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Chemical Compound Review

AG-E-87942     pyrrolidine-2-carbothioic acid

Synonyms: AC1L3OEH, CTK0J2530, AR-1E5355, AC1Q68QO, 2-Pyrrolidinecarbothioic acid, ...
 
 
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Disease relevance of L-Thioproline

 

High impact information on L-Thioproline

 

Chemical compound and disease context of L-Thioproline

 

Biological context of L-Thioproline

 

Anatomical context of L-Thioproline

 

Associations of L-Thioproline with other chemical compounds

 

Gene context of L-Thioproline

  • In these slow mice, which are a model of premature immunosenescence, the immune functions were improved after the ingestion of the thiolic antioxidant thioproline in the diet [21].
  • Thioproline was unable to effect reproducibly morphologic changes characteristic of the reversed transformed state of HeLa, WI-38VA13, C1300 neuroblastoma, and CHO-K1 cell lines [22].
 

Analytical, diagnostic and therapeutic context of L-Thioproline

References

  1. Thioproline toxicity. Nasca, S., Galichet, V., Jardillier, J.C., Garbe, E., Coninx, P. Lancet (1981) [Pubmed]
  2. Thioproline in squamous cell cancer. Sappino, A.P., Smith, I.E. Lancet (1980) [Pubmed]
  3. Thioproline inhibits development of esophageal adenocarcinoma induced by gastroduodenal reflux in rats. Kumagai, H., Mukaisho, K., Sugihara, H., Miwa, K., Yamamoto, G., Hattori, T. Carcinogenesis (2004) [Pubmed]
  4. Thioproline prevents carcinogenesis in the remnant stomach induced by duodenal reflux. Suo, M., Mukaisho, K., Shimomura, A., Sugihara, H., Hattori, T. Cancer Lett. (2006) [Pubmed]
  5. Lack of reverse transformation after treatment of A 549 human alveolar carcinoma cells with thioproline. Rigaud, O., Coppey, J., Magdelenat, H. Cancer Lett. (1983) [Pubmed]
  6. Treatment of cancer by an inducer of reverse transformation. Brugarolas, A., Gosalvez, M. Lancet (1980) [Pubmed]
  7. Marked increase in the urinary level of N-nitrosothioproline after ingestion of cod with vegetables. Tsuda, M., Frank, N., Sato, S., Sugimura, T. Cancer Res. (1988) [Pubmed]
  8. Effect of L-thioproline on the progression and events of the cell cycle of HeLa cells. García Cañero, R., López-Alarcón, L., Veloso, J.J., del Carmen Guijarro, M. Int. J. Cancer (1988) [Pubmed]
  9. Inhibition of angiogenesis through modulation of collagen metabolism. Ingber, D., Folkman, J. Lab. Invest. (1988) [Pubmed]
  10. Improvement of murine immune functions in vitro by thioproline. Correa, R., Del Río, M., De La Fuente, M. Immunopharmacology (1999) [Pubmed]
  11. The influence of thyroid hormones on colony growth of peripheral CFU-GM from normal and leukemic subjects. Notario, A., Torriani, A., Bravi, M., Broglia, M., Borghi, G., Guerra, G. Tumori. (1988) [Pubmed]
  12. Functional analysis of the CPS I upstream sequences with a cat assay. Niu, B., Wang, Z., Yu, Y., Wang, M., Zeng, S., Li, S. Chin. Med. Sci. J. (1991) [Pubmed]
  13. Toxicity of paracetamol in human hepatocytes. Comparison of the protective effects of sulfhydryl compounds acting as glutathione precursors. Larrauri, A., Fabra, R., Gómez-Lechón, M.J., Trullenque, R., Castell, J.V. Molecular toxicology. (1987) [Pubmed]
  14. Effect of a diet supplemented with thioproline on murine macrophage function in a model of premature ageing. Correa, R., Blanco, B., Del Río, M., Víctor, V., Guayerbas, N., Medina, S., De la Fuente, M. Biofactors (1999) [Pubmed]
  15. Effect of thiazolidine-4-carboxylic acid (Thioproline) on sister chromatid exchanges in CHO cells and human lymphocytes, and on the kinetics of human lymphocytes in vitro. Teyssier, J.R. Cancer Genet. Cytogenet. (1982) [Pubmed]
  16. Dietary thioproline decreases spontaneous food intake and increases survival and neurological function in mice. Navarro, A., S??nchez-Pino, M.J., G??mez, C., B??ndez, M.J., Cadenas, E., Boveris, A. Antioxid. Redox Signal. (2007) [Pubmed]
  17. Enhancement of leukocyte functions in aged mice supplemented with the antioxidant thioproline. De la Fuente, M., Ferrández, M.D., Del Rio, M., Sol Burgos, M., Miquel, J. Mech. Ageing Dev. (1998) [Pubmed]
  18. Time-lapse microcinematography of the effect of thiazolidine carboxylic acid (thioproline) upon tissue cultures. Alvarez-Rodríguez, Y., Ruano, A., Alvarez-Noves, J., Valladares, Y. Revista española de oncología. (1985) [Pubmed]
  19. Mutagenicity and cytotoxicity of N-nitrosothiazolidine-4-carboxylic acid. Lin, I.N., Gruenwedel, D.W. Food additives and contaminants. (1990) [Pubmed]
  20. The inhibitory effect of thioproline on carcinogenesis induced by N-benzylmethylamine and nitrite. Tahira, T., Ohgaki, H., Wakabayashi, K., Nagao, M., Sugimura, T. Food Chem. Toxicol. (1988) [Pubmed]
  21. Effects of N-acetylcysteine on macrophage and lymphocyte functions in a mouse model of premature ageing. Puerto, M., Guayerbas, N., Víctor, V., De la Fuente, M. Pharmacol. Biochem. Behav. (2002) [Pubmed]
  22. Pharmacologic and toxicologic evaluation of thioproline: a proposed nontoxic inducer of reverse transformation. Newman, R.A., Hacker, M.P., McCormack, J.J., Krakoff, I.H. Cancer treatment reports. (1980) [Pubmed]
  23. Determination of thioproline in plasma using high performance liquid chromatography. Lankelma, J., Penders, P.G., Leyva, A., Pinedo, H.M. Cancer Lett. (1981) [Pubmed]
 
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