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Chemical Compound Review

Procilex     3-(3,5-dichlorophenyl)-1,5- dimethyl-3...

Synonyms: Kenolex, Salithiex, Sumilex, Sumisclex, Procymidon, ...
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Disease relevance of Sumilex


High impact information on Sumilex


Biological context of Sumilex

  • In addition, perinatal procymidone treatment had a marked effect on the histology of the lateral and ventral prostatic and seminal vesicular tissues of the offspring (at 50 mg kg-1 day-1 and above) [5].
  • In vivo, maternal procymidone exposure at 0, 25, 50, 100, or 200 mg kg-1 day-1 during gestation and early lactation (gestational day 14 to postnatal day 3) altered reproductive development of male offspring at all dosage levels tested [5].
  • Fish exposed for 14 days to procymidone and then placed for 14 days in clean water showed nearly complete decontamination of the liver, but MT concentrations remained high [6].
  • Procymidone 100 muM stimulated cell growth from day 3 up to day 12 and raised the level of pS2 on day 3 [7].

Anatomical context of Sumilex

  • In summary, the antiandrogenic activity of procymidone was demonstrated in vivo and in vitro in cell lines transfected with hAR [5].
  • In summary, the results of the study clearly support the idea that the estrogenic activity of procymidone in primary cultured trout hepatocytes is mediated by ROS production, and that this activity is similar to that of the ligand-independent ER activation involving MAPK [8].
  • Procymidone significantly inhibited TP-induced re-growth of accessory sex organs at 25mg/kg per day and above, whereas glans penis weight significantly decreased (to 69% of the control), but only at 100 mg/kg per day [9].

Associations of Sumilex with other chemical compounds


Gene context of Sumilex

  • Thus, procymidone does not bind the c-Neu membrane receptor, excluding this indirect ER activation pathway [7].
  • Estrogenic effect of procymidone through activation of MAPK in MCF-7 breast carcinoma cell line [7].
  • The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro [5].
  • The aim of this study was to investigate the effects of chemical stress induced by the dicarboximide fungicide procymidone on hepatic structure, MT content and antioxidative defences (catalase and glutathione reductase activities and glutathione content) in the common fish Rutilus rutilus [6].
  • This suggests a difference between the rat and mouse in the response of the Leydig cell to the LH stimulation associated with procymidone administration [1].

Analytical, diagnostic and therapeutic context of Sumilex

  • Plants were sprayed with Sumisclex 50 WP (1077.5 g of ai/ha) 52 days after the transplantation, and sampling was carried out daily during two different periods of 6 and 5 consecutive days, respectively, around the two harvest days (days 12 and 28 after the treatment) [14].


  1. Species-specific mechanism in rat Leydig cell tumorigenesis by procymidone. Murakami, M., Hosokawa, S., Yamada, T., Harakawa, M., Ito, M., Koyama, Y., Kimura, J., Yoshitake, A., Yamada, H. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  2. Effects of procymidone, fludioxonil and pyrimethanil on two non-target aquatic plants. Verdisson, S., Couderchet, M., Vernet, G. Chemosphere (2001) [Pubmed]
  3. The combined effects of vinclozolin and procymidone do not deviate from expected additivity in vitro and in vivo. Nellemann, C., Dalgaard, M., Lam, H.R., Vinggaard, A.M. Toxicol. Sci. (2003) [Pubmed]
  4. Induction and suppression of cytochrome P450 isoenzymes and generation of oxygen radicals by procymidone in liver, kidney and lung of CD1 mice. Sapone, A., Affatato, A., Canistro, D., Broccoli, M., Trespidi, S., Pozzetti, L., Biagi, G.L., Cantelli-Forti, G., Paolini, M. Mutat. Res. (2003) [Pubmed]
  5. The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro. Ostby, J., Kelce, W.R., Lambright, C., Wolf, C.J., Mann, P., Gray, L.E. Toxicology and industrial health. (1999) [Pubmed]
  6. Metallothionein induction related to hepatic structural perturbations and antioxidative defences in roach (Rutilus rutilus) exposed to the fungicide procymidone. Paris-Palacios, S., Biagianti-Risbourg, S., Vernet, G. Biomarkers (2003) [Pubmed]
  7. Estrogenic effect of procymidone through activation of MAPK in MCF-7 breast carcinoma cell line. Radice, S., Chiesara, E., Frigerio, S., Fumagalli, R., Parolaro, D., Rubino, T., Marabini, L. Life Sci. (2006) [Pubmed]
  8. Estrogenic activity of procymidone in rainbow trout (Oncorhynchus mykiss) hepatocytes: a possible mechanism of action. Radice, S., Fumagalli, R., Chiesara, E., Ferraris, M., Frigerio, S., Marabini, L. Chem. Biol. Interact. (2004) [Pubmed]
  9. Comparison of anti-androgenic activity of flutamide, vinclozolin, procymidone, linuron, and p, p'-DDE in rodent 10-day Hershberger assay. Kang, I.H., Kim, H.S., Shin, J.H., Kim, T.S., Moon, H.J., Kim, I.Y., Choi, K.S., Kil, K.S., Park, Y.I., Dong, M.S., Han, S.Y. Toxicology (2004) [Pubmed]
  10. Analysis of thiabendazole and procymidone in fruits and vegetables by capillary electrophoresis-electrospray mass spectrometry. Rodríguez, R., Picó, Y., Font, G., Mañes, J. Journal of chromatography. A. (2002) [Pubmed]
  11. Pesticide residues in grapes, wine, and their processing products. Cabras, P., Angioni, A. J. Agric. Food Chem. (2000) [Pubmed]
  12. Differential pulse polarographic determination of procymidone in formulations and wine. Sreedhar, N.Y., Babu, T.R., Samatha, K., Sujatha, D., Thriveni, T. Journal of AOAC International. (2002) [Pubmed]
  13. Estradiol and resveratrol stimulating effect on osteocalcin, but not osteonectin and collagen-1alpha gene expression in primary culture of rat calvarial osteoblast-like cells. Rucinski, M., Ziolkowska, A., Hochol, A., Pucher, A., Macchi, C., Belloni, A.S., Nussdorfer, G.G., Malendowicz, L.K. Int. J. Mol. Med. (2006) [Pubmed]
  14. Residue levels, decline curves, and plantation distribution of procymidone in green beans grown in greenhouse. Castillo-Sánchez, J., Aguilera-Del Real, A., Rodriguez-Sánchez, M., Valverde-García, A. J. Agric. Food Chem. (2000) [Pubmed]
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