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Chemical Compound Review

AC1L9V6H     (2S)-2-[[(2S,3S,4S)-2-amino- 4-hydroxy-4-(5...

Synonyms: Dipeptide Nikkomycins X & Z
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  1. A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development. Liu, G., Tian, Y., Yang, H., Tan, H. Mol. Microbiol. (2005) [Pubmed]
  2. Use of the chitin-synthesis inhibitor nikkomycin to treat disseminated candidiasis in mice. Becker, J.M., Marcus, S., Tallock, J., Miller, D., Krainer, E., Khare, R.K., Naider, F. J. Infect. Dis. (1988) [Pubmed]
  3. Efficacy of nikkomycin Z against experimental pulmonary blastomycosis. Clemons, K.V., Stevens, D.A. Antimicrob. Agents Chemother. (1997) [Pubmed]
  4. Efficacy of nikkomycin Z in the treatment of murine histoplasmosis. Graybill, J.R., Najvar, L.K., Bocanegra, R., Hector, R.F., Luther, M.F. Antimicrob. Agents Chemother. (1998) [Pubmed]
  5. Evaluation of nikkomycins X and Z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis. Hector, R.F., Zimmer, B.L., Pappagianis, D. Antimicrob. Agents Chemother. (1990) [Pubmed]
  6. Chitin synthase 1 plays a major role in cell wall biogenesis in Neurospora crassa. Yarden, O., Yanofsky, C. Genes Dev. (1991) [Pubmed]
  7. Septins, under Cla4p regulation, and the chitin ring are required for neck integrity in budding yeast. Schmidt, M., Varma, A., Drgon, T., Bowers, B., Cabib, E. Mol. Biol. Cell (2003) [Pubmed]
  8. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Kraus, P.R., Fox, D.S., Cox, G.M., Heitman, J. Mol. Microbiol. (2003) [Pubmed]
  9. Identification of cellular proteins involved in nikkomycin production in Streptomyces tendae Tü901. Möhrle, V., Roos, U., Bormann, C. Mol. Microbiol. (1995) [Pubmed]
  10. Histidine aminotransferase activity in Streptomyces tendae and its correlation with nikkomycin production. Roos, U., Mattern, S., Schrempf, H., Bormann, C. FEMS Microbiol. Lett. (1992) [Pubmed]
  11. Improvement of nikkomycin production by enhanced copy of sanU and sanV in Streptomyces ansochromogenes and characterization of a novel glutamate mutase encoded by sanU and sanV. Li, Y., Ling, H., Li, W., Tan, H. Metab. Eng. (2005) [Pubmed]
  12. Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins. Cabib, E. Antimicrob. Agents Chemother. (1991) [Pubmed]
  13. Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans. Bormann, C., Möhrle, V., Bruntner, C. J. Bacteriol. (1996) [Pubmed]
  14. A study of N- and P-dependence of nikkomycin production in continuous culture with immobilized cells. Trück, H.U., Chmiel, H., Hammes, W.P., Trösch, W. Appl. Microbiol. Biotechnol. (1990) [Pubmed]
  15. Formation of a new cell wall by protoplasts of Candida albicans: effect of papulacandin B, tunicamycin and Nikkomycin. Elorza, M.V., Murgui, A., Rico, H., Miragall, F., Sentandreu, R. J. Gen. Microbiol. (1987) [Pubmed]
  16. In vitro antifungal activity of nikkomycin Z in combination with fluconazole or itraconazole. Li, R.K., Rinaldi, M.G. Antimicrob. Agents Chemother. (1999) [Pubmed]
  17. Comparison of nikkomycin Z with amphotericin B and itraconazole for treatment of histoplasmosis in a murine model. Goldberg, J., Connolly, P., Schnizlein-Bick, C., Durkin, M., Kohler, S., Smedema, M., Brizendine, E., Hector, R., Wheat, J. Antimicrob. Agents Chemother. (2000) [Pubmed]
  18. Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens. Stevens, D.A. Antimicrob. Agents Chemother. (2000) [Pubmed]
  19. The Streptomyces tendae Tü901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis. Bruntner, C., Bormann, C. Eur. J. Biochem. (1998) [Pubmed]
  20. Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo. Gaughran, J.P., Lai, M.H., Kirsch, D.R., Silverman, S.J. J. Bacteriol. (1994) [Pubmed]
  21. Defects in assembly of the extracellular matrix are responsible for altered morphogenesis of a Candida albicans phr1 mutant. Popolo, L., Vai, M. J. Bacteriol. (1998) [Pubmed]
  22. Insect chitin synthase cDNA sequence, gene organization and expression. Tellam, R.L., Vuocolo, T., Johnson, S.E., Jarmey, J., Pearson, R.D. Eur. J. Biochem. (2000) [Pubmed]
  23. Nikkomycin Z supersensitivity of an echinocandin-resistant mutant of Saccharomyces cerevisiae. el-Sherbeini, M., Clemas, J.A. Antimicrob. Agents Chemother. (1995) [Pubmed]
  24. Mutation affecting peptide bond formation in nikkomycin biosynthesis. Engel, P., Ullah, A.H. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
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