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Chemical Compound Review

ACADESINE     5-amino-1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Acadesina, Arasine, Protara, Acadesinum, Acadra, ...
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Disease relevance of AIC-Riboside


High impact information on AIC-Riboside


Chemical compound and disease context of AIC-Riboside


Biological context of AIC-Riboside


Anatomical context of AIC-Riboside


Associations of AIC-Riboside with other chemical compounds


Gene context of AIC-Riboside

  • Supplementation with AICA riboside lowered the levels of fixN expression in the purF mutants [16].
  • Activation of AMPK by AICA riboside was greatly attenuated by inhibitors of equilibrative nucleoside transport [1].
  • AICA riboside treatment of INS-1 cells, and of isolated rat islets, had both inhibitory and stimulatory effects on insulin secretion [17].
  • In order to exert its effect on viability, AICA riboside must enter the cells and be phosphorylated to the ribotide, since both a nucleoside transport inhibitor, and an inhibitor of adenosine kinase produce an enhancement of the viability of AICA riboside-treated cells [2].
  • Insulinotropic action of AICA riboside. I. Insulin release by isolated islets and the perfused pancreas [18].

Analytical, diagnostic and therapeutic context of AIC-Riboside


  1. AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. Gadalla, A.E., Pearson, T., Currie, A.J., Dale, N., Hawley, S.A., Sheehan, M., Hirst, W., Michel, A.D., Randall, A., Hardie, D.G., Frenguelli, B.G. J. Neurochem. (2004) [Pubmed]
  2. 5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells. Garcia-Gil, M., Pesi, R., Perna, S., Allegrini, S., Giannecchini, M., Camici, M., Tozzi, M.G. Neuroscience (2003) [Pubmed]
  3. Failure of AICA riboside to limit infarct size during acute myocardial infarction in rabbits. Dorion, M., Rouleau, J., Kingma, J.G. J. Cardiovasc. Pharmacol. (1992) [Pubmed]
  4. Control of lactate utilization by extracellular pH in isolated rat liver cells. Morand, C., Remesy, C., Demigne, C. Metab. Clin. Exp. (1994) [Pubmed]
  5. Progressive cardiac dysfunction with repeated pacing-induced ischemia: protection by AICA-riboside. Young, M.A., Mullane, K.M. Am. J. Physiol. (1991) [Pubmed]
  6. 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Kurth-Kraczek, E.J., Hirshman, M.F., Goodyear, L.J., Winder, W.W. Diabetes (1999) [Pubmed]
  7. AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Kefas, B.A., Heimberg, H., Vaulont, S., Meisse, D., Hue, L., Pipeleers, D., Van de Casteele, M. Diabetologia (2003) [Pubmed]
  8. 5 '-amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway. Garcia-Gil, M., Bertini, F., Pesi, R., Voccoli, V., Tozzi, M.G., Camici, M. Nucleosides Nucleotides Nucleic Acids (2006) [Pubmed]
  9. Synthesis of guanosine and its derivatives from 5-amino-1-beta-D-ribofuranosyl-4-imidazolecarboxamide. III. Formation of a novel cycloimidazole nucleoside and its cleavage reactions. Okutsu, M., Yamazaki, A. Nucleic Acids Res. (1976) [Pubmed]
  10. Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells. Javaux, F., Vincent, M.F., Wagner, D.R., van den Berghe, G. Biochem. J. (1995) [Pubmed]
  11. Effect of 5-amino-4-imidazolecarboxamide riboside (AICA-riboside) on the purine nucleotide synthesis and growth of rat kidney cells in culture: study with [15N]aspartate. Nissim, I., Yudkoff, M., Nissim, I., States, B. J. Cell. Physiol. (1989) [Pubmed]
  12. A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. Downs, S.M., Hudson, E.R., Hardie, D.G. Dev. Biol. (2002) [Pubmed]
  13. Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells. Meisse, D., Van de Casteele, M., Beauloye, C., Hainault, I., Kefas, B.A., Rider, M.H., Foufelle, F., Hue, L. FEBS Lett. (2002) [Pubmed]
  14. Acadesine (AICA-riboside): disposition and metabolism of an adenosine-regulating agent. Dixon, R., Fujitaki, J., Sandoval, T., Kisicki, J. Journal of clinical pharmacology. (1993) [Pubmed]
  15. Intramuscular mechanisms regulating fatty acid oxidation during exercise. Winder, W.W. Adv. Exp. Med. Biol. (1998) [Pubmed]
  16. Genetic evidence for 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) as a negative effector of cytochrome terminal oxidase cbb3 production in Rhizobium etli. Soberón, M., Lopez, O., Miranda, J., Tabche, M.L., Morera, C. Mol. Gen. Genet. (1997) [Pubmed]
  17. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. Salt, I.P., Johnson, G., Ashcroft, S.J., Hardie, D.G. Biochem. J. (1998) [Pubmed]
  18. Insulinotropic action of AICA riboside. I. Insulin release by isolated islets and the perfused pancreas. Akkan, A.G., Malaisse, W.J. Diabetes Res. (1994) [Pubmed]
  19. Timely administration of AICA riboside reduces reperfusion injury in rabbits. Kingma, J.G., Simard, D., Rouleau, J.R. Cardiovasc. Res. (1994) [Pubmed]
  20. Adenosine and AICA-riboside fail to enhance microvascular endothelial preservation. Sellke, F.W., Friedman, M., Wang, S.Y., Piana, R.N., Dai, H.B., Johnson, R.G. Ann. Thorac. Surg. (1994) [Pubmed]
  21. AICA-riboside: direct quantitation in ultrafiltrates of plasma by HPLC during pharmacokinetic studies in man. Dixon, R., Fujitaki, J., Chrastil, L., Lee, J. Res. Commun. Chem. Pathol. Pharmacol. (1989) [Pubmed]
  22. Resuscitation of hemorrhagic shock with hypertonic saline/dextran or lactated Ringer's supplemented with AICA riboside. Spiers, J.P., Fabian, T.C., Kudsk, K.A., Proctor, K.G. Circ. Shock (1993) [Pubmed]
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