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MeSH Review

Substantia Innominata

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Psychiatry related information on Substantia Innominata


High impact information on Substantia Innominata


Chemical compound and disease context of Substantia Innominata


Biological context of Substantia Innominata


Anatomical context of Substantia Innominata


Associations of Substantia Innominata with chemical compounds

  • Lesions of the cholinergic cells in the ventral pallidum/substantia innominata induced by ibotenic acid, depending upon their size, had significant effects on the acquisition and performance of the discrimination, without affecting the latency to collect the pellets [18].
  • In the substantia innominata, clusters of small, globular GABA-immunoreactive somata were scattered among aggregates of larger, nonimmunoreactive neurons belonging to the nucleus basalis, and the whole region showed a low to moderate number of evenly spread GABA-positive terminals [19].
  • Switching to cue-directed behavior: specific for ventral striatal dopamine but not ventral pallidum/substantia innominata gaba as revealed by a swimming-test procedure in rats [20].
  • The authors then made large kainic acid lesions in the neostriatum to reveal the target areas of PPTB-producing neurons and observed a decrease in PPTB-immunoreactive fibers in the sublenticular portion of the substantia innominata and, to much lesser extent, in the bed nucleus of the stria terminalis and central nucleus of the amygdala [21].
  • Norepinephrine acts within select basal forebrain regions to modulate behavioral state and/or state-dependent processes, including the general regions encompassing the medial septal area, the medial preoptic area, and the substantia innominata [22].

Gene context of Substantia Innominata


Analytical, diagnostic and therapeutic context of Substantia Innominata


  1. Alzheimer's disease: choline acetyltransferase activity in brain tissue from clinical and pathological subgroups. Bird, T.D., Stranahan, S., Sumi, S.M., Raskind, M. Ann. Neurol. (1983) [Pubmed]
  2. Dementia and motor neuron disease: morphometric, biochemical, and Golgi studies. Horoupian, D.S., Thal, L., Katzman, R., Terry, R.D., Davies, P., Hirano, A., DeTeresa, R., Fuld, P.A., Petito, C., Blass, J. Ann. Neurol. (1984) [Pubmed]
  3. Enkephalinergic and GABAergic modulation of motor activity in the ventral pallidum. Austin, M.C., Kalivas, P.W. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  4. Comparative effects of quisqualic and ibotenic acid-induced lesions of the substantia innominata and globus pallidus on the acquisition of a conditional visual discrimination: differential effects on cholinergic mechanisms. Robbins, T.W., Everitt, B.J., Ryan, C.N., Marston, H.M., Jones, G.H., Page, K.J. Neuroscience (1989) [Pubmed]
  5. Amino acids, glutathione, and glutathione transferase activity in the brains of patients with Alzheimer's disease. Perry, T.L., Yong, V.W., Bergeron, C., Hansen, S., Jones, K. Ann. Neurol. (1987) [Pubmed]
  6. Essential tremor associated with focal nonnigral Lewy bodies: a clinicopathologic study. Louis, E.D., Honig, L.S., Vonsattel, J.P., Maraganore, D.M., Borden, S., Moskowitz, C.B. Arch. Neurol. (2005) [Pubmed]
  7. Distribution of estrogen receptor-immunoreactive cells in the sheep brain. Lehman, M.N., Ebling, F.J., Moenter, S.M., Karsch, F.J. Endocrinology (1993) [Pubmed]
  8. Changes in muscarinic binding in distant brain regions showing neuronal losses after folic acid injections into the substantia innominata. Wong, P.T., McGeer, E.G., Singh, K., McGeer, P.L. J. Neurochem. (1983) [Pubmed]
  9. Effect of GABAergic transmission in the subpallidal region on the hypermotility response to the administration of excitatory amino acids and picrotoxin into the nucleus accumbens. Shreve, P.E., Uretsky, N.J. Neuropharmacology (1988) [Pubmed]
  10. Evidence that projections from substantia innominata to zona incerta and mesencephalic locomotor region contribute to locomotor activity. Mogenson, G.J., Swanson, L.W., Wu, M. Brain Res. (1985) [Pubmed]
  11. Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Baker, G.B., Reynolds, G.P. Neurosci. Lett. (1989) [Pubmed]
  12. Atrophy of the substantia innominata on magnetic resonance imaging and response to donepezil treatment in Alzheimer's disease. Hanyu, H., Tanaka, Y., Sakurai, H., Takasaki, M., Abe, K. Neurosci. Lett. (2002) [Pubmed]
  13. The sigma ligand JO 1784 prevents trimethyltin-induced behavioural and sigma-receptor dysfunction in the rat. O'Connell, A.W., Earley, B., Leonard, B.E. Pharmacol. Toxicol. (1996) [Pubmed]
  14. Distribution and colocalization of choline acetyltransferase immunoreactivity and NADPH diaphorase reactivity in neurons within the medial septum and diagonal band of Broca in the rat basal forebrain. Kitchener, P.D., Diamond, J. J. Comp. Neurol. (1993) [Pubmed]
  15. Functional anatomy of chemical senses in the alert monkey revealed by positron emission tomography. Kobayashi, M., Sasabe, T., Takeda, M., Kondo, Y., Yoshikubo, S., Imamura, K., Onoe, H., Sawada, T., Watanabe, Y. Eur. J. Neurosci. (2002) [Pubmed]
  16. Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity. Marazioti, A., Kastellakis, A., Antoniou, K., Papasava, D., Thermos, K. Psychopharmacology (Berl.) (2005) [Pubmed]
  17. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system. McKinney, M., Coyle, J.T., Hedreen, J.C. J. Comp. Neurol. (1983) [Pubmed]
  18. Comparative functions of the central noradrenergic, dopaminergic and cholinergic systems. Robbins, T.W., Everitt, B.J. Neuropharmacology (1987) [Pubmed]
  19. Distribution of GABA-immunoreactive neurons in the basal ganglia of the squirrel monkey (Saimiri sciureus). Smith, Y., Parent, A., Seguela, P., Descarries, L. J. Comp. Neurol. (1987) [Pubmed]
  20. Switching to cue-directed behavior: specific for ventral striatal dopamine but not ventral pallidum/substantia innominata gaba as revealed by a swimming-test procedure in rats. van den Bos, R., Cools, A.R. Neuroscience (2003) [Pubmed]
  21. Third group of neostriatofugal neurons: neurokinin B-producing neurons that send axons predominantly to the substantia innominata. Furuta, T., Mori, T., Lee, T., Kaneko, T. J. Comp. Neurol. (2000) [Pubmed]
  22. Organization of noradrenergic efferents to arousal-related basal forebrain structures. España, R.A., Berridge, C.W. J. Comp. Neurol. (2006) [Pubmed]
  23. Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease. Ruberg, M., Rieger, F., Villageois, A., Bonnet, A.M., Agid, Y. Brain Res. (1986) [Pubmed]
  24. Characterization and localization of galanin receptors in human entorhinal cortex. Deecher, D.C., Mash, D.C., Staley, J.K., Mufson, E.J. Regul. Pept. (1998) [Pubmed]
  25. Neuropeptide localisation in the substantia innominata and adjacent regions of the human brain. Candy, J.M., Perry, R.H., Thompson, J.E., Johnson, M., Oakley, A.E. J. Anat. (1985) [Pubmed]
  26. Cu, Zn- and Mn-superoxide dismutase levels in brains of patients with schizophrenic psychosis. Michel, T.M., Thome, J., Martin, D., Nara, K., Zwerina, S., Tatschner, T., Weijers, H.G., Koutsilieri, E. Journal of neural transmission (Vienna, Austria : 1996) (2004) [Pubmed]
  27. Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons. Harkany, T., Härtig, W., Berghuis, P., Dobszay, M.B., Zilberter, Y., Edwards, R.H., Mackie, K., Ernfors, P. Eur. J. Neurosci. (2003) [Pubmed]
  28. Effects of glutamate agonist versus procaine microinjections into the basal forebrain cholinergic cell area upon gamma and theta EEG activity and sleep-wake state. Cape, E.G., Jones, B.E. Eur. J. Neurosci. (2000) [Pubmed]
  29. Muscarinic and GABAA receptors modulate acetylcholine release in feline basal forebrain. Vazquez, J., Baghdoyan, H.A. Eur. J. Neurosci. (2003) [Pubmed]
  30. Antisense oligodeoxynucleotide-induced suppression of basal forebrain NMDA-NR1 subunits selectively impairs visual attentional performance in rats. Turchi, J., Sarter, M. Eur. J. Neurosci. (2001) [Pubmed]
  31. Substantia innominata: critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat. Swerdlow, N.R., Swanson, L.W., Koob, G.F. Neurosci. Lett. (1984) [Pubmed]
  32. The synchronizing influence of Substantia Innominata on the thalamus of the cat. Mariotti, M., Gritti, I., Mancia, M. Journal of sleep research. (2001) [Pubmed]
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