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Chemical Compound Review

Lopac-A-013     4-(1,3-dimethyl-2,6-dioxo-7H- purin-8...

Synonyms: CHEMBL8488, A013_SIGMA, AG-A-64642, AG-J-36991, ALBB-009371, ...
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Disease relevance of Psp-theophylline


High impact information on Psp-theophylline


Chemical compound and disease context of Psp-theophylline


Biological context of Psp-theophylline

  • When 8-sulfophenyltheophylline was added to the infusion, skeletal muscle vascular resistance increased significantly more than with L-nitro-arginine-methyl ester alone, but there were no further increases in hepatosplanchnic resistance [12].
  • 4. The potency of FPL 67085 was unaffected by the P1-purinoceptor antagonist, 8-sulphophenyltheophylline, was similar (IC50 0.6-3.8 nM) in human and rat washed platelets or whole blood and, in rat blood, did not change following 2-30 min incubation at 37 degrees C. 5 [13].

Anatomical context of Psp-theophylline


Associations of Psp-theophylline with other chemical compounds


Gene context of Psp-theophylline


Analytical, diagnostic and therapeutic context of Psp-theophylline


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  13. Pharmacological profile of the novel P2T-purinoceptor antagonist, FPL 67085 in vitro and in the anaesthetized rat in vivo. Humphries, R.G., Tomlinson, W., Clegg, J.A., Ingall, A.H., Kindon, N.D., Leff, P. Br. J. Pharmacol. (1995) [Pubmed]
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  19. Investigation of the cellular mechanism of inhibition of formyl-methionyl-leucyl-phenylalanine-induced superoxide anion generation in rat neutrophils by 2-benzyloxybenzaldehyde. Wang, J.P., Chang, L.C., Lin, Y.L., Hsu, M.F., Chang, C.Y., Huang, L.J., Kuo, S.C. Biochem. Pharmacol. (2003) [Pubmed]
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