Disease relevance of Dota acid

• This experimental study was designed to evaluate the sensitivity of MRI in the detection of acute myocardial infarction, determine the utility of fast gradient-echo (GE) imaging and study possible improvements in diagnostic efficacy using a paramagnetic contrast agent (gadolinium-DOTA) [1].
• Gadodiamide injection has been shown to have a remarkably low acute lethal toxicity, superior to that of gadopentetate dimeglumine injection (Magnevist, Berlex Laboratories, Wayne, NJ, and Schering AG, Berlin, Germany) or gadoterate meglumine (Dotarem, Laboratoire Guerbet, Aulnay-Sous-Bois, France) [2].
• Gadolinium-DOTA was administered intravenously in a dosage of 0.1 mmol/kg body weight [3].
• CONCLUSION: Gadoterate-enhanced digital subtraction angiography is an effective and safe method to assess causes of malfunction of hemodialysis fistulas [4].
• Stability and sterility of meglumine gadoterate injection repackaged in plastic syringes [5].

High impact information on Dota acid

• We propose a non-invasive distension method for magnetic-resonance imaging (MRI) in which ispaghula, dissolved in an aqueous solution with meglumine gadoterate taken orally over 4 h forms a viscous hydrogel within the intestinal lumen [6].
• Gadolinium-DOTA (Dotarem) was used as a contrast agent to detect vessel permeability and contrast agent extravasation, whereas intravascular iron oxide nanoparticles (Endorem) were used to detect partial tumor blood volume [7].
• MATERIALS AND METHODS: LLC-PK1 cells were incubated with iomeprol, gadopentetate dimeglumine, gadobenate dimeglumine, gadoterate meglumine, gadodiamide, and corresponding mannitol solutions for 24 hours at 37 degrees C in two experimental settings: measurements with equally attenuating solutions and measurements with equimolar solutions [8].
• Scarred myocardium was recognized as a bright region on gadoterate meglumine-enhanced images [9].
• PURPOSE: To compare the diagnostic accuracy of gadobenate dimeglumine (Gd-BOPTA)-enhanced versus gadoterate meglumine (Gd-DOTA)-enhanced magnetic resonance (MR) angiography in patients with peripheral arterial occlusive disease (PAOD) [10].

Chemical compound and disease context of Dota acid

• All patients underwent evaluation with intracavernous pharmacotesting, color Doppler sonography (CDS), digital subtraction angiography (DSA) and pelvic MR-angiography with gadolinium diethylene-triaminepentaacetic acid (Gd-Dota) 0.2-0.3 mmol/kg body weight [11].

Biological context of Dota acid

• Influence of contrast media (iopromide, ioxaglate, gadolinium-DOTA) on blood viscosity, erythrocyte morphology and platelet function [12].

Anatomical context of Dota acid

• CONCLUSION: As a widely tested positive-enhancing T1 contrast agent with favorable safety features, gadoterate meglumine allows the depiction of three to four successive lymph node groups early after subcutaneous injection [13].
• Evaluation of renal arteries with use of gadoterate meglumine-, CO(2)-, and iodixanol-enhanced DSA measurements versus histomorphometry in renal artery restenosis in rabbits [14].
• Gadodiamide injection as a contrast medium for MRI of the central nervous system: a comparison with gadolinium-DOTA [15].

Associations of Dota acid with other chemical compounds

• MR arthrography was performed with 10-15 ml of a 250 mmol/l gadoterate meglumine (Gd-DOTA) solution injected under fluoroscopic guidance, and transaxial, oblique coronal and sagittal MR sequences were obtained [16].

Gene context of Dota acid

• MR imaging of the knee in acute rheumatoid arthritis: synovial uptake of gadolinium-DOTA [17].

Analytical, diagnostic and therapeutic context of Dota acid

• Functional evaluation of normal and ischemic kidney by means of gadolinium-DOTA enhanced TurboFLASH MR imaging: a preliminary comparison with 99Tc-MAG3 dynamic scintigraphy [18].
• MR arterial portography with gadolinium-DOTA: analysis of nontumoral perfusion abnormalities [19].
• Indeed, in adults (n = 3), an intravenous injection of gadolinium-DOTA induced in a first step a massive and rapid drop in kidney signal intensity followed, in a second step, by a drop in bladder signal intensity [20].
• Meglumine gadoterate: a new safe radiocontrast medium for endoscopic retrograde cholangiopancreatography [21]?
• PROCEDURE: Magnetic resonance imaging (MRI) was performed with and without intra-articular injection of a solution of 2 mmol of gadolinium-DOTA/L [22].

References