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Chemical Compound Review

D-AP7     2-amino-7-phosphono-heptanoic acid

Synonyms: AP-7, AP-7 compound, CHEMBL274440, Bio-0271, AG-H-16540, ...
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Disease relevance of DL-2-Amino-7-phosphonoheptanoic acid


Psychiatry related information on DL-2-Amino-7-phosphonoheptanoic acid


High impact information on DL-2-Amino-7-phosphonoheptanoic acid


Chemical compound and disease context of DL-2-Amino-7-phosphonoheptanoic acid


Biological context of DL-2-Amino-7-phosphonoheptanoic acid


Anatomical context of DL-2-Amino-7-phosphonoheptanoic acid


Associations of DL-2-Amino-7-phosphonoheptanoic acid with other chemical compounds


Gene context of DL-2-Amino-7-phosphonoheptanoic acid

  • In contrast, focal pretreatment of MD with a competitive antagonist of the NMDA receptor 2-amino-7-phosphonoheptanoic acid (500 pmol) did not attenuate seizures [24].
  • The effects of the chronic intracerebroventricular (i.c.v.) infusion of the potent dicarboxylic amino acid antagonist, 2-amino-7-phosphonoheptanoic acid (APH), were examined in female rats as a prelude to the use of this compound in exploring the role of dicarboxylic amino acids in barbiturate dependence and withdrawal [25].
  • Impaired motor coordination in mice induced by 2-amino-7-phosphonoheptanoic acid (APH), glutamic acid diethyl ester (GDEE), and other compounds [26].

Analytical, diagnostic and therapeutic context of DL-2-Amino-7-phosphonoheptanoic acid


  1. Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Simon, R.P., Swan, J.H., Griffiths, T., Meldrum, B.S. Science (1984) [Pubmed]
  2. 2-Amino-7-phosphonoheptanoic acid inhibits insulin-induced convulsions and striatal aspartate accumulation in rats with frontal cortical ablation. Chapman, A.G., Engelsen, B., Meldrum, B.S. J. Neurochem. (1987) [Pubmed]
  3. The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. Wardley-Smith, B., Meldrum, B.S., Halsey, M.J. Neurosci. Lett. (1984) [Pubmed]
  4. In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers. Nakamura, M., Abe, S., Goto, Y., Chishaki, A., Akazawa, K., Kato, M. Epilepsy Res. (1994) [Pubmed]
  5. Inhibition by N-methyl-D-aspartic acid (NMDA) receptor antagonist of lordosis behavior induced by estrogen followed by progesterone or luteinizing hormone-releasing hormone (LHRH) in the rat. Gargiulo, P.A., Muñoz, V., Donoso, A.O. Physiol. Behav. (1992) [Pubmed]
  6. Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra. De Sarro, G., Meldrum, B.S., Reavill, C. Eur. J. Pharmacol. (1984) [Pubmed]
  7. Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist. Wieloch, T. Science (1985) [Pubmed]
  8. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. Wetmore, C., Olson, L., Bean, A.J. J. Neurosci. (1994) [Pubmed]
  9. Biphenyl-derivatives of 2-amino-7-phosphonoheptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonist--I. Pharmacological characterization in vitro. Urwyler, S., Laurie, D., Lowe, D.A., Meier, C.L., Müller, W. Neuropharmacology (1996) [Pubmed]
  10. Age-dependent differences in the anticonvulsant effects of 2-amino-7-phosphono-heptanoic acid or ketamine infusions into the substantia nigra of rats. Wurpel, J.N., Sperber, E.F., Moshé, S.L. Epilepsia (1992) [Pubmed]
  11. Convulsions induced by centrally administered NMDA in mice: effects of NMDA antagonists, benzodiazepines, minor tranquilizers and anticonvulsants. Moreau, J.L., Pieri, L., Prud'hon, B. Br. J. Pharmacol. (1989) [Pubmed]
  12. Effect of excitatory amino acid antagonists on the high pressure neurological syndrome in rats. Wardley-Smith, B., Meldrum, B.S. Eur. J. Pharmacol. (1984) [Pubmed]
  13. NMDA receptors in the medial zona incerta stimulate luteinizing hormone and prolactin release. Bregonzio, C., Moreno, G.N., Cabrera, R.J., Donoso, A.O. Cell. Mol. Neurobiol. (2004) [Pubmed]
  14. Inhibition of high-affinity [3H]L-proline binding to rat brain membranes by 2-amino-7-phosphonoheptanoic acid. Cordero, M.L., Negrón, A.E., Ortiz, J.G., Blanco, C., Santiago, G. Eur. J. Pharmacol. (1991) [Pubmed]
  15. 2-Amino-7-phosphonoheptanoic acid depresses gamma-motoneurons and polysynaptic reflexes in the cat spinal cord. Polc, P. Eur. J. Pharmacol. (1985) [Pubmed]
  16. Suppression of amygdaloid kindled convulsion following unilateral injection of 2-amino-7-phosphonoheptanoic acid (2-APH) into the substantia innominata of rats. Mori, N., Wada, J.A. Brain Res. (1989) [Pubmed]
  17. 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. Patel, S., Millan, M.H., Mello, L.M., Meldrum, B.S. Neurosci. Lett. (1986) [Pubmed]
  18. Modulation of the audiogenic seizure network by noradrenergic and glutamatergic receptors of the deep layers of superior colliculus. Faingold, C., Casebeer, D. Brain Res. (1999) [Pubmed]
  19. Field-potential assay of antiepileptic drugs in the hippocampal slice. Ashton, D., Willems, R., de Prins, E., Wauquier, A. Epilepsia (1988) [Pubmed]
  20. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Urwyler, S., Campbell, E., Fricker, G., Jenner, P., Lemaire, M., McAllister, K.H., Neijt, H.C., Park, C.K., Perkins, M., Rudin, M., Sauter, A., Smith, L., Wiederhold, K.H., Müller, W. Neuropharmacology (1996) [Pubmed]
  21. Excitatory amino acid receptor-mediated activation of solitarial deglutitive loci. Hashim, M.A., Bieger, D. Neuropharmacology (1989) [Pubmed]
  22. The effects of intrahippocampal ibotenic acid and their blockade by (-) 2-amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis. Aldinio, C., French, E.D., Schwarcz, R. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1983) [Pubmed]
  23. Non-NMDA but not NMDA blockade at deep prepiriform cortex protects against hippocampal cell death in status epilepticus. Kawaguchi, K., Simon, R.P. Brain Res. (1997) [Pubmed]
  24. Mediodorsal thalamus plays a critical role in the development of limbic motor seizures. Cassidy, R.M., Gale, K. J. Neurosci. (1998) [Pubmed]
  25. Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity. McCaslin, P.P., Morgan, W.W. Neuropharmacology (1986) [Pubmed]
  26. Impaired motor coordination in mice induced by 2-amino-7-phosphonoheptanoic acid (APH), glutamic acid diethyl ester (GDEE), and other compounds. Freed, W.J. Pharmacol. Biochem. Behav. (1989) [Pubmed]
  27. Neurons in the periaqueductal gray are critically involved in the neuronal network for audiogenic seizures during ethanol withdrawal. Yang, L., Long, C., Randall, M.E., Faingold, C.L. Neuropharmacology (2003) [Pubmed]
  28. Long-lasting potentiation of field potentials in primary and secondary somatosensory cortex. Kawakami, Y., Ashida, H. Brain Res. (1993) [Pubmed]
  29. A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties. Zaczek, R., Markl, A., Balm, M., Coyle, J.T. J. Neurosci. Methods (1986) [Pubmed]
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