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Chemical Compound Review

Levoleucovorin     (2S)-2-[[4-[[(6S)-2-amino-5- methanoyl-4...

Synonyms: Levofolene, levo-Folinic, L-Folinic acid, AG-G-64159, CHEBI:63606, ...
 
 
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Disease relevance of folinic acid

 

High impact information on folinic acid

  • We also determined the plasma pharmacokinetics of folates after intravenous (IV) injection of (6S)-folinic acid at the dose used in this study [6].
  • They may have implications for the identification of patients resistant to FU chemotherapy and for a better understanding and management of FU modulation by folinic acid (FA) [7].
  • We investigated the biological activities of the natural and unnatural diastereoisomers of 5-formyltetrahydrofolate [(6S)- and (6R)-5-HCO-H4PteGlu, respectively, both 99.99% pure], using a human ileocecal carcinoma cell line (HCT-8) [8].
  • [6RS]Leucovorin (5-formyltetrahydrofolate; 5-CHO-H4PteGlu) administered in different regimens in combination with 5-fluorouracil (FUra) has increased the response rates to FUra in patients with colon adenocarcinoma [9].
  • We used our model of HD-MTX neurotoxicity in the rat to determine if leucovorin (5-formyltetrahydrofolate) reduces this neurotoxicity, and extended our characterization of this model to identify regional as well as global HD-MTX treatment effects and to investigate HD-MTX-induced alterations in regional brain pH [10].
 

Chemical compound and disease context of folinic acid

 

Biological context of folinic acid

 

Anatomical context of folinic acid

 

Associations of folinic acid with other chemical compounds

 

Gene context of folinic acid

 

Analytical, diagnostic and therapeutic context of folinic acid

  • HD-MTX (8 g/m2) therapy with 5-formyltetrahydrofolate "rescue" (stage III) was usually begun about seven weeks after start of chemotherapy, and the patients were followed for two to eight courses separated by three to eight weeks [34].
  • CONCLUSIONS: Relative to high-dose FA, high-dose oral L-folinic acid-based supplementation does not afford improved tHcy-lowering efficacy in hemodialysis patients [12].
  • We present a rapid, sensitive, and automated HPLC method with direct resolution of l-folinic acid (l-FA), d-folinic acid (d-FA), and 5-methyltetrahydrofolate (5MTHF) from plasma samples [35].
  • The thermodynamic parameters for the binding of 5-formyltetrahydrofolate (5-CHO-H4PteGlun) and its polyglutamate forms to rabbit liver cytosolic serine hydroxymethyltransferase (SHMT) were determined by a combination of isothermal titration calorimetry and spectrophotometry [36].
  • Adjuvant chemotherapy (5-FU + l-folinic acid) was delivered to 26 patients in the FUMIR-T4 protocol group [37].

References

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  11. Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. Zhao, R., Zhang, S., Hanscom, M., Chattopadhyay, S., Goldman, I.D. Clin. Cancer Res. (2005) [Pubmed]
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  26. Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation. Anguera, M.C., Suh, J.R., Ghandour, H., Nasrallah, I.M., Selhub, J., Stover, P.J. J. Biol. Chem. (2003) [Pubmed]
  27. Identification of protein-arginine N-methyltransferase as 10-formyltetrahydrofolate dehydrogenase. Kim, S., Park, G.H., Joo, W.A., Paik, W.K., Cook, R.J., Williams, K.R. J. Biol. Chem. (1998) [Pubmed]
  28. Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms. Akbulut, H., Tang, Y., Maynard, J., Zhang, L., Pizzorno, G., Deisseroth, A. Clin. Cancer Res. (2004) [Pubmed]
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  30. Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement. Brigle, K.E., Westin, E.H., Houghton, M.T., Goldman, I.D. J. Biol. Chem. (1991) [Pubmed]
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