Disease relevance of Gold monochloride

• Three additional rabbits, not infected with HSV-1, underwent gold chloride impregnation of the corneal nerves for light microscopic documentation of corneal nerve damage induced by each procedure [1].
• It was found that in alcoholic liver disease the gold chloride reaction became weaker as hepatic fibrosis progressed (P less than 0.001) [2].
• The interaction between biofilms of Pseudomonas aeruginosa PAO1 and 0.01-5 mM gold chloride was investigated using flow-cells [3].
• By contrast, no significant association was observed between the gold chloride reaction and the degree of hepatic fibrosis in 74 specimens from patients with nonalcoholic liver disease [2].
• Several other compounds were tested for similar effects and at 5 X 10(-6)M were found to inhibit bone resorption in the order: copper sulfate greater than brown gold chloride greater than sodium aurothiomalate greater than zinc sulfate greater than sodium sulfate [4].

Psychiatry related information on Gold monochloride

• We performed gold chloride staining of coracoacromial ligaments removed at operation, observed the peripheral nerve endings in the ligament, and studied their distribution and changes with aging in order to clarify the proprioception of the shoulder joint [5].

High impact information on Gold monochloride

• Inhibition was observed with concentrations as low as 1 microgram/ml GST, 5 micrograms/ml gold chloride, and 0.1 microgram/ml auranofin, levels attainable in blood and synovium of patients [6].
• Serum levels after oral administration of 30 mg/kg of sodium aurothiomalate (Myocrisin), triethylphosphine gold chloride, or triphenylphosphine gold chloride to guinea pigs indicated that all were orally absorbed [7].
• The purpose of this study was, to quantify the stellate cell lipid droplet area in hepatic and extrahepatic stellate cells in control rats and in rats fed excess vitamin A. The stellate cells were identified by the gold chloride staining technique, specific autofluorescence of retinyl ester, and by electron microscopy [8].
• Innervation in the cornea (examined using a gold chloride technique) demonstrated a decrease in the number of corneal large axons in treated rats with neurite sprouting of these axons yielding a higher density of nerve fibers compared with controls [9].
• Gold chloride impregnation showed that the cat cornea is innervated by 16-20 radial nerve trunks that enter the mid-posterior stroma at various sites around the corneal circumference [10].

Chemical compound and disease context of Gold monochloride

• Significant increase in ovarian and uterine weight and stimulation of ovarian delta5-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) activity and elevation of serum estradiol level were observed following gold chloride (0.2 mg/kg body weight/day), s.c. administration in immature female albino rats [11].
• MU-Gold, tetrakis (trishydroxymethyl) phosphine gold(I) chloride, a novel gold compound, has cytotoxic effects against human androgen-dependent and -independent prostatic, gastric, and colonic carcinoma in cell culture and against malignant lymphoma in rodent models [12].

Biological context of Gold monochloride

• The histology of the cat anterior and posterior cruciate ligaments was studied using the modified Gairns gold chloride staining for neural elements [13].
• We demonstrate the one-step synthesis of a silica-gold nanocomposite by simultaneous hydrolysis and reduction of gold chloride [14].
• The effect of 350 mumol gold-chloride/l culture medium on cell growth of the sensitive (HE) and resistant (HEAu350) cell strain, was tested over a period of 9 days [15].
• Gold-chloride produced a dose-dependent inhibition of cell proliferation of both cell strains [16].
• Nerve-regeneration status was evaluated after weeks 2, 4, 5, 8, and 12 by gold chloride staining [17].

Anatomical context of Gold monochloride

• However, the appearance of astrocytes at the light microscopic level following immunoreaction with glial filament acidic protein antisera or Cajal's gold-chloride method is markedly different from the morphology of Golgi-impregnated or horseradish peroxidase-filled astrocytes [18].
• To further understand the mode of action of AF and to test the validity of the thiol exchange model, we have continued to study the interactions with macrophages of AF and a related gold complex, triethylphosphine gold chloride (TEPG) [19].
• The ligaments were transected and stained with hematoxylin and eosin, oil red O for fat, and a modification of Gairn's gold chloride method [20].
• We obtained human cruciate ligaments at the time of total knee replacement and from autopsy and amputation specimens, and examined histological sections of the ligaments for the presence of mechanoreceptors using the Bodian, Bielschowsky, and Ranvier gold-chloride stains for axons and nerve-endings [21].
• After 3-4 weeks, corneas stained by the gold chloride procedure showed axon terminals within the epithelial cyst and plexiform arrangements at the periphery [22].

Associations of Gold monochloride with other chemical compounds

• In vitro the bromide concentration of solutions measured by the gold chloride or rosaniline methods decreased linearly with increasing concentrations of antipyrine [23].
• Administration of gold as gold chloride [Au(III)] instead of gold sodium thiomalate [Au(I)] did not alter the excretion into bile, nor did stimulation of metallothionein, a metal-binding protein in the liver and kidney, by Cd pretreatment [24].
• Triethylphosphine gold chloride (TEPAu) is highly cytotoxic to isolated rat hepatocytes at concentrations greater than 25 microM [25].
• The macroscopic and microscopic appearance plus the distribution of neural structures within the TMJ were examined using fluorescence histochemistry (glyoxylic acid), immunohistochemistry (calcitonin gene-related peptide), silver, and gold chloride techniques [26].
• Combining the gold chloride and toluidine blue stains to investigate chick embryo neural tissue [27].

Gene context of Gold monochloride

• Thus staining techniques that have a propensity for the glial filaments such as antisera to glial fibrillary acidic protein and the gold-chloride method provide only a skeletal outline of the major processes of the protoplasmic astrocyte [18].
• Immunohistochemical staining of polyclonal S-100 protein or protein gene product 9.5 was more sensitive, specific, and reproducible compared with conventional gold chloride methods [28].
• Further the in vitro addition of gold chloride to rat PRP resulted in marked inhibition of platelet aggregation in response to both ADP and collagen [29].
• Ito cells were detected by gold chloride impregnation, as well as desmin and alpha-smooth muscle actin (alpha-SMA) immunohistochemistry [30].
• S-100 protein positive LCs were almost absent in normal controls while their number were almost lower than the corresponding cases of CIN and invasive carcinoma after gold chloride or ATPase stainings [31].

Analytical, diagnostic and therapeutic context of Gold monochloride

• Histochemical characteristics of fat-storing cells in alcoholic liver disease: a study by the gold chloride method using needle biopsy specimens of the liver [2].
• Unusual cutaneous reaction after a gold chloride patch test [32].
• After fixation, frozen sections were impregnated in gold chloride solution either at room temperature or in a microwave oven [33].
• Eight corneal buttons obtained after enucleations and keratoplasties were impregnated with gold chloride [34].
• Gold chloride technique to study articular innervation. A protocol validated through computer-assisted colorimetry [35].

References