
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