Gene Review:
APOH - apolipoprotein H (beta-2-glycoprotein I)
Homo sapiens
Synonyms:
APC inhibitor, Activated protein C-binding protein, Anticardiolipin cofactor, Apo-H, Apolipoprotein H, ...
- Complete DNA sequence variation in the apolipoprotein H (beta-glycoprotein I) gene and identification of informative SNPs. Chen, Q., Kamboh, M.I. Ann. Hum. Genet. (2006)
- Binding of beta 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells. Kuwana, M., Matsuura, E., Kobayashi, K., Okazaki, Y., Kaburaki, J., Ikeda, Y., Kawakami, Y. Blood (2005)
- Valine/valine genotype at position 247 of the beta2-glycoprotein I gene in Mexican patients with primary antiphospholipid syndrome: association with anti-beta2-glycoprotein I antibodies. Prieto, G.A., Cabral, A.R., Zapata-Zuñiga, M., Simón, A.J., Villa, A.R., Alarcón-Segovia, D., Cabiedes, J. Arthritis Rheum. (2003)
- Hepatitis B virus surface antigen binds to apolipoprotein H. Mehdi, H., Kaplan, M.J., Anlar, F.Y., Yang, X., Bayer, R., Sutherland, K., Peeples, M.E. J. Virol. (1994)
- Nucleotide sequence and expression of the human gene encoding apolipoprotein H (beta 2-glycoprotein I). Mehdi, H., Nunn, M., Steel, D.M., Whitehead, A.S., Perez, M., Walker, L., Peeples, M.E. Gene (1991)
- Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome. Blank, M., Krause, I., Fridkin, M., Keller, N., Kopolovic, J., Goldberg, I., Tobar, A., Shoenfeld, Y. J. Clin. Invest. (2002)
- beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin. Moestrup, S.K., Schousboe, I., Jacobsen, C., Leheste, J.R., Christensen, E.I., Willnow, T.E. J. Clin. Invest. (1998)
- Inhibition of activated protein C by platelets. Jane, S.M., Mitchell, C.A., Hau, L., Salem, H.H. J. Clin. Invest. (1989)
- Action of anticardiolipin and antibodies to beta2-glycoprotein-I on trophoblast proliferation as a mechanism for fetal death. Chamley, L.W., Duncalf, A.M., Mitchell, M.D., Johnson, P.M. Lancet (1998)
- Significance of valine/leucine247 polymorphism of beta2-glycoprotein I in antiphospholipid syndrome: increased reactivity of anti-beta2-glycoprotein I autoantibodies to the valine247 beta2-glycoprotein I variant. Yasuda, S., Atsumi, T., Matsuura, E., Kaihara, K., Yamamoto, D., Ichikawa, K., Koike, T. Arthritis Rheum. (2005)
- An Endogenous Inhibitor of Angiogenesis derived from a Transitional Cell Carcinoma: Clipped beta2-Glycoprotein-I. Beecken, W.D., Engl, T., Ringel, E.M., Camphausen, K., Michaelis, M., Jonas, D., Folkman, J., Shing, Y., Blaheta, R.A. Ann. Surg. Oncol. (2006)
- Serum anti-beta2-glycoprotein-I and anticardiolipin antibodies during thrombosis in systemic lupus erythematosus patients. Gómez-Pacheco, L., Villa, A.R., Drenkard, C., Cabiedes, J., Cabral, A.R., Alarcón-Segovia, D. Am. J. Med. (1999)
- beta 2 glycoprotein-I inhibits factor XII activation on triglyceride rich lipoproteins: the effect of antibodies from plasma of patients with antiphospholipid syndrome. McNally, T., Mackie, I.J., Isenberg, D.A., Machin, S.J. Thromb. Haemost. (1996)
- Antibodies to beta 2-glycoprotein-I: urea resistance, binding specificity, and association with thrombosis. Vlachoyiannopoulos, P.G., Petrovas, C., Tektonidou, M., Krilis, S., Moutsopoulos, H.M. J. Clin. Immunol. (1998)
- Molecular basis of the apolipoprotein H (beta 2-glycoprotein I) protein polymorphism. Sanghera, D.K., Kristensen, T., Hamman, R.F., Kamboh, M.I. Hum. Genet. (1997)
- Human beta 2-glycoprotein I: molecular analysis of DNA and amino acid polymorphism. Steinkasserer, A., Dörner, C., Würzner, R., Sim, R.B. Hum. Genet. (1993)
- Apolipoprotein E and H polymorphisms in Mongolian Buryat: allele frequencies and relationship with plasma lipid levels. Tsunoda, K., Harihara, S., Dashnyam, B., Semjidmaa, D., Yamaguchi, Y., Tanabe, Y., Sakai, N., Sato, A., Sato, K. Hum. Biol. (2002)
- Assignment of apolipoprotein H (APOH: beta-2-glycoprotein I) to human chromosome 17q23----qter; determination of the major expression site. Steinkasserer, A., Cockburn, D.J., Black, D.M., Boyd, Y., Solomon, E., Sim, R.B. Cytogenet. Cell Genet. (1992)
- Apolipoprotein H genetic variability in the population of Krk Island, Croatia. Vitale, K., Trbojević-Cepe, M., Smolej-Narancić, N. Hum. Biol. (2002)
- A hydrophobic sequence at position 313-316 (Leu-Ala-Phe-Trp) in the fifth domain of apolipoprotein H (beta2-glycoprotein I) is crucial for cardiolipin binding. Mehdi, H., Naqvi, A., Kamboh, M.I. Eur. J. Biochem. (2000)
- Genetic association of five apolipoprotein polymorphisms with serum lipoprotein-lipid levels in African blacks. Kamboh, M.I., Bunker, C.H., Aston, C.E., Nestlerode, C.S., McAllister, A.E., Ukoli, F.A. Genet. Epidemiol. (1999)
- Genetic variation in the apolipoprotein H (beta2-glycoprotein I) gene affects plasma apolipoprotein H concentrations. Mehdi, H., Aston, C.E., Sanghera, D.K., Hamman, R.F., Kamboh, M.I. Hum. Genet. (1999)
- Apolipoprotein H (beta-2-glycoprotein I) polymorphism in Asians. Saha, N., Kamboh, M.I., Kelly, L.J., Ferrell, R.E., Tay, J.S. Hum. Biol. (1992)
- Solution structure of human and bovine beta(2)-glycoprotein I revealed by small-angle X-ray scattering. Hammel, M., Kriechbaum, M., Gries, A., Kostner, G.M., Laggner, P., Prassl, R. J. Mol. Biol. (2002)
- The binding site in {beta}2-glycoprotein I for ApoER2' on platelets is located in domain V. van Lummel, M., Pennings, M.T., Derksen, R.H., Urbanus, R.T., Lutters, B.C., Kaldenhoven, N., de Groot, P.G. J. Biol. Chem. (2005)
- High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. Ma, K., Simantov, R., Zhang, J.C., Silverstein, R., Hajjar, K.A., McCrae, K.R. J. Biol. Chem. (2000)
- The role of beta2-glycoprotein I (beta(2)GPI) in the activation of plasminogen. López-Lira, F., Rosales-León, L., Martínez, V.M., Ruiz Ordaz, B.H. Biochim. Biophys. Acta (2006)
- Pathogenesis of antiphospholipid antibodies: impairment of fibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway. Yasuda, S., Bohgaki, M., Atsumi, T., Koike, T. Immunobiology (2005)
- Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Hansen, D.V., Loktev, A.V., Ban, K.H., Jackson, P.K. Mol. Biol. Cell (2004)
- Genetic studies of human apolipoproteins. XVI. APOE polymorphism and cholesterol levels in the Mayans of the Yucatan Peninsula, Mexico. Kamboh, M.I., Weiss, K.M., Ferrell, R.E. Clin. Genet. (1991)
- Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins. Wang, J.W., Howson, J., Haller, E., Kerr, W.G. J. Immunol. (2001)
- Genetic polymorphisms of apolipoproteins A-IV, E and H in Koreans. Kim, H.S., Kamboh, M.I. Hum. Hered. (1998)
- Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). McNeil, H.P., Simpson, R.J., Chesterman, C.N., Krilis, S.A. Proc. Natl. Acad. Sci. U.S.A. (1990)