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Disease relevance of Trypanosomatina


High impact information on Trypanosomatina


Biological context of Trypanosomatina

  • Small nucleolar RNA clusters in trypanosomatid Leptomonas collosoma. Genome organization, expression studies, and the potential role of sequences present upstream from the first repeated cluster [6].
  • RNA editing associated with the generation of two distinct conformations of the trypanosomatid Leptomonas collosoma 7SL RNA [7].
  • Characterization of RNA transcripts from the alpha tubulin gene cluster of Leptomonas seymouri [8].
  • Although obtusifoliol specificity is typical for plant isoforms of CYP51, the set of sterol biosynthetic enzymes in the protozoan genomes together with available information about sterol composition of kinetoplastid cells suggest that the substrate preference of TBCYP51 may reflect a novel sterol biosynthetic pathway in Trypanosomatidae [9].
  • Previously we have shown that a single copy of a MX gene can be expressed continuously from a stable episome transfected into the monogenetic trypanosomatid Leptomonas seymouri [10].

Anatomical context of Trypanosomatina


Associations of Trypanosomatina with chemical compounds


Gene context of Trypanosomatina

  • Tryparedoxin peroxidase (TXNPx), recently identified as the hydroperoxide-detoxifying enzyme of trypanosomatidae [Nogoceke, E., Gommel, D. U., Kiess, M., Kalisz, H. M. & Flohé, L. (1997) Biol. Chem. 378, 827-836], is a member of the peroxiredoxin family and is characterized by two VCP motifs [20].
  • In this study, we characterized four snoRNA clusters in Leptomonas collosoma [6].
  • Moreover, only genes related to the glycosomal GAPDH genes of Trypanosomatidae could be detected [21].
  • Magnesium-dependent ecto-ATP diphosphohydrolase activity in Herpetomonas muscarum muscarum [22].
  • Using conventional chromatography, we discovered a small RNA molecule of 85 nucleotides co-migrating with the Leptomonas collosoma 7SL RNA [23].

Analytical, diagnostic and therapeutic context of Trypanosomatina


  1. Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli. Pérez, J., Gallego, C., Bernier-Villamor, V., Camacho, A., González-Pacanowska, D., Ruiz-Pérez, L.M. Nucleic Acids Res. (1999) [Pubmed]
  2. Receptor for immunoglobulin Fc on pathogenic but not on nonpathogenic protozoa of the Trypanosomatidae. De Miranda-Santos, I.K., Campos-Neto, A. J. Exp. Med. (1981) [Pubmed]
  3. Spliced leader RNA of trypanosomes: in vivo mutational analysis reveals extensive and distinct requirements for trans splicing and cap4 formation. Lücke, S., Xu, G.L., Palfi, Z., Cross, M., Bellofatto, V., Bindereif, A. EMBO J. (1996) [Pubmed]
  4. Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA transferase. Van Hellemond, J.J., Opperdoes, F.R., Tielens, A.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. The boundaries of partially edited transcripts are not conserved in kinetoplastids: implications for the guide RNA model of editing. Landweber, L.F., Fiks, A.G., Gilbert, W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Small nucleolar RNA clusters in trypanosomatid Leptomonas collosoma. Genome organization, expression studies, and the potential role of sequences present upstream from the first repeated cluster. Liang, X.H., Ochaion, A., Xu, Y.X., Liu, Q., Michaeli, S. J. Biol. Chem. (2004) [Pubmed]
  7. RNA editing associated with the generation of two distinct conformations of the trypanosomatid Leptomonas collosoma 7SL RNA. Ben-Shlomo, H., Levitan, A., Shay, N.E., Goncharov, I., Michaeli, S. J. Biol. Chem. (1999) [Pubmed]
  8. Characterization of RNA transcripts from the alpha tubulin gene cluster of Leptomonas seymouri. Bellofatto, V., Cross, G.A. Nucleic Acids Res. (1988) [Pubmed]
  9. CYP51 from Trypanosoma brucei is obtusifoliol-specific. Lepesheva, G.I., Nes, W.D., Zhou, W., Hill, G.C., Waterman, M.R. Biochemistry (2004) [Pubmed]
  10. Essential components of the mini-exon gene promoter in the trypanosomatid Leptomonas seymouri. Hartree, D., Bellofatto, V. Mol. Biochem. Parasitol. (1995) [Pubmed]
  11. Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase. Baumgart, E., Vanhooren, J.C., Fransen, M., Van Leuven, F., Fahimi, H.D., Van Veldhoven, P.P., Mannaerts, G.P. Biochem. J. (1996) [Pubmed]
  12. A proton pumping pyrophosphatase in acidocalcisomes of Herpetomonas sp. Soares Medeiros, L.C., Moreira, B.L., Miranda, K., de Souza, W., Plattner, H., Hentschel, J., Barrabin, H. Mol. Biochem. Parasitol. (2005) [Pubmed]
  13. The cyclopropane fatty acid of trypanosomatids. Fish, W.R., Holz, G.G., Beach, D.H., Owen, E., Anekwe, G.E. Mol. Biochem. Parasitol. (1981) [Pubmed]
  14. Influence of 2-deoxy-D-glucose on the localization of concanavalin A receptors on the cell membrane of Herpetomonas sp. De Souza, W., Bunn, M.M., Angluster, J. Cytobiologie. (1976) [Pubmed]
  15. Phagocytosis of Herpetomonas samuelpessoai by mouse peritoneal macrophages: effect of lidocaine, concanavalin A and carbohydrates. Oda, L.M., Alviano, C.S., Angluster, J., De Souza, W. J. Submicrosc. Cytol. (1982) [Pubmed]
  16. Mitochondrial localization of the mevalonate pathway enzyme 3-Hydroxy-3-methyl-glutaryl-CoA reductase in the Trypanosomatidae. Peña-Diaz, J., Montalvetti, A., Flores, C.L., Constán, A., Hurtado-Guerrero, R., De Souza, W., Gancedo, C., Ruiz-Perez, L.M., Gonzalez-Pacanowska, D. Mol. Biol. Cell (2004) [Pubmed]
  17. Novel (rhamnosyl and ribosyl) and uncommon (xylosyl) monosaccharide residues are present in asparagine-linked oligosaccharides of the trypanosomatid Blastocrithidia culicis. Merello, S., Xavier, M.T., Parodi, A.J. J. Biol. Chem. (1994) [Pubmed]
  18. Structural characterization of a novel class of glycophosphosphingolipids from the protozoan Leptomonas samueli. Previato, J.O., Mendonça-Previato, L., Jones, C., Wait, R., Fournet, B. J. Biol. Chem. (1992) [Pubmed]
  19. Leishmania major elongation factor 1B complex has trypanothione S-transferase and peroxidase activity. Vickers, T.J., Wyllie, S., Fairlamb, A.H. J. Biol. Chem. (2004) [Pubmed]
  20. Activation of active-site cysteine residues in the peroxiredoxin-type tryparedoxin peroxidase of Crithidia fasciculata. Montemartini, M., Kalisz, H.M., Hecht, H.J., Steinert, P., Flohé, L. Eur. J. Biochem. (1999) [Pubmed]
  21. Molecular analysis of glyceraldehyde-3-phosphate dehydrogenase in Trypanoplasma borelli: an evolutionary scenario of subcellular compartmentation in kinetoplastida. Wiemer, E.A., Hannaert, V., van den IJssel, P.R., Van Roy, J., Opperdoes, F.R., Michels, P.A. J. Mol. Evol. (1995) [Pubmed]
  22. Magnesium-dependent ecto-ATP diphosphohydrolase activity in Herpetomonas muscarum muscarum. Alves-Ferreira, M., Dutra, P.M., Lopes, A.H., Ferreira-Pereira, A., Scofano, H.M., Meyer-Fernandes, J.R. Curr. Microbiol. (2003) [Pubmed]
  23. The trypanosomatid signal recognition particle consists of two RNA molecules, a 7SL RNA homologue and a novel tRNA-like molecule. Liu, L., Ben-Shlomo, H., Xu, Y.X., Stern, M.Z., Goncharov, I., Zhang, Y., Michaeli, S. J. Biol. Chem. (2003) [Pubmed]
  24. Polyamines in trypanosomatids. Bacchi, C.J., Lipschik, G.Y., Nathan, H.C. J. Bacteriol. (1977) [Pubmed]
  25. Changes of sialomolecules during the dimethylsulfoxide-induced differentiation of Herpetomonas samuelpessoai. dos Santos, A.L., Rodrigues, M.L., Alviano, C.S., de Araujo Soares, R.M. Parasitol. Res. (2002) [Pubmed]
  26. Characterization of proteinases in Herpetomonas anglusteri and Herpetomonas roitmani. Souza dos Santos, A.L., Ferreira, A., Franco, V.A., Alviano, C.S., de Araújo Soares, R.M. Curr. Microbiol. (1999) [Pubmed]
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