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Chemical Compound Review

MOCTANIN     2,3-dihydroxypropyl octanoate

Synonyms: Capmul, Monoctanoin, Monocaprylin, Imwitor 308, AC1MHWHA, ...
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Disease relevance of caprylic acid glyceryl ester


Psychiatry related information on caprylic acid glyceryl ester

  • Results of this study indicated that monocaprylin is effective for killing E. coli O157:H7 in apple juice, but detailed sensory studies are needed to determine the organoleptic properties of apple juice containing monocaprylin [3].

High impact information on caprylic acid glyceryl ester


Chemical compound and disease context of caprylic acid glyceryl ester


Biological context of caprylic acid glyceryl ester


Anatomical context of caprylic acid glyceryl ester

  • Monooctanoin was infused continuously at a rate of 3-4 ml/h. Monitoring of pressure with a manometer broken off at 20 cm prevented the development of excessive pressure in the common bile duct [14].

Associations of caprylic acid glyceryl ester with other chemical compounds


Gene context of caprylic acid glyceryl ester

  • 3. Although the Arrhenius activation energies for viscosity (3.79 kcal/mol) and dissolution rate constant (3.66 kcal/mol) were almost equal for benzoic acid, a nonlinear relationship was again observed for cholesterol in aqueous monooctanoin with approximate Ea values of 5.6-10 kcal/mol [15].

Analytical, diagnostic and therapeutic context of caprylic acid glyceryl ester


  1. Identification of gallbladder mucin-bilirubin complex in human cholesterol gallstone matrix. Effects of reducing agents on in vitro dissolution of matrix and intact gallstones. Smith, B.F., LaMont, J.T. J. Clin. Invest. (1985) [Pubmed]
  2. Monooctanoin-associated pulmonary edema. Hine, L.K., Arrowsmith, J.B., Gallo-Torres, H.E. Am. J. Gastroenterol. (1988) [Pubmed]
  3. Antibacterial effect of monocaprylin on Escherichia coli O157:H7 in apple juice. Nair, M.K., Abouelezz, H., Hoagland, T., Venkitanarayanan, K. J. Food Prot. (2005) [Pubmed]
  4. Inactivation of Enterobacter sakazakii in reconstituted infant formula by monocaprylin. Nair, M.K., Joy, J., Venkitanarayanan, K.S. J. Food Prot. (2004) [Pubmed]
  5. Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens. Nair, M.K., Joy, J., Vasudevan, P., Hinckley, L., Hoagland, T.A., Venkitanarayanan, K.S. J. Dairy Sci. (2005) [Pubmed]
  6. In vitro dissolution of cholesterol gallstones. A study of factors influencing rate and a comparison of solvents. Allen, M.J., Borody, T.J., Thistle, J.L. Gastroenterology (1985) [Pubmed]
  7. Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application. Thistle, J.L., Carlson, G.L., Hofmann, A.F., LaRusso, N.F., MacCarty, R.L., Flynn, G.L., Higuchi, W.I., Babayan, V.K. Gastroenterology (1980) [Pubmed]
  8. Bile duct stones: percutaneous transhepatic removal. Clouse, M.E., Stokes, K.R., Lee, R.G., Falchuk, K.R. Radiology. (1986) [Pubmed]
  9. Monooctanoin dissolution of gallstones via a cholecystostomy tube. Shortsleeve, M.J., Schatzki, S.C., Lee, D.L. Radiology. (1984) [Pubmed]
  10. Chemical dissolution of gallstones: in vitro studies. Oldershaw, J.H., Epstein, N.F., Potter, J.E., Clouse, M.E. Radiology. (1989) [Pubmed]
  11. Physicochemical investigations of dipolar aprotic solvents as potential cholelitholytic agents. Kennelly, P., Corrigan, O.I. J. Pharm. Pharmacol. (1987) [Pubmed]
  12. Effect of several enhancers on the skin permeation of water-soluble drugs. Okumura, M., Sugibayashi, K., Morimoto, Y. Chem. Pharm. Bull. (1989) [Pubmed]
  13. Enhanced skin permeation of papaverine by a medium chain glyceride. Okumura, M., Nakamori, Y., Sugibayashi, K., Morimoto, Y. Drug Des. Deliv. (1991) [Pubmed]
  14. The treatment of retained biliary stones with monooctanoin: report of 16 patients. Tritapepe, R., Di Padova, C., Pozzoli, M., Rovagnati, P., Montorsi, W. Am. J. Gastroenterol. (1984) [Pubmed]
  15. Importance of viscosity in the dissolution rate of cholesterol in monooctanoin solutions. Bogardus, J.B. Journal of pharmaceutical sciences. (1984) [Pubmed]
  16. Dissolution of calcified cholesterol stones and of brown and black pigment stones of the gallbladder. Leuschner, U., Wosiewitz, U., Baumgärtel, H., Leuschner, M., Iwamura, K., Klicic, X., Frenk, H. Digestion (1988) [Pubmed]
  17. Monooctanoin perfusion treatment of intrahepatic calculi. Butch, R.J., MacCarty, R.L., Mueller, P.R., Ferrucci, J.T., Simeone, J.F., Teplick, S.K., Haskin, P.H. Radiology. (1984) [Pubmed]
  18. Fatal intravenous injection of monooctanoin. Hejka, A.G., Poquette, M., Wiebe, D.A., Huntington, R.W. The American journal of forensic medicine and pathology : official publication of the National Association of Medical Examiners. (1990) [Pubmed]
  19. Dissolution of retained common bile duct stones using monooctanoin. A case report documented with cholangiography. Cassat, J.D., Shannon, G.J. South Dakota journal of medicine. (1982) [Pubmed]
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