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Chemical Compound Review

AC1NSK5Z     (2S)-2-[[(2S)-2-[[(2S)-6- amino-2-[[(2S)-2...

Synonyms: Insulin-Like Growth Factor-2
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Disease relevance of Insulin-Like Growth Factor-2


Psychiatry related information on Insulin-Like Growth Factor-2


High impact information on Insulin-Like Growth Factor-2

  • The paternally expressed gene insulin-like growth-factor 2 (Igf2) is separated by approximately 100 kb from the maternally expressed noncoding gene H19 on mouse distal chromosome 7 [7].
  • Here we used a GAL4 knock-in approach as well as the chromosome conformation capture technique to show that the differentially methylated regions in the imprinted genes Igf2 and H19 interact in mice [7].
  • These results suggest that increased in utero expression of paternal INS or IGF2 due to the class I INS VNTR allele may predispose offspring to postnatal fat deposition [8].
  • Finally, we have genetically and physically mapped Mash2 to the distal region of chromosome 7, within a cluster of imprinted genes, including insulin-2, insulin-like growth factor-2 and H19 [9].
  • To study insulin-like growth factor 2 (IGF2) imprinting in BWS (Beckwith-Wiedemann syndrome, an overgrowth syndrome associated with Wilms and other embryonal tumours), we examined allele-specific expression using an Apal polymorphism in the 3' untranslated region of IGF2 [1].

Chemical compound and disease context of Insulin-Like Growth Factor-2


Biological context of Insulin-Like Growth Factor-2


Anatomical context of Insulin-Like Growth Factor-2


Associations of Insulin-Like Growth Factor-2 with other chemical compounds


Gene context of Insulin-Like Growth Factor-2


Analytical, diagnostic and therapeutic context of Insulin-Like Growth Factor-2


  1. Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome. Weksberg, R., Shen, D.R., Fei, Y.L., Song, Q.L., Squire, J. Nat. Genet. (1993) [Pubmed]
  2. Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. Prawitt, D., Enklaar, T., Gärtner-Rupprecht, B., Spangenberg, C., Oswald, M., Lausch, E., Schmidtke, P., Reutzel, D., Fees, S., Lucito, R., Korzon, M., Brozek, I., Limon, J., Housman, D.E., Pelletier, J., Zabel, B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis. Ritter, M.R., Dorrell, M.I., Edmonds, J., Friedlander, S.F., Friedlander, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Imprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith-Wiedemann syndrome. Joyce, J.A., Lam, W.K., Catchpoole, D.J., Jenks, P., Reik, W., Maher, E.R., Schofield, P.N. Hum. Mol. Genet. (1997) [Pubmed]
  5. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human. Monk, D., Sanches, R., Arnaud, P., Apostolidou, S., Hills, F.A., Abu-Amero, S., Murrell, A., Friess, H., Reik, W., Stanier, P., Constância, M., Moore, G.E. Hum. Mol. Genet. (2006) [Pubmed]
  6. Association between the insulin-like growth factor 2 gene (IGF2) and scores on the Eating Attitudes Test in nonclinical subjects: a family-based study. Bachner-Melman, R., Zohar, A.H., Nemanov, L., Heresco-Levy, U., Gritsenko, I., Ebstein, R.P. The American journal of psychiatry. (2005) [Pubmed]
  7. Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops. Murrell, A., Heeson, S., Reik, W. Nat. Genet. (2004) [Pubmed]
  8. Paternal transmission of the very common class I INS VNTR alleles predisposes to childhood obesity. Le Stunff, C., Fallin, D., Bougnères, P. Nat. Genet. (2001) [Pubmed]
  9. Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Guillemot, F., Caspary, T., Tilghman, S.M., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Anderson, D.J., Joyner, A.L., Rossant, J., Nagy, A. Nat. Genet. (1995) [Pubmed]
  10. Gastric cancer: the role of insulin-like growth factor 2 (IGF 2) and its receptors (IGF 1R and M6-P/IGF 2R). Pavelić, K., Kolak, T., Kapitanović, S., Radosević, S., Spaventi, S., Kruslin, B., Pavelić, J. J. Pathol. (2003) [Pubmed]
  11. IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome. Ohlsson, R., Nyström, A., Pfeifer-Ohlsson, S., Töhönen, V., Hedborg, F., Schofield, P., Flam, F., Ekström, T.J. Nat. Genet. (1993) [Pubmed]
  12. Disruption of imprinting caused by deletion of the H19 gene region in mice. Leighton, P.A., Ingram, R.S., Eggenschwiler, J., Efstratiadis, A., Tilghman, S.M. Nature (1995) [Pubmed]
  13. An enhancer deletion affects both H19 and Igf2 expression. Leighton, P.A., Saam, J.R., Ingram, R.S., Stewart, C.L., Tilghman, S.M. Genes Dev. (1995) [Pubmed]
  14. Insulin-like growth factor 2 and short-range stimulatory loops in control of human placental growth. Ohlsson, R., Holmgren, L., Glaser, A., Szpecht, A., Pfeifer-Ohlsson, S. EMBO J. (1989) [Pubmed]
  15. T-cell receptor alpha-chain gene is split in a human T-cell leukemia cell line with a t(11;14)(p15;q11). Le Beau, M.M., McKeithan, T.W., Shima, E.A., Goldman-Leikin, R.E., Chan, S.J., Bell, G.I., Rowley, J.D., Diaz, M.O. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  16. Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity. Jones, B.K., Levorse, J., Tilghman, S.M. Hum. Mol. Genet. (2001) [Pubmed]
  17. Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans. Forné, T., Oswald, J., Dean, W., Saam, J.R., Bailleul, B., Dandolo, L., Tilghman, S.M., Walter, J., Reik, W. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Wutz, A., Theussl, H.C., Dausman, J., Jaenisch, R., Barlow, D.P., Wagner, E.F. Development (2001) [Pubmed]
  19. DNA demethylation reactivates a subset of imprinted genes in uniparental mouse embryonic fibroblasts. El Kharroubi, A., Piras, G., Stewart, C.L. J. Biol. Chem. (2001) [Pubmed]
  20. Variants of trophic factors and expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy. Patel, R., Lim, D.S., Reddy, D., Nagueh, S.F., Lutucuta, S., Sole, M.J., Zoghbi, W.A., Quiñones, M.A., Roberts, R., Marian, A.J. J. Mol. Cell. Cardiol. (2000) [Pubmed]
  21. Potent inhibition of breast cancer cell lines by the isoflavonoid kievitone: comparison with genistein. Hoffman, R. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  22. Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2. Zemel, S., Bartolomei, M.S., Tilghman, S.M. Nat. Genet. (1992) [Pubmed]
  23. Deletion of the H19 transcription unit reveals the existence of a putative imprinting control element. Ripoche, M.A., Kress, C., Poirier, F., Dandolo, L. Genes Dev. (1997) [Pubmed]
  24. Relaxation of insulin-like growth factor 2 imprinting and discordant methylation at KvDMR1 in two first cousins affected by Beckwith-Wiedemann and Klippel-Trenaunay-Weber syndromes. Sperandeo, M.P., Ungaro, P., Vernucci, M., Pedone, P.V., Cerrato, F., Perone, L., Casola, S., Cubellis, M.V., Bruni, C.B., Andria, G., Sebastio, G., Riccio, A. Am. J. Hum. Genet. (2000) [Pubmed]
  25. Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Charalambous, M., Smith, F.M., Bennett, W.R., Crew, T.E., Mackenzie, F., Ward, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  26. Imprinted genes in liver carcinogenesis. De Souza, A.T., Yamada, T., Mills, J.J., Jirtle, R.L. FASEB J. (1997) [Pubmed]
  27. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Gaunt, T.R., Cooper, J.A., Miller, G.J., Day, I.N., O'Dell, S.D. Hum. Mol. Genet. (2001) [Pubmed]
  28. Detection of anti-sense transcripts of the insulin-like growth factor-2 gene in Wilms' tumor. Baccarini, P., Fiorentino, M., D'Errico, A., Mancini, A.M., Grigioni, W.F. Am. J. Pathol. (1993) [Pubmed]
  29. Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2. Hartnell, A., Heinemann, A., Conroy, D.M., Wait, R., Sturm, G.J., Caversaccio, M., Jose, P.J., Williams, T.J. J. Immunol. (2004) [Pubmed]
  30. Somatomedin levels in pregnancy: longitudinal study in healthy subjects and patients with growth hormone deficiency. Hall, K., Enberg, G., Hellem, E., Lundin, G., Ottosson-Seeberger, A., Sara, V., Trygstad, O., Ofverholm, U. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
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