Disease relevance of caprylic acid glyceryl ester

• We also tested the effect of reducing agents on dissolution of matched cholesterol gallstones by monooctanoin, a cholesterol solvent [1].
• Monooctanoin-associated pulmonary edema [2].
• Antibacterial effect of monocaprylin on Escherichia coli O157:H7 in apple juice [3].
• Inactivation of Enterobacter sakazakii in reconstituted infant formula by monocaprylin [4].
• Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens [5].

Psychiatry related information on caprylic acid glyceryl ester

• Results of this study indicated that monocaprylin is effective for killing E. coli O157:H7 in apple juice, but detailed sensory studies are needed to determine the organoleptic properties of apple juice containing monocaprylin [3].

High impact information on caprylic acid glyceryl ester

• In the bile duct model, the rate of monooctanoin infusion was not an important factor in accelerating dissolution time [6].
• Models of the common bile duct and gallbladder were constructed to study conditions that affect the rate of cholesterol gallstone dissolution by monooctanoin and other potential solvents [6].
• Some or all of the stones disappeared in 10 patients during biliary tract infusion of monooctanoin for 4--21 days [7].
• In addition to the snare procedure, monooctanoin was used 18 times to dissolve remaining fragments of stone and sludge that could not be snared and passed into the duodenum [8].
• Monooctanoin was infused through a cholecystostomy tube to dissolve multiple gallstones and re-establish cystic duct patency in a patient who was not a candidate for surgery [9].

Chemical compound and disease context of caprylic acid glyceryl ester

• Groups of human cholesterol gallstones were subjected to monooctanoin with and without agitation, methyl-tert-butyl ether (MTBE) with and without agitation, and monooctanoin and MTBE used in succession with agitation [10].
• NMP, which is miscible with water and monooctanoin, may have potential as a co-solvent in the design of solvent systems for gallstones [11].

Biological context of caprylic acid glyceryl ester

• In addition, the in vivo percutaneous absorption experiments showed that the blood levels of these drugs after application of aqueous gels containing 5% Sefsol 318 on rat skin were higher than those in the absence of enhancer [12].
• Percutaneous administration of DPH with Sefsol 318 to hairless rats resulted in lower diastolic blood pressure and a slightly higher heart rate with as compared to administration without the enhancer [12].
• This difference in the mode of action of Sefsol-318 and Azone may arise from the difference in the residence times of these enhancers in skin [13].

Anatomical context of caprylic acid glyceryl ester

• Monooctanoin was infused continuously at a rate of 3-4 ml/h. Monitoring of pressure with a manometer broken off at 20 cm prevented the development of excessive pressure in the common bile duct [14].

Associations of caprylic acid glyceryl ester with other chemical compounds

• The predicted exponent was very close to reported experimental values for benzoic acid, but the dissolution rate/viscosity relationship for cholesterol in aqueous monooctanoin was nonlinear with apparent exponents of -0.65 to -2 [15].
• CHS and BBIL fragments were treated with (1) a buffered, alkaline 1% ethylenediamine tetraacetate solution (BA-EDTA; pH 9.5); (2) with BA-EDTA and monooctanoin preparation (GMOC) alternately; (3) with GMOC alone, and (4) with methyl-tert-butyl ether (MTBE) [16].
• The solubilities of cholesterol and palmitic acid were greater in the N-methyl, N-ethyl and N-butylpyrrolidone derivatives than in monooctanoin [11].
• But following in vitro pretreatment of the excised skin with 5% Sefsol-318 and aqueous emulsion for 2 h, skin permeation of papaverine hydrochloride through the pretreated skin was much lower than through non-treated skin in the presence of Sefsol-318 [13].

Gene context of caprylic acid glyceryl ester

• 3. Although the Arrhenius activation energies for viscosity (3.79 kcal/mol) and dissolution rate constant (3.66 kcal/mol) were almost equal for benzoic acid, a nonlinear relationship was again observed for cholesterol in aqueous monooctanoin with approximate Ea values of 5.6-10 kcal/mol [15].

Analytical, diagnostic and therapeutic context of caprylic acid glyceryl ester

• Seventeen patients who had intrahepatic calculi underwent perfusion with monooctanoin [17].
• Monooctanoin dissolution of gallstones via a cholecystostomy tube [9].
• Because of the poor response to this treatment and the prolonged hospitalization generally required, monooctanoin is not recommended for dissolution of intrahepatic calculi [17].
• Fatal intravenous injection of monooctanoin [18].
• Dissolution of retained common bile duct stones using monooctanoin. A case report documented with cholangiography [19].

References