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Chemical Compound Review

Amidefrine     N-[3-(1-hydroxy-2- methylamino...

Synonyms: amidephrine, CHEMBL146408, SureCN122479, CHEBI:344414, LS-174423, ...
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Disease relevance of amidephrine

  • 3. The combined administration of amidephrine (3 microg kg(-1) min(-1)) and isoprenaline (0.3 microg kg(-1) min(-1)) evoked a potentiated increase in insulin plasma levels in the face of a weak hyperglycaemia, an established reduction in blood pressure and tachycardia [1].

High impact information on amidephrine


Biological context of amidephrine

  • There was no significant difference between NWR and SHR in the potency of amidephrine in causing a postjunctionally mediated potentiation of the isometric contraction to single pulse field stimulation in prostatic portions but the maximum potentiation was significantly reduced in SHR [4].
  • The alpha-adrenergic effect on lipid mobilization was investigated by comparing the modifications of blood glycerol levels induced by clonidine (alpha 2-agonist) and amidephrine (alpha 1-agonist) alone or in combination with isoprenaline (beta-agonist) [6].
  • Amidephrine did not affect heart rate at the lower dose (1-10 microgram) [7].
  • Because relatively few alpha 1-agonists have been tested to date using the systemic route of exposure, the present study examined the effects of the alpha 1-adrenoceptor agonists amidephrine and SKF-89748 on food and water intake [8].
  • In contrast, competition curves of adrenaline, oxymetazoline, amidephrine and YM-12617 (5-[2-[[2-(o-ethoxy-phenoxy)ethyl]-amino]propyl]-2- methoxybenzenesulfonamide HCl) were best described by a model of two binding sites [9].

Anatomical context of amidephrine


Associations of amidephrine with other chemical compounds


Analytical, diagnostic and therapeutic context of amidephrine


  1. Role of alpha2-adrenoceptors on the hyperglycaemic and insulin secretory effects derived from alpha1- and beta-adrenoceptor stimulation in the rabbit. García-Barrado, M.J., Sancho, C., Palomero, J., Moratinos, J. Journal of autonomic pharmacology. (1998) [Pubmed]
  2. Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine. MacLean, M.R., Thomson, M., Hiley, C.R. Br. J. Pharmacol. (1989) [Pubmed]
  3. Identification of a single alpha 1-adrenoceptor corresponding to the alpha 1A-subtype in rat submaxillary gland. Michel, A.D., Loury, D.N., Whiting, R.L. Br. J. Pharmacol. (1989) [Pubmed]
  4. An investigation of alpha-adrenoceptor responsiveness in the vas deferens of spontaneously hypertensive rats. Docherty, J.R., Warnock, P. Br. J. Pharmacol. (1985) [Pubmed]
  5. Prostaglandin synthesis and renal vasoconstriction elicited by adrenergic stimuli are linked to activation of alpha-1 adrenergic receptors in the isolated rat kidney. Cooper, C.L., Malik, K.U. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  6. In vivo evidence for alpha 2-adrenergic-dependent inhibition of lipid mobilization in the rabbit. Carpene, C., De Pablos, I., Viguera, L., Moratinos, J. Eur. J. Pharmacol. (1984) [Pubmed]
  7. Cardiac alpha-1 adrenoceptors are not involved in heart rate control of the anaesthetized dog. Borgdorff, P., Verlato, G., Cevese, A. Pflugers Arch. (1987) [Pubmed]
  8. Effects on food and water intake of the alpha 1-adrenoceptor agonists amidephrine and SK&F-89748. Morien, A., McMahon, L., Wellman, P.J. Life Sci. (1993) [Pubmed]
  9. Alpha 1-adrenoceptors: the ability of various agonists and antagonists to discriminate between two distinct [3H]prazosin binding sites. Hanft, G., Gross, G., Beckeringh, J.J., Korstanje, C. J. Pharm. Pharmacol. (1989) [Pubmed]
  10. An investigation of presynaptic alpha-adrenoceptor subtypes in the pithed rat heart and in the rat isolated vas deferens. Docherty, J.R. Br. J. Pharmacol. (1984) [Pubmed]
  11. Neuromuscular blocking agents inhibit receptor-mediated increases in the potassium permeability of intestinal smooth muscle. Gater, P.R., Haylett, D.G., Jenkinson, D.H. Br. J. Pharmacol. (1985) [Pubmed]
  12. Blockade by WB 4101 of alpha-adrenoceptors in the rat vas deferens and guinea-pig taenia caeci. Butler, M., Jenkinson, D.H. Eur. J. Pharmacol. (1978) [Pubmed]
  13. Heterogeneity of the interaction between alpha 1- and alpha 2-adrenoceptor agonists with their respective receptors in the vascular system of the pithed rat. Wilffert, B., De Jonge, A., Thoolen, M.J., Timmermans, P.B., Van Zwieten, P.A. Eur. J. Pharmacol. (1984) [Pubmed]
  14. Alpha- and beta-adrenoceptor cross-talk in the regulation of glycogenolysis in dog and guinea-pig liver. Maroto, R., Calvo, S., Sancho, C., Esquerro, E. Archives internationales de pharmacodynamie et de thérapie. (1992) [Pubmed]
  15. Role of alpha 1- and alpha 2-adrenoceptors in catecholamine-induced hyperglycaemia, lipolysis and insulin secretion in conscious fasted rabbits. Moratinos, J., Carpene, C., de Pablos, I., Reverte, M. Br. J. Pharmacol. (1988) [Pubmed]
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