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Chemical Compound Review

Tauredon     disodium; gold(+1) cation; 2...

Synonyms: Miocrisin, Myocrisin, Myocrysine, Myochrysine, Aurothiomalate, ...
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Disease relevance of Monomercaptosuccinic acid


High impact information on Monomercaptosuccinic acid


Chemical compound and disease context of Monomercaptosuccinic acid


Biological context of Monomercaptosuccinic acid


Anatomical context of Monomercaptosuccinic acid


Associations of Monomercaptosuccinic acid with other chemical compounds


Gene context of Monomercaptosuccinic acid

  • Sixty-three patients with rheumatoid arthritis were randomly divided into 3 groups, and treated with either sodium aurothiomalate (Myocrisin), auranofin, or placebo [19].
  • Chemiluminescence was measured in the presence of GSTM from solid material and from Myocrisin ampoules [14].
  • The highest amount of virus was recovered from the pancreas of myocrisin-treated mice on day 3 p.i. This was over 500-fold higher than the virus titer found in the pancreas of mice infected with virus only [4].
  • Histochemical procedures for the mouse sperm enzymes hyaluronidase, esterase and acrosin were used to test the inhibitory effects of the low molecular weight hyaluronidase inhibitor sodium aurothiomalate (Myocrisin): hyaluronidase and esterase, but not acrosin, were inhibited [20].
  • The aim of our study is to examine the possibility for the continuation of therapy after achieving clinical improvement in patients with skin rash and stomatitis as a result of treatment with ATM (Tauredon, "Byk Gulden", Germany) [21].

Analytical, diagnostic and therapeutic context of Monomercaptosuccinic acid


  1. Requirement for macrophages for interferon to be effective against encephalomyocarditis virus infection of mice. Stebbing, N., Dawson, K.M., Lindley, I.J. Infect. Immun. (1978) [Pubmed]
  2. Immunomodification and the expression of virulence in mice by defined strains of Semliki Forest virus: the effects of myocrisin and 1-asparaginase. Bradish, C.J., Allner, K., Fitzgeorge, R. J. Gen. Virol. (1975) [Pubmed]
  3. Effect of myocrisin (sodium auro-thio-malate) on the morphogenesis of avirulent Semliki Forest virus in mouse brain: an electron microscopical study. Pathak, S., Webb, H.E. Neuropathol. Appl. Neurobiol. (1983) [Pubmed]
  4. Potentiation of coxsackievirus B3 infection in adult mice pretreated with a gold salt. Kabiri, M., Basiri, E., Kadivar, D. J. Med. Virol. (1978) [Pubmed]
  5. Effects of gold on cytokine production in vitro; increase of monocyte dependent interleukin 10 production and decrease of interferon-gamma levels. Lampa, J., Klareskog, L., Rönnelid, J. J. Rheumatol. (2002) [Pubmed]
  6. Comparison of gold levels and distribution in guinea pig serum. Kamel, H., Brown, D.H., Ottaway, J.M., Smith, W.E., Cottney, J., Lewis, A.J. Arthritis Rheum. (1978) [Pubmed]
  7. Action of sodium aurothiomalate on erythrocyte membrane. Campbell, J.M., Reglinski, J., Smith, W.E., Porter, D., Sturrock, R.D. Ann. Rheum. Dis. (1992) [Pubmed]
  8. Free thiomalate in plasma and urine of patients receiving sodium aurothiomalate. Rudge, S.R., Perrett, D., Swannell, A.J. Ann. Rheum. Dis. (1984) [Pubmed]
  9. Hypothesis for the pathogenesis of sodium aurothiomalate (Myocrisin) induced immune complex nephritis. Skrifvars, B. Scand. J. Rheumatol. (1979) [Pubmed]
  10. A reaction between captopril (a high blood pressure drug) and gold(I)-thiomalate. Isab, A.A. J. Inorg. Biochem. (1987) [Pubmed]
  11. Further studies of macrophages in relationship to avirulent Semliki Forest virus infections. Oaten, S.W., Jagelman, S., Webb, H.E. British journal of experimental pathology. (1980) [Pubmed]
  12. Inhibition of human neutrophil collagenase by gold(I) salts used in chrysotherapy. Mallya, S.K., Van Wart, H.E. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  13. Myocrisin-mediated oxidative stress. Reglinski, J., Paterson, D.E., Latimer, S., Campbell, J.M., Wilson, R., Porter, D., Sturrock, R.D., Smith, W.E. Clin. Chim. Acta (1997) [Pubmed]
  14. The effect of aurothiomalate on the oxidative burst of polymorphonuclear leukocytes varies with the quantity of drug in myocrisin ampoules. Rudkowski, R., Graham, G.G., Ziegler, J.B., Champion, G.D. J. Rheumatol. (1991) [Pubmed]
  15. Questionable effects of Myocrisin in experimental arthritis in rabbits. Reimann, I., Rasmussen, G.G. Scand. J. Rheumatol. (1975) [Pubmed]
  16. Lysosomal enzyme changes in macrophages from mice given myocrisin and infected with avirulent Semliki Forest virus. Mehta, S., Webb, H.E. British journal of experimental pathology. (1982) [Pubmed]
  17. The effect of penicillamine and 2,3-dimercaptosuccinic acid on urinary excretion and tissue distribution of gold. Aaseth, J., Jellum, E., Munthe, E. Scand. J. Rheumatol. (1980) [Pubmed]
  18. Gold and thiol compounds in the treatment of rheumatoid arthritis: excretory fate and tissue distribution of thiomalate in relation to gold after administration of myocrisin (auro-thiomalate). Jellum, E., Munthe, E., Guldal, G., Aaseth, J. Scand. J. Rheumatol. Suppl. (1979) [Pubmed]
  19. Gold levels produced by treatment with auranofin and sodium aurothiomalate. Lewis, D., Capell, H.A., McNeil, C.J., Iqbal, M.S., Brown, D.H., Smith, W.E. Ann. Rheum. Dis. (1983) [Pubmed]
  20. Histochemical evaluation of sodium aurothiomalate inhibition of mouse sperm enzymes. Waibel, R., Oldford, G.M., Ficsor, G., Ginsberg, L.C. J. Reprod. Fertil. (1984) [Pubmed]
  21. Mucocutaneous side effects and continuation of aurotherapy in patients with rheumatoid arthritis. Taukumova, L.A., Mouravjoy YuV, n.u.l.l., Gribakin, S.G. Adv. Exp. Med. Biol. (1999) [Pubmed]
  22. A comparative study of the interaction of Myocrisin with albumin and gamma-globulin. McDonald, C., Mortimer, P., McAllister, G., Gardiner, P.E., Reglinski, J., Smith, W.E. Journal of pharmaceutical and biomedical analysis. (1995) [Pubmed]
  23. Gold serum levels in children with juvenile rheumatoid arthritis. Mäkelä, A.L., Peltola, O., Mäkelä, P. Scand. J. Rheumatol. (1978) [Pubmed]
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