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Chemical Compound Review

MAFENIDE ACETATE     4-(aminomethyl) benzenesulfonamide;...

Synonyms: Mafatate, Sulfamilon, Winthrocine, ARONIS24094, SureCN41627, ...
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Disease relevance of mafenide


High impact information on mafenide


Chemical compound and disease context of mafenide


Biological context of mafenide


Anatomical context of mafenide


Associations of mafenide with other chemical compounds


Gene context of mafenide

  • The results suggest that, although some of the increased ventilation of Sulfamylon is due to carbonic anhydrase inhibition, another factor, such as pain casued by the topical agent, also plays a role [21].
  • To prevent chondritis, all ears were treated prophylactically with periauricular hair shaving, daily cleaning, avoidance of pressure dressings and Sulfamylon Burn Cream [22].

Analytical, diagnostic and therapeutic context of mafenide

  • The burned ear was managed by careful, twice daily washing with minimal debridement, frequent application of mafenide acetate, and avoidance of pressure on the affected ear [23].
  • Sulfamylon cream (8.5%, BERTEK Pharmaceuticals Inc., Morgantown, W Va) was applied on the wound, with either open or occlusive dressing [3].
  • RESULTS: For patients of combatant age (20-50 years), MA was associated with a greater than 10% reduction in mortality for those with burns of 40-79% of the total body surface area (TBSA) [24].
  • Mafenide acetate as a 5% solution has a lower osmolarity, and clinical trials with this agent have shown it to be both well accepted by patients and effective in wound preparation [25].
  • Further improvements in the properties of the epidermal barrier of cultured skin substitutes may facilitate the use of Sulfamylon or other potent antimicrobial agents for the management of microbial contamination during engraftment of transplanted skin cells [17].


  1. Effects of infection on oxygen consumption and core temperature in experimental thermal injury. Aulick, L.H., McManus, A.T., Mason, A.D., Pruitt, B.A. Ann. Surg. (1986) [Pubmed]
  2. Current treatment recommendations for topical burn therapy. Monafo, W.W., West, M.A. Drugs (1990) [Pubmed]
  3. Topical Sulfamylon cream inhibits DNA and protein synthesis in the skin donor site wound. Zhang, X.J., Heggers, J.P., Chinkes, D.L., Wolf, S.E., Hawkins, H.K., Wolfe, R.R. Surgery (2006) [Pubmed]
  4. Differential inhibition of human basal keratinocyte growth to silver sulfadiazine and mafenide acetate. McCauley, R.L., Li, Y.Y., Poole, B., Evans, M.J., Robson, M.C., Heggers, J.P., Herndon, D.N. J. Surg. Res. (1992) [Pubmed]
  5. Sulfamylon allergy simulating chondritis. Kroll, S.S., Gerow, F.J. Plast. Reconstr. Surg. (1987) [Pubmed]
  6. Retrospective analysis of plasmid patterns in a study of burn unit outbreaks of infection due to Enterobacter cloacae. Markowitz, S.M., Smith, S.M., Williams, D.S. J. Infect. Dis. (1983) [Pubmed]
  7. Comparison of the effects of commonly used wound agents on epithelialization and neovascularization. Kjolseth, D., Frank, J.M., Barker, J.H., Anderson, G.L., Rosenthal, A.I., Acland, R.D., Schuschke, D., Campbell, F.R., Tobin, G.R., Weiner, L.J. J. Am. Coll. Surg. (1994) [Pubmed]
  8. Treatment of infected wounds with the antimicrobial peptide D2A21. Chalekson, C.P., Neumeister, M.W., Jaynes, J. The Journal of trauma. (2003) [Pubmed]
  9. An in vivo comparison of topical agents on wound repair. Bennett, L.L., Rosenblum, R.S., Perlov, C., Davidson, J.M., Barton, R.M., Nanney, L.B. Plast. Reconstr. Surg. (2001) [Pubmed]
  10. The antifibrinolytic activity of sulfamylon solution. Aldridge, J.H., Weisdorf, D.J., Kucan, J.O. Plast. Reconstr. Surg. (1988) [Pubmed]
  11. Topical treatment of the burn patient. Lunan, H.N. American journal of hospital pharmacy. (1975) [Pubmed]
  12. Topical Bactroban (mupirocin): efficacy in treating burn wounds infected with methicillin-resistant staphylococci. Strock, L.L., Lee, M.M., Rutan, R.L., Desai, M.H., Robson, M.C., Herndon, D.N., Heggers, J.P. The Journal of burn care & rehabilitation. (1990) [Pubmed]
  13. The efficacy of 5% Sulfamylon solution for the treatment of contaminated explanted human meshed skin grafts. Maggi, S.P., Soler, P.M., Smith, P.D., Hill, D.P., Ko, F., Robson, M.C. Burns : journal of the International Society for Burn Injuries. (1999) [Pubmed]
  14. Beneficial effect of Aloe on wound healing in an excisional wound model. Heggers, J.P., Kucukcelebi, A., Listengarten, D., Stabenau, J., Ko, F., Broemeling, L.D., Robson, M.C., Winters, W.D. Journal of alternative and complementary medicine (New York, N.Y.) (1996) [Pubmed]
  15. Mafenide acetate solution dressings: an adjunct in burn wound care. Shuck, J.M., Thorne, L.W., Cooper, C.G. The Journal of trauma. (1975) [Pubmed]
  16. Cytotoxicity to human leukocytes by topical antimicrobial agents used for burn care. Zapata-Sirvent, R.L., Hansbrough, J.F. The Journal of burn care & rehabilitation. (1993) [Pubmed]
  17. Topical sulfamylon reduces engraftment of cultured skin substitutes on athymic mice. Boyce, S.T., Supp, A.P., Swope, V.B., Warden, G.D. The Journal of burn care & rehabilitation. (1999) [Pubmed]
  18. The Potential Benefit of 5% Sulfamylon Solution in the Treatment of Acinetobacter baumannii-contaminated Traumatic War Wounds. Kucan, J.O., Heggers, J.P. Journal of burns and wounds [electronic resource]. (2005) [Pubmed]
  19. Clinical comparison of maphenide and silver sulphadiazine. Pegg, S.P., Ramsay, K., Meldrum, L., Laundy, M. Scandinavian journal of plastic and reconstructive surgery. (1979) [Pubmed]
  20. Does the addition of nystatin to 5% mafenide acetate and genitourinary irrigant solutions interfere with their antimicrobial activity? Assessment by two topical antimicrobial test assay systems. Holder, I.A., Neely, A.N. The Journal of burn care & rehabilitation. (2001) [Pubmed]
  21. Ventilatory patterns following burn injury and effect of sulfamylon. Petroff, P.A., Hander, E.W., Mason, A.D. The Journal of trauma. (1975) [Pubmed]
  22. Chondritis of the burned ear: a review. Skedros, D.G., Goldfarb, I.W., Slater, H., Rocco, J. Ear, nose, & throat journal. (1992) [Pubmed]
  23. Chondritis of the burned ear: a preventable complication. Purdue, G.F., Hunt, J.L. Am. J. Surg. (1986) [Pubmed]
  24. Survival benefit conferred by topical antimicrobial preparations in burn patients: a historical perspective. Brown, T.P., Cancio, L.C., McManus, A.T., Mason, A.D. The Journal of trauma. (2004) [Pubmed]
  25. The effect of 5% mafenide acetate solution on bacterial control in infected rat burns. Murphy, R.C., Kucan, J.O., Robson, M.C., Heggers, J.P. The Journal of trauma. (1983) [Pubmed]
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