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Chemical Compound Review

18-HYDROXYCORTICOSTERONE     (8S,9R,10R,11S,13R,14S,17S)- 11-hydroxy-17...

Synonyms: SureCN142427, CHEBI:16485, HMDB00319, AC1L1WVV, KB-64820, ...
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Disease relevance of 18-HYDROXYCORTICOSTERONE


High impact information on 18-HYDROXYCORTICOSTERONE

  • Evaluation of 33 other family members disclosed the biochemical disorder in six other subjects who were affected in an autosomal-recessive pattern with variably severe clinical manifestations and abnormal ratios of 18-hydroxycorticosterone (or its metabolites) to aldosterone [6].
  • When these mutations were individually introduced into CYP11B2 cDNA and expressed in cultured cells, R181W reduced 18-hydroxylase and abolished 18-oxidase activities but left 11 beta-hydroxylase activity intact, whereas V386A caused a small but consistent reduction in the production of 18-hydroxycorticosterone [7].
  • METHODS: Hypertensive patients (N = 3900) referred to our unit were screened for PA by measuring renin activity, urinary aldosterone-18-glucuronide, tetrahydroaldosterone, and 18-hydroxycorticosterone (18-OH-B) [8].
  • He had elevated PRA with low serum and urinary levels of aldosterone and its metabolites and normal or slightly elevated levels of 18-hydroxycorticosterone [9].
  • The evolutionary drive for a hormone specifically designed for hydromineral regulation led to zonation for the conversion of 18-hydroxycorticosterone into aldosterone through the catalytic action of a synthase in the secluded compartment of the adrenal zona glomerulosa [10].

Chemical compound and disease context of 18-HYDROXYCORTICOSTERONE


Biological context of 18-HYDROXYCORTICOSTERONE


Anatomical context of 18-HYDROXYCORTICOSTERONE


Associations of 18-HYDROXYCORTICOSTERONE with other chemical compounds




Analytical, diagnostic and therapeutic context of 18-HYDROXYCORTICOSTERONE


  1. Use of computed tomography in diagnosing the cause of primary aldosteronism. White, E.A., Schambelan, M., Rost, C.R., Biglieri, E.G., Moss, A.A., Korobkin, M. N. Engl. J. Med. (1980) [Pubmed]
  2. Responsiveness of plasma 18-hydroxycorticosterone and aldosterone to angiotensin II or corticotropin in nonazotemic diabetes mellitus. Beretta-Piccoli, C., Weidmann, P., Fraser, R. Diabetes (1983) [Pubmed]
  3. Distinctive plasma aldosterone, 18-hydroxycorticosterone, and 18-hydroxydeoxycorticosterone profile in the 21-, 17 alpha-, and 11 beta-hydroxylase deficiency types of congenital adrenal hyperplasia. Kater, C.E., Biglieri, E.G. Am. J. Med. (1983) [Pubmed]
  4. Response of aldosterone and 18-hydroxycorticosterone to angiotensin II in normal subjects and patients with essential hypertension, Conn's syndrome, and nontumorous hyperaldosteronism. Fraser, R., Beretta-Piccoli, C., Brown, J.J., Cumming, A.M., Lever, A.F., Mason, P.A., Morton, J.J., Robertson, J.I. Hypertension (1981) [Pubmed]
  5. Prohormones in adrenal venous effluent in patients with primary hyperaldosteronism. Rao, A., Melby, J.C., Wilson, T.E. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  6. Inborn error in the terminal step of aldosterone biosynthesis. Corticosterone methyl oxidase tpe II deficiency in a North American pedigree. Veldhuis, J.D., Kulin, H.E., Santen, R.J., Wilson, T.E., Melby, J.C. N. Engl. J. Med. (1980) [Pubmed]
  7. Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. Pascoe, L., Curnow, K.M., Slutsker, L., Rösler, A., White, P.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Prevalence of adrenal and extra-adrenal Conn syndrome in hypertensive patients. Abdelhamid, S., Müller-Lobeck, H., Pahl, S., Remberger, K., Bönhof, J.A., Walb, D., Röckel, A. Arch. Intern. Med. (1996) [Pubmed]
  9. Type 1 aldosterone synthase deficiency presenting in a middle-aged man. Kayes-Wandover, K.M., Schindler, R.E., Taylor, H.C., White, P.C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  10. General overview of mineralocorticoid hormone action. Agarwal, M.K., Mirshahi, M. Pharmacol. Ther. (1999) [Pubmed]
  11. Effects of bromocriptine on the circadian rhythm of 18-hydroxycorticosterone and cortisol secretion in essential hypertensives. Sowers, J.R., Tuck, M.L., Beck, F.W., Stern, N. J. Hypertens. (1983) [Pubmed]
  12. Adrenal adenoma with excess secretion of corticosterone and 18-hydroxycorticosterone. Morioka, M., Sen, Y., Inoue, K., Fujita, Y. J. Urol. (1990) [Pubmed]
  13. Urinary steroid profile in adrenocortical tumors. Kikuchi, E., Yanaihara, H., Nakashima, J., Homma, K., Ohigashi, T., Asakura, H., Tachibana, M., Shibata, H., Saruta, T., Murai, M. Biomed. Pharmacother. (2000) [Pubmed]
  14. Influence of sodium homeostasis and circadian rhythm on dopaminergic modulation of 18-hydroxycorticosterone secretion in man. Sowers, J.R., Stern, N. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  15. Urinary free 18-hydroxycorticosterone, plasma aldosterone, and urinary aldosterone metabolites in normal pregnancy. Bauknecht, H., Vecsei, P., Endres, H., Hettenbach, A. Am. J. Obstet. Gynecol. (1982) [Pubmed]
  16. In vitro steroid biosynthesis by the adrenal gland of the female Lacerta vivipara Jacquin: the metabolism of exogenous precursors. Dauphin-Villemant, C., Xavier, F. Gen. Comp. Endocrinol. (1985) [Pubmed]
  17. Stimulation of oxygen consumption at the cytochrome A3 level inhibits aldosterone biosynthesis from 18-hydroxycorticosterone. Aupetit, B., Emeric, N., Toury, R., Racadot, O., Racadot, J., Vonarx, V., Legrand, J.C. Biochim. Biophys. Acta (1986) [Pubmed]
  18. Hypersecretion of a new corticosteroid, 18-hydroxycortisol in two types of adrenocortical hypertension. Ulick, S., Chu, M.D. Clinical and experimental hypertension. Part A, Theory and practice. (1982) [Pubmed]
  19. Zona fasciculata origin of 18-hydroxycorticosterone in the chronically suppressed zona glomerulosa. Kater, C.E., Biglieri, E.G. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  20. Effect of chronic adrenocorticotropin stimulation on the excretion of 18-hydroxycortisol and 18-oxocortisol. Gomez-Sanchez, C.E., Clore, J.N., Estep, H.L., Watlington, C.O. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  21. Distribution of 18-hydroxycorticosterone between red blood cells and plasma. Zager, P.G., Frey, H.J., Spalding, C.T., Wengs, W.J., Brittenham, M.C. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  22. Suramin: an inhibitor of the final steps of the mineralocorticoid pathway? Zenatti, M., Blanchouin-Emeric, N., Koplewicz, S., Defaye, G., Aupetit-Faisant, B. J. Steroid Biochem. Mol. Biol. (1994) [Pubmed]
  23. The biosynthesis of aldosterone. Vinson, G.P., Laird, S.M., Whitehouse, B.J., Teja, R., Hinson, J.P. J. Steroid Biochem. Mol. Biol. (1991) [Pubmed]
  24. Human fetal adrenal definitive and fetal zone metabolism of pregnenolone and corticosterone: alternate biosynthetic pathways and absence of detectable aldosterone synthesis. Nelson, H.P., Kuhn, R.W., Deyman, M.E., Jaffe, R.B. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  25. 17 alpha-hydroxylase deficiency: mineralocorticoid hormone profiles in an affected family. D'Armiento, M., Reda, G., Kater, C., Shackleton, C.H., Biglieri, E.G. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  26. Effect of domperidone, an extracerebral inhibitor of dopamine receptors, on thyrotropin, prolactin, renin, aldosterone, and 18-hydroxycorticosterone secretion in man. Sowers, J.R., Sharp, B., McCallum, R.W. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  27. Charged chelate-capillary electrophoresis of endogenous corticosteroids. Palmer, J., Atkinson, S., Yoshida, W.Y., Stalcup, A.M., Landers, J.P. Electrophoresis (1998) [Pubmed]
  28. Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells. Cao, P.R., Bernhardt, R. Eur. J. Biochem. (1999) [Pubmed]
  29. Endothelin-1 stimulates aldosterone synthesis in Conn's adenomas via both A and B receptors coupled with the protein kinase C- and cyclooxygenase-dependent signaling pathways. Rossi, G.P., Andreis, P.G., Neri, G., Tortorella, C., Pelizzo, M.R., Sacchetto, A., Nussdorfer, G.G. J. Investig. Med. (2000) [Pubmed]
  30. New studies of the 11 beta-hydroxylase and 18-hydroxylase enzymes in the hypertensive form of congenital adrenal hyperplasia. Levine, L.S., Rauh, W., Gottesdiener, K., Chow, D., Gunczler, P., Rapaport, R., Pang, S., Schneider, B., New, M.I. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  31. Suppression of adrenal mineralocorticoid production in prehypertensive young adult men. Guthrie, G.P., Kotchen, T.A., Kotchen, J.M. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  32. Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adrenal adenoma. Phillips, J.L., Walther, M.M., Pezzullo, J.C., Rayford, W., Choyke, P.L., Berman, A.A., Linehan, W.M., Doppman, J.L., Gill Jr, J.R. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  33. Role of the renin-angiotensin system in the regulation of late steps in aldosterone biosynthesis by sodium intake of potassium-deficient rats. Müller, J., Hofstetter, L., Schwendener-Canlas, P., Brunner, D.B., Lund, E.G. Endocrinology (1984) [Pubmed]
  34. Plasma concentrations of 18-hydroxycorticosterone and aldosterone in continuous ambulatory peritoneal dialysis and hemodialysis patients. Zager, P.G., Frey, H.J., Gerdes, B.G. Am. J. Kidney Dis. (1983) [Pubmed]
  35. Application of reversed-phase high-performance liquid chromatography for radioimmunoassay of plasma 18-hydroxycorticosterone. Imaizumi, N., Morimoto, S., Kigoshi, T., Uchida, K., Hosojima, H., Yamamoto, I. J. Chromatogr. (1984) [Pubmed]
  36. Enzyme immunoassay for serum 18-hydroxycorticosterone and its clinical application. Watanabe, F., Ryota, T., Kobayashi, Y. Steroids (1984) [Pubmed]
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