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Chemical Compound Review

Lopac-A-013     4-(1,3-dimethyl-2,6-dioxo-7H- purin-8...

Synonyms: CHEMBL8488, A013_SIGMA, AG-A-64642, AG-J-36991, ALBB-009371, ...
 
 
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Disease relevance of Psp-theophylline

 

High impact information on Psp-theophylline

 

Chemical compound and disease context of Psp-theophylline

 

Biological context of Psp-theophylline

  • When 8-sulfophenyltheophylline was added to the infusion, skeletal muscle vascular resistance increased significantly more than with L-nitro-arginine-methyl ester alone, but there were no further increases in hepatosplanchnic resistance [12].
  • 4. The potency of FPL 67085 was unaffected by the P1-purinoceptor antagonist, 8-sulphophenyltheophylline, was similar (IC50 0.6-3.8 nM) in human and rat washed platelets or whole blood and, in rat blood, did not change following 2-30 min incubation at 37 degrees C. 5 [13].
 

Anatomical context of Psp-theophylline

 

Associations of Psp-theophylline with other chemical compounds

 

Gene context of Psp-theophylline

 

Analytical, diagnostic and therapeutic context of Psp-theophylline

References

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  4. Antagonism of the cardiovascular effects of adenosine by caffeine or 8-(p-sulfophenyl)theophylline. Evoniuk, G., von Borstel, R.W., Wurtman, R.J. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
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  9. A retinal-derived relaxing factor mediates the hypoxic vasodilation of retinal arteries. Delaey, C., Boussery, K., Van de Voorde, J. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  10. Stimulation of interleukin-6 secretion and gene transcription in primary astrocytes by adenosine. Schwaninger, M., Neher, M., Viegas, E., Schneider, A., Spranger, M. J. Neurochem. (1997) [Pubmed]
  11. Heart/Cardiac Muscle: Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine. Reichelt, M.E., Willems, L., Peart, J.N., Ashton, K.J., Matherne, G.P., Blackburn, M.R., Headrick, J.P. Exp. Physiol. (2007) [Pubmed]
  12. Adenosine and nitric oxide regulate regional vascular resistance via interdependent and independent mechanisms during sepsis. Sam, A.D., Sharma, A.C., Rice, A.N., Ferguson, J.L., Law, W.R. Crit. Care Med. (2000) [Pubmed]
  13. Pharmacological profile of the novel P2T-purinoceptor antagonist, FPL 67085 in vitro and in the anaesthetized rat in vivo. Humphries, R.G., Tomlinson, W., Clegg, J.A., Ingall, A.H., Kindon, N.D., Leff, P. Br. J. Pharmacol. (1995) [Pubmed]
  14. Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. Meno, J.R., Crum, A.V., Winn, H.R. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
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  17. Adenosine, a cytoprotective autocoid: effects of adenosine on neutrophil plasma membrane viscosity and chemoattractant receptor display. Cronstein, B.N., Rose, F.R., Pugliese, C. Biochim. Biophys. Acta (1989) [Pubmed]
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  19. Investigation of the cellular mechanism of inhibition of formyl-methionyl-leucyl-phenylalanine-induced superoxide anion generation in rat neutrophils by 2-benzyloxybenzaldehyde. Wang, J.P., Chang, L.C., Lin, Y.L., Hsu, M.F., Chang, C.Y., Huang, L.J., Kuo, S.C. Biochem. Pharmacol. (2003) [Pubmed]
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  26. Attenuation of S-T segment elevation during repetitive coronary occlusions truly reflects the protection of ischemic preconditioning and is not an epiphenomenon. Cohen, M.V., Yang, X.M., Downey, J.M. Basic Res. Cardiol. (1997) [Pubmed]
 
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