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Chemical Compound Review

Aminoimidazole     3H-imidazol-4-amine

Synonyms: PubChem19885, SureCN72511, SureCN164378, AG-K-81480, CHEBI:16607, ...
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Disease relevance of Aminoimidazole


High impact information on Aminoimidazole


Chemical compound and disease context of Aminoimidazole


Biological context of Aminoimidazole


Anatomical context of Aminoimidazole

  • PURPOSE: The aim of the present work is to describe the inhibitory properties of LY301875 and LY303336, two polysubstituted 4-aminoimidazole AT1 receptor antagonists, on CHO cells expressing human recombinant AT1 receptors [15].
  • Either saline, 5 mM 8-bromo-5'-AMP (tributyryl-AMP), or 30 mM N6, 2', 3'-tributyryl-5'-AMP (tributyryl-AMP), 5 mM 5-amino-4-imidazole carboxamide riboside (AICAr) as a positive reference, was infused at 0.1 ml/kg/min in the left femoral vein throughout the experiment [16].

Associations of Aminoimidazole with other chemical compounds

  • We have cloned and sequenced the Schizosaccharomyces pombe ade10 gene encoding 5-phosphoribosyl-4-carboxamide 5-aminoimidazole transformylase inosine monophosphate cyclohydrolase [17].
  • The purK and pur6 from these organisms are responsible for the activity of 5'-phosphoribosyl- 5-amino-4-imidazole carboxylase which is involved in de novo purine biosynthesis [18].
  • Derepression requires the transcriptional activators Bas1 and Pho2, as well as the biosynthetic intermediates 5'-phosphoribosyl-4-succinocarboxamide-5-aminoimidazole (SAICAR) and 5'-phosphoribosyl-4-carboxamide- 5-aminoimidazole (AICAR) [19].

Analytical, diagnostic and therapeutic context of Aminoimidazole


  1. ZTP (5-amino 4-imidazole carboxamide riboside 5'-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency. Bochner, B.R., Ames, B.N. Cell (1982) [Pubmed]
  2. Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat. Galiñanes, M., Mullane, K.M., Bullough, D., Hearse, D.J. Circulation (1992) [Pubmed]
  3. Biosynthesis of the pyrimidine moiety of thiamin in Escherichia coli: incorporation of stable isotope-labeled glycines. White, R.H., Rudolph, F.B. Biochemistry (1979) [Pubmed]
  4. Protection against injury during ischemia and reperfusion by acadesine derivatives GP-1-468 and GP-1-668. Studies in the transplanted rat heart. Galiñanes, M., Zhai, X., Bullough, D., Mullane, K.M., Hearse, D.J. J. Thorac. Cardiovasc. Surg. (1995) [Pubmed]
  5. Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy. Li, H.L., Yin, R., Chen, D., Liu, D., Wang, D., Yang, Q., Dong, Y.G. J. Cell. Biochem. (2007) [Pubmed]
  6. Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart. Galiñanes, M., Bullough, D., Mullane, K.M., Hearse, D.J. Circulation (1992) [Pubmed]
  7. Inhibition of Fructose-1,6-bisphosphatase by Aminoimidazole Carboxamide Ribotide Prevents Growth of Salmonella enterica purH Mutants on Glycerol. Dougherty, M.J., Boyd, J.M., Downs, D.M. J. Biol. Chem. (2006) [Pubmed]
  8. AMP-activated protein kinase plays a role in the control of food intake. Andersson, U., Filipsson, K., Abbott, C.R., Woods, A., Smith, K., Bloom, S.R., Carling, D., Small, C.J. J. Biol. Chem. (2004) [Pubmed]
  9. A highly efficient solid-phase synthesis of 1,3-substituted xanthines. He, R., Lam, Y. Journal of combinatorial chemistry. (2005) [Pubmed]
  10. Isoxazolines as potent antagonists of the integrin alpha(v)beta(3). Pitts, W.J., Wityak, J., Smallheer, J.M., Tobin, A.E., Jetter, J.W., Buynitsky, J.S., Harlow, P.P., Solomon, K.A., Corjay, M.H., Mousa, S.A., Wexler, R.R., Jadhav, P.K. J. Med. Chem. (2000) [Pubmed]
  11. AICA-riboside: safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent. Dixon, R., Gourzis, J., McDermott, D., Fujitaki, J., Dewland, P., Gruber, H. Journal of clinical pharmacology. (1991) [Pubmed]
  12. Which of caffeine's chemical relatives are able to evoke contractures in mammalian heart? Chapman, R.A., Leoty, C. Recent advances in studies on cardiac structure and metabolism. (1975) [Pubmed]
  13. Synthesis and structure-activity relationships of new cephalosporins with aminoimidazoles at C-7. Effect of the pKa of the C-7 aminoimidazole on antibacterial spectrum and beta-lactamase stability. Jung, F., Boucherot, D., Delvare, C., Olivier, A., Davies, G.M., Betts, M.J., Brown, R., Stevenson, R., Joseph, M., Kingston, J.F. J. Antibiot. (1993) [Pubmed]
  14. Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. Hattori, Y., Suzuki, K., Hattori, S., Kasai, K. Hypertension (2006) [Pubmed]
  15. Inhibition of angiotensin II-induced inositol phosphate production by triacid nonpeptide antagonists in CHO cells expressing human AT1 receptors. Vanderheyden, P.M., Verheijen, I., Fierens, F.L., DeBacker, J.P., Vauquelin, G. Pharm. Res. (2000) [Pubmed]
  16. Effects of adenine nucleotide analogues on myocardial dysfunction during reperfusion after ischemia in dogs. Nakai, T., Kano, S., Satoh, K., Hoshi, K., Ichihara, K. J. Cardiovasc. Pharmacol. (1996) [Pubmed]
  17. Molecular cloning and sequence analysis of the Schizosaccharomyces pombe ade10+ gene. Liedtke, C., Schmidt, H. Yeast (1998) [Pubmed]
  18. Cloning, sequencing and expression of a Pasteurella haemolytica A1 gene encoding a PurK-like protein. Chang, Y.F., Ma, D.P., Young, R., Struck, D.K. DNA Seq. (1993) [Pubmed]
  19. DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces cerevisiae. Som, I., Mitsch, R.N., Urbanowski, J.L., Rolfes, R.J. Eukaryotic Cell (2005) [Pubmed]
  20. A sensitive assay for the aminoimidazole-containing drug GP531 in plasma using liquid chromatography with amperometric electrochemical detection: a new class of electroactive compounds. Chen, L.S., Fujitaki, J.M., Dixon, R. Journal of pharmaceutical and biomedical analysis. (1996) [Pubmed]
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