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Chemical Compound Review

Lumazine     1H-pteridine-2,4-dione

Synonyms: Lumazin, Lumazine (VAN), L3307_ALDRICH, SureCN321932, SureCN932546, ...
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Disease relevance of Lumazine

  • A library of Photobacterium phosphoreum DNA was screened in lambda 2001 for the lumazine protein gene, using two degenerate 17-mer oligonucleotide probes that were deduced from a partial protein primary sequence [1].
  • Considerable sequence similarity was detected between lumazine protein, the yellow fluorescence protein from Vibrio fischeri, and the alpha subunit of riboflavin synthetase (EC [1].
  • Substrate channeling in the lumazine synthase/riboflavin synthase complex of Bacillus subtilis [2].
  • High order quaternary arrangement confers increased structural stability to Brucella sp. lumazine synthase [3].
  • The lumazine synthase/riboflavin synthase complex of Bacillus subtilis consists of an icosahedral capsid of 60 beta subunits surrounding a core of three alpha subunits [2].

High impact information on Lumazine


Chemical compound and disease context of Lumazine


Biological context of Lumazine


Associations of Lumazine with other chemical compounds


Gene context of Lumazine


Analytical, diagnostic and therapeutic context of Lumazine


  1. Borrowed proteins in bacterial bioluminescence. O'Kane, D.J., Woodward, B., Lee, J., Prasher, D.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Substrate channeling in the lumazine synthase/riboflavin synthase complex of Bacillus subtilis. Kis, K., Bacher, A. J. Biol. Chem. (1995) [Pubmed]
  3. High order quaternary arrangement confers increased structural stability to Brucella sp. lumazine synthase. Zylberman, V., Craig, P.O., Klinke, S., Braden, B.C., Cauerhff, A., Goldbaum, F.A. J. Biol. Chem. (2004) [Pubmed]
  4. Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus. Haase, I., Fischer, M., Bacher, A., Schramek, N. J. Biol. Chem. (2003) [Pubmed]
  5. The lumazine protein gene in Photobacterium phosphoreum is linked to the lux operon. Prasher, D.C., O'Kane, D., Lee, J., Woodward, B. Nucleic Acids Res. (1990) [Pubmed]
  6. Studies on the lumazine synthase/riboflavin synthase complex of Bacillus subtilis: crystal structure analysis of reconstituted, icosahedral beta-subunit capsids with bound substrate analogue inhibitor at 2.4 A resolution. Ritsert, K., Huber, R., Turk, D., Ladenstein, R., Schmidt-Bäse, K., Bacher, A. J. Mol. Biol. (1995) [Pubmed]
  7. Spectroscopic investigations of the single tryptophan residue and of riboflavin and 7-oxolumazine bound to lumazine apoprotein from Photobacterium leiognathi. Kulinski, T., Visser, A.J., O'Kane, D.J., Lee, J. Biochemistry (1987) [Pubmed]
  8. Design, synthesis, and evaluation of 9-D-ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones bearing alkyl phosphate and alpha,alpha-difluorophosphonate substituents as inhibitors of tiboflavin synthase and lumazine synthase. Cushman, M., Sambaiah, T., Jin, G., Illarionov, B., Fischer, M., Bacher, A. J. Org. Chem. (2004) [Pubmed]
  9. Fluorescence study of the ligand stereospecificity for binding to lumazine protein. Lee, J., Gibson, B.G., O'Kane, D.J., Kohnle, A., Bacher, A. Eur. J. Biochem. (1992) [Pubmed]
  10. Dynamic fluorescence study of the interaction of lumazine protein with bacterial luciferases. Lee, J., O'Kane, D.J., Gibson, B.G. Biophys. Chem. (1989) [Pubmed]
  11. Multiple assembly States of lumazine synthase: a model relating catalytic function and molecular assembly. Zhang, X., Konarev, P.V., Petoukhov, M.V., Svergun, D.I., Xing, L., Cheng, R.H., Haase, I., Fischer, M., Bacher, A., Ladenstein, R., Meining, W. J. Mol. Biol. (2006) [Pubmed]
  12. Electronic excitation transfer in the complex of lumazine protein with bacterial bioluminescence intermediates. Lee, J., Wang, Y.Y., Gibson, B.G. Biochemistry (1991) [Pubmed]
  13. (Trifluoromethyl)lumazine derivatives as 19F NMR probes for lumazine protein. Scheuring, J., Lee, J., Cushman, M., Patel, H., Patrick, D.A., Bacher, A. Biochemistry (1994) [Pubmed]
  14. Design, synthesis, and biochemical evaluation of 1,5,6,7-tetrahydro-6,7-dioxo-9-D-ribitylaminolumazines bearing alkyl phosphate substituents as inhibitors of lumazine synthase and riboflavin synthase. Cushman, M., Jin, G., Illarionov, B., Fischer, M., Ladenstein, R., Bacher, A. J. Org. Chem. (2005) [Pubmed]
  15. A high-throughput screen utilizing the fluorescence of riboflavin for identification of lumazine synthase inhibitors. Chen, J., Illarionov, B., Bacher, A., Fischer, M., Haase, I., Georg, G., Ye, Q.Z., Ma, Z., Cushman, M. Anal. Biochem. (2005) [Pubmed]
  16. Enzyme catalysis via control of activation entropy: site-directed mutagenesis of 6,7-dimethyl-8-ribityllumazine synthase. Fischer, M., Haase, I., Kis, K., Meining, W., Ladenstein, R., Cushman, M., Schramek, N., Huber, R., Bacher, A. J. Mol. Biol. (2003) [Pubmed]
  17. Protein-ligand interactions in lumazine protein and in Desulfovibrio flavodoxins from resonance coherent anti-Stokes Raman spectra. Irwin, R.M., Visser, A.J., Lee, J., Carreira, L.A. Biochemistry (1980) [Pubmed]
  18. Molecular probe for selective detection of thiols in water of neutral pH. Kim, D.H., Han, M.S. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  19. FTIR characterization of heterocycles lumazine and violapterin in solution: effects of solvent on anionic forms. Michaud, A.L., Herrick, J.A., Duplain, J.E., Manson, J.L., Hemann, C., Ilich, P., Donohoe, R.J., Hille, R., Oertling, W.A. Biospectroscopy. (1998) [Pubmed]
  20. Effects of several inhibitors on pure cultures of ruminal methanogens. Ungerfeld, E.M., Rust, S.R., Boone, D.R., Liu, Y. J. Appl. Microbiol. (2004) [Pubmed]
  21. Riboflavin synthesis genes are linked with the lux operon of Photobacterium phosphoreum. Lee, C.Y., O'Kane, D.J., Meighen, E.A. J. Bacteriol. (1994) [Pubmed]
  22. In vitro damage to rat lens by lumazine and xanthine oxidase: prevention by superoxide dismutase. Varma, S.D., Bauer, S.A. Free Radic. Res. Commun. (1987) [Pubmed]
  23. The lumazine synthase-riboflavin synthase complex of Bacillus subtilis. Crystallization of reconstituted icosahedral beta-subunit capsids. Schott, K., Ladenstein, R., König, A., Bacher, A. J. Biol. Chem. (1990) [Pubmed]
  24. Biosynthesis of riboflavin. Single turnover kinetic analysis of 6,7-dimethyl-8-ribityllumazine synthase. Schramek, N., Haase, I., Fischer, M., Bacher, A. J. Am. Chem. Soc. (2003) [Pubmed]
  25. Formation of metal nanoclusters on specific surface sites of protein molecules. Braun, N., Meining, W., Hars, U., Fischer, M., Ladenstein, R., Huber, R., Bacher, A., Weinkauf, S., Bachmann, L. J. Mol. Biol. (2002) [Pubmed]
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