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Chemical Compound Review

Lopac-P-2278     1,3-dimethyl-8-phenyl-7H- purine-2,6-dione

Synonyms: CHEMBL62350, SureCN516432, Bio-0778, SureCN5117172, P2278_SIGMA, ...
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Disease relevance of Lopac-P-2278

  • The decrease in ectosolic and cytosolic 5'-nucleotidase activity was inhibited by 8-phenyltheophylline and pertussis toxin, and was mimicked by N6-cyclohexyladenosine, an adenosine A1 receptor agonist [1].
  • Preconditioning with 2-minute ischemia tended to limit %IS/AR (%IS/AR, 35.5 +/- 3.5%, n = 9), and that possible protection was abolished by pretreatment with 10 mg/kg 8-phenyltheophylline (8-PT), an ADO receptor antagonist (%IS/AR, 43.9 +/- 5.8%, n = 9) [2].
  • The blockade of adenosine receptors with 8 phenyltheophylline, before or after the preconditioning tachycardia, reverted its protecting effect but it did not modify infarct size in nonpreconditioned dogs [3].
  • The LAD was occluded for 20 or 30 seconds and then released, and reactive hyperemia was observed before and after 8-phenyltheophylline (7.5 mg/kg i.v.) or glibenclamide (200 micrograms/kg into the LAD) infusion [4].
  • Hypoxia was repeated before and after 8-phenyltheophylline administration (19.5, intravenously) in seven rabbits, or before and after vehicle injection in five rabbits (time control) [5].

Psychiatry related information on Lopac-P-2278


High impact information on Lopac-P-2278


Chemical compound and disease context of Lopac-P-2278


Biological context of Lopac-P-2278


Anatomical context of Lopac-P-2278


Associations of Lopac-P-2278 with other chemical compounds


Gene context of Lopac-P-2278


Analytical, diagnostic and therapeutic context of Lopac-P-2278


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  15. Adenosine modulates reactive hyperemia in rat gut. Pawlik, W.W., Hottenstein, O.D., Palen, T.E., Pawlik, T., Jacobson, E.D. J. Physiol. Pharmacol. (1993) [Pubmed]
  16. Hypoxic vasodilatation in isolated, perfused guinea-pig heart: an analysis of the underlying mechanisms. von Beckerath, N., Cyrys, S., Dischner, A., Daut, J. J. Physiol. (Lond.) (1991) [Pubmed]
  17. Inhibitory adenosine receptors in the heart: characterization by ligand binding studies and effects on beta-adrenergic receptor stimulated adenylate cyclase and membrane protein phosphorylation. Hosey, M.M., McMahon, K.K., Green, R.D. J. Mol. Cell. Cardiol. (1984) [Pubmed]
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  22. Adenosine is not essential for exercise hyperaemia in the hindlimb in conscious dogs. Koch, L.G., Britton, S.L., Metting, P.J. J. Physiol. (Lond.) (1990) [Pubmed]
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  29. Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline. Murray, S., Odupitan, A.O., Murray, B.P., Boobis, A.R., Edwards, R.J. Xenobiotica (2001) [Pubmed]
  30. Characterisation of ATP-induced facilitation of transmission in rat hippocampus. O'Kane, E.M., Stone, T.W. Eur. J. Pharmacol. (2000) [Pubmed]
  31. Endothelium-dependent sensory non-adrenergic non-cholinergic vasodilatation in rat thoracic aorta: involvement of ATP and a role for NO. Park, J.I., Shin, C.Y., Lee, Y.W., Huh, I.H., Sohn, U.D. J. Pharm. Pharmacol. (2000) [Pubmed]
  32. The vasorelaxant effects of acetate: role of adenosine, glycolysis, lyotropism, and pHi and Cai2+. Nutting, C.W., Islam, S., Ye, M.H., Batlle, D.C., Daugirdas, J.T. Kidney Int. (1992) [Pubmed]
  33. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Takagi, H., King, G.L., Ferrara, N., Aiello, L.P. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  34. Superoxide dismutase enhances ischemia-induced reactive hyperemic flow and adenosine release in dogs. A role of 5'-nucleotidase activity. Kitakaze, M., Hori, M., Takashima, S., Iwai, K., Sato, H., Inoue, M., Kitabatake, A., Kamada, T. Circ. Res. (1992) [Pubmed]
  35. Role of pertussis toxin-sensitive G protein in metabolic vasodilation of coronary microcirculation. Tanikawa, T., Kanatsuka, H., Koshida, R., Tanaka, M., Sugimura, A., Kumagai, T., Miura, M., Komaru, T., Shirato, K. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
  36. NMDA-receptor-independent effects of low magnesium: involvement of adenosine. Stone, T.W., Connick, J.H., Bartrup, J.T. Brain Res. (1990) [Pubmed]
  37. The liver protective effect of ischemic preconditioning may be mediated by adenosine. Nilsson, B., Friman, S., Wallin, M., Gustafsson, B., Delbro, D. Transpl. Int. (2000) [Pubmed]
  38. Intrahepatic adenosine triggers a hepatorenal reflex to regulate renal sodium and water excretion. Ming, Z., Smyth, D.D., Lautt, W.W. Autonomic neuroscience : basic & clinical. (2001) [Pubmed]
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