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Chemical Compound Review

Treflan     2,6-dinitro-N,N-dipropyl-4...

Synonyms: Agreflan, Commence, Crisalin, Digermin, Treficon, ...
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Disease relevance of Treflan


High impact information on Treflan


Chemical compound and disease context of Treflan


Biological context of Treflan


Anatomical context of Treflan

  • To date no effect of trifluralin on animal microtubule systems has been reported; therefore, it is suggested that trifluralin has revealed a pharmacological difference between plant and animal tubulin [16].
  • The herbicide trifluralin was evaluated for genotoxicity in cultured human peripheral blood lymphocytes [13].
  • The mutagenic effect of trifluralin-containing herbicide on mouse germ cells in vivo [17].
  • The mutagenic effect of trifluralin-containing herbicide on mouse bone marrow in vivo [18].
  • An increase of functional enzyme activities in blood serum and the organs examined, particularly in the highest concentration of trifluralin indicated changes in the vital organs, was confirmed by histological analysis [19].

Associations of Treflan with other chemical compounds


Gene context of Treflan


Analytical, diagnostic and therapeutic context of Treflan


  1. Herbicides to curb human parasitic infections: in vitro and in vivo effects of trifluralin on the trypanosomatid protozoans. Chan, M.M., Grogl, M., Chen, C.C., Bienen, E.J., Fong, D. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Efficacy of the herbicide trifluralin against four P-glycoprotein-expressing strains of Leishmania. Chan, M.M., Grogl, M., Callahan, H., Fong, D. Antimicrob. Agents Chemother. (1995) [Pubmed]
  3. Quantitative structure-activity analysis of the algae toxicity of nitroaromatic compounds. Schmitt, H., Altenburger, R., Jastorff, B., Schüürmann, G. Chem. Res. Toxicol. (2000) [Pubmed]
  4. Allergic contact dermatitis from the herbicides trifluralin and benefin. Pentel, M.T., Andreozzi, R.J., Marks, J.G. J. Am. Acad. Dermatol. (1994) [Pubmed]
  5. Inhibition of leishmanias but not host macrophages by the antitubulin herbicide trifluralin. Chan, M.M., Fong, D. Science (1990) [Pubmed]
  6. Plant microtubule inhibitors against trypanosomatids. Chan, M.M., Fong, D. Parasitol. Today (Regul. Ed.) (1994) [Pubmed]
  7. Binding and interaction of dinitroanilines with apicomplexan and kinetoplastid alpha-tubulin. Mitra, A., Sept, D. J. Med. Chem. (2006) [Pubmed]
  8. In vivo genotoxicity of selected herbicides in the mouse bone-marrow micronucleus test. Gebel, T., Kevekordes, S., Pav, K., Edenharder, R., Dunkelberg, H. Arch. Toxicol. (1997) [Pubmed]
  9. Treatment of experimental chronic chagas disease with trifluralin. Zaidenberg, A., Luong, T., Lirussi, D., Bleiz, J., Del Buono, M.B., Quijano, G., Drut, R., Kozubsky, L., Marron, A., Buschiazzo, H. Basic & clinical pharmacology & toxicology. (2006) [Pubmed]
  10. Effect of some herbicides on the toxicity of certain molluscacides against Biomphalaria alexandrina snails. el-Fiki, S.A., Mohamed, A.M. Egyptian journal of bilharziasis. (1978) [Pubmed]
  11. Meiotic aneuploidy: its origins and induction following chemical treatment in Sordaria brevicollis. Bond, D.J., McMillan, L. Environ. Health Perspect. (1979) [Pubmed]
  12. Trace determination of priority pesticides in water by means of high-speed on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry using turbulent-flow chromatography columns for enrichment and a short monolithic column for fast liquid chromatographic separation. Asperger, A., Efer, J., Koal, T., Engewald, W. Journal of chromatography. A. (2002) [Pubmed]
  13. Genotoxic evaluation of the herbicide trifluralin on human lymphocytes exposed in vitro. Ribas, G., Surrallés, J., Carbonell, E., Xamena, N., Creus, A., Marcos, R. Mutat. Res. (1996) [Pubmed]
  14. Body size and the toxicokinetics of trifluralin in rainbow trout. Schultz, I.R., Hayton, W.L. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  15. Altered tubulin dynamics, localization and post-translational modifications in sodium arsenite resistant Leishmania donovani in response to paclitaxel, trifluralin and a combination of both and induction of apoptosis-like cell death. Jayanarayan, K.G., Dey, C.S. Parasitology (2005) [Pubmed]
  16. Binding of the herbicide trifluralin to Chlamydomonas flagellar tubulin. Hess, F.D., Bayer, D.E. J. Cell. Sci. (1977) [Pubmed]
  17. The mutagenic effect of trifluralin-containing herbicide on mouse germ cells in vivo. Nehéz, M., Páldy, A., Selypes, A., Körösfalvi, M., Lörinczi, I., Berencsi, G. Ecotoxicol. Environ. Saf. (1980) [Pubmed]
  18. The mutagenic effect of trifluralin-containing herbicide on mouse bone marrow in vivo. Nehéz, M., Páldy, A., Selypes, A., Körösfalvi, M., Lörinczi, I., Berencsi, G. Ecotoxicol. Environ. Saf. (1979) [Pubmed]
  19. Effects of trifluralin on carp: biochemical and histological evaluation. Poleksić, V., Karan, V. Ecotoxicol. Environ. Saf. (1999) [Pubmed]
  20. Uptake of trifluralin and lindane from water by ryegrass. Li, H., Sheng, G., Sheng, W., Xu, O. Chemosphere (2002) [Pubmed]
  21. Effects of the antitubulin drug trifluralin on the proliferation and metacyclogenesis of Trypanosoma cruzi epimastigotes. Bogitsh, B.J., Middleton, O.L., Ribeiro-Rodrigues, R. Parasitol. Res. (1999) [Pubmed]
  22. The effects of five weeks treatment with dinitro-o-cresol- or trifluralin-containing pesticides on the germ cells of male mice. Nehéz, M., Selypes, A., Páldy, A., Mazzag, E., Berencsi, G., Jármay, K. Journal of applied toxicology : JAT. (1982) [Pubmed]
  23. Kinetics and hydrolysis of fenamiphos, fipronil, and trifluralin in aqueous buffer solutions. Ramesh, A., Balasubramanian, M. J. Agric. Food Chem. (1999) [Pubmed]
  24. The effect of structurally divergent herbicides on mouse liver xenobiotic-metabolizing enzymes (P-450-dependent mono-oxygenases, epoxide hydrolases and glutathione S-transferases) and carnitine acetyltransferase. Moody, D.E., Narloch, B.A., Shull, L.R., Hammock, B.D. Toxicol. Lett. (1991) [Pubmed]
  25. Using 19F NMR spectroscopy to determine trifluralin binding to soil. Strynar, M., Dec, J., Benesi, A., Jones, A.D., Fry, R.A., Bollag, J.M. Environ. Sci. Technol. (2004) [Pubmed]
  26. Simultaneous determination of linuron and trifluralin residues in carrots and their pulp by liquid chromatography and gas chromatography. D'Amato, A., Semeraro, I., Bicchi, C. Journal of AOAC International. (1993) [Pubmed]
  27. Transradial coronary angioplasty and stent implantation in acute myocardial infarction: initial experience. Mathias, D.W., Bigler, L. The Journal of invasive cardiology. (2000) [Pubmed]
  28. An alternative supercritical fluid extraction system for aqueous matrices and its application in pesticides residue analysis. De Martinis, B.S., Lanças, F.M. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (2000) [Pubmed]
  29. Efficacy of postdeployment balloon dilatation for current generation stents as assessed by intravascular ultrasound. Hur, S.H., Kitamura, K., Morino, Y., Honda, Y., Jones, M., Korr, K.S., Reen, B., Cooper, C.J., Niess, G.S., Christie, L., Corey, W., Messenger, J., Yock, P.G., Cummins, F., Fitzgerald, P.J. Am. J. Cardiol. (2001) [Pubmed]
  30. Determination of benefin and trifluralin residues by quantitative gas-liquid chromatography/mass spectrometry. Downer, G.B., Hall, M., Mallen, D.N. J. Agric. Food Chem. (1976) [Pubmed]
  31. Mortality response and LC50 values for juvenile and adult crayfish, Procambarus clarkii exposed to Thiodan (insecticide), Treflan, MSMA, Oust (herbicides) and Cutrine-Plus (algicide). Naqvi, S.M., Hawkins, R., Naqvi, N.H. Environ. Pollut. (1987) [Pubmed]
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