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Chemical Compound Review

Thymoquinon     2-methyl-5-propan-2-yl- cyclohexa-2,5-diene...

Synonyms: Thymoquinone, SureCN542535, NSC-2228, CCRIS 7152, AG-B-91274, ...
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Disease relevance of NSC 2228


Psychiatry related information on NSC 2228


High impact information on NSC 2228


Chemical compound and disease context of NSC 2228


Biological context of NSC 2228


Anatomical context of NSC 2228


Associations of NSC 2228 with other chemical compounds


Gene context of NSC 2228


Analytical, diagnostic and therapeutic context of NSC 2228


  1. Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. Al-Majed, A.A., Al-Omar, F.A., Nagi, M.N. Eur. J. Pharmacol. (2006) [Pubmed]
  2. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Gali-Muhtasib, H., Diab-Assaf, M., Boltze, C., Al-Hmaira, J., Hartig, R., Roessner, A., Schneider-Stock, R. Int. J. Oncol. (2004) [Pubmed]
  3. Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping. Aboul-Ela, E.I. Mutat. Res. (2002) [Pubmed]
  4. Androgen receptor and E2F-1 targeted thymoquinone therapy for hormone-refractory prostate cancer. Kaseb, A.O., Chinnakannu, K., Chen, D., Sivanandam, A., Tejwani, S., Menon, M., Dou, Q.P., Reddy, G.P. Cancer Res. (2007) [Pubmed]
  5. Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Hosseinzadeh, H., Parvardeh, S. Phytomedicine (2004) [Pubmed]
  6. Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. El-Mahdy, M.A., Zhu, Q., Wang, Q.E., Wani, G., Wani, A.A. Int. J. Cancer (2005) [Pubmed]
  7. Nonenzymatic reduction of thymoquinone in physiological conditions. Khalife, K.H., Lupidi, G. Free Radic. Res. (2007) [Pubmed]
  8. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Rooney, S., Ryan, M.F. Anticancer Res. (2005) [Pubmed]
  9. Thymoquinone protects against experimental colitis in rats. Mahgoub, A.A. Toxicol. Lett. (2003) [Pubmed]
  10. The effect of conventional and sustained delivery of thymoquinone and levodopa on SH-SY5Y human neuroblastoma cells. Martin, T.M., Benghuzzi, H., Tucci, M. Biomedical sciences instrumentation. (2006) [Pubmed]
  11. Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Tekeoglu, I., Dogan, A., Demiralp, L. Phytotherapy research : PTR. (2006) [Pubmed]
  12. The physiological effect of conventional treatment with epigallocatechin-3-gallate, thymoquinone, and tannic acid on the LNCaP cell line. Richards, L.R., Jones, P., Hughes, J., Benghuzzi, H., Tucci, M. Biomedical sciences instrumentation. (2006) [Pubmed]
  13. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Houghton, P.J., Zarka, R., de las Heras, B., Hoult, J.R. Planta Med. (1995) [Pubmed]
  14. Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Gali-Muhtasib, H.U., Abou Kheir, W.G., Kheir, L.A., Darwiche, N., Crooks, P.A. Anticancer Drugs (2004) [Pubmed]
  15. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Shoieb, A.M., Elgayyar, M., Dudrick, P.S., Bell, J.L., Tithof, P.K. Int. J. Oncol. (2003) [Pubmed]
  16. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Daba, M.H., Abdel-Rahman, M.S. Toxicol. Lett. (1998) [Pubmed]
  17. In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Marsik, P., Kokoska, L., Landa, P., Nepovim, A., Soudek, P., Vanek, T. Planta Med. (2005) [Pubmed]
  18. Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis. Budancamanak, M., Kanter, M., Demirel, A., Ocakci, A., Uysal, H., Karakaya, C. Arch. Toxicol. (2006) [Pubmed]
  19. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. Kanter, M., Coskun, O., Uysal, H. Arch. Toxicol. (2006) [Pubmed]
  20. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Badary, O.A., Al-Shabanah, O.A., Nagi, M.N., Al-Rikabi, A.C., Elmazar, M.M. Eur. J. Cancer Prev. (1999) [Pubmed]
  21. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. Mansour, M., Tornhamre, S. Journal of enzyme inhibition and medicinal chemistry. (2004) [Pubmed]
  22. Improvement of experimental allergic encephalomyelitis (EAE) by thymoquinone; an oxidative stress inhibitor. Mohamed, A., Shoker, A., Bendjelloul, F., Mare, A., Alzrigh, M., Benghuzzi, H., Desin, T. Biomedical sciences instrumentation. (2003) [Pubmed]
  23. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Ghosheh, O.A., Houdi, A.A., Crooks, P.A. Journal of pharmaceutical and biomedical analysis. (1999) [Pubmed]
  24. Crystal structure determination of thymoquinone by high-resolution X-ray powder diffraction. Pagola, S., Benavente, A., Raschi, A., Romano, E., Molina, M.A., Stephens, P.W. AAPS PharmSciTech [electronic resource]. (2004) [Pubmed]
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