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Chemical Compound Review

Thiosulfil     4-amino-N-(5-methyl-1,3,4- thiadiazol-2...

Synonyms: Methazol, Microsul, Sulfstat, Tetracid, Thidicur, ...
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Disease relevance of Sulphamethizole

  • CONCLUSIONS: We found no increased risk of congenital malformation, stillbirth or pre-term birth, and no association between use of sulfamethizole late in pregnancy and risk of neonatal jaundice [1].
  • The usefulness of sulfamethizole capsules containing contrast medium in gastric emptying tests for functional dyspepsia was evaluated in five healthy volunteers and nine patients with dysmotility-like symptoms [2].
  • Single-dose versus six-day therapy with sulfamethizole for asymptomatic bacteriuria during pregnancy. A prospective randomised study [3].
  • METHODS: Gastric emptying in 14 patients with chronic hepatitis C was estimated by the sulfamethizole capsule method before and 1 and 2 weeks after the beginning of interferon-alpha (6 million U/day) therapy [4].
  • The results indicated that a sensitive E. coli population should be suppressed by sulphamethizole in urine for two-thirds of the time (with 1 g twice-daily) and by mecillinam in urine throughout the 24-h period (with 400 mg three times a day) [5].

High impact information on Sulphamethizole


Chemical compound and disease context of Sulphamethizole


Biological context of Sulphamethizole


Anatomical context of Sulphamethizole


Associations of Sulphamethizole with other chemical compounds


Gene context of Sulphamethizole

  • There was a slight but significant correlation between the ex-vivo effect (Delta log10 CFU/mL) and the log10 concentration/MIC ratio after exposure to sulphamethizole for 5 h (r2 = 0.27, p < 0.0001), and a significant correlation between the variables with mecillinam (r2 = 0.66, p < 0.0001) [5].

Analytical, diagnostic and therapeutic context of Sulphamethizole


  1. Adverse pregnancy outcome in users of sulfamethizole during pregnancy: a population-based observational study. Ratanajamit, C., Skriver, M.V., Nørgaard, M., Jepsen, P., Schønheyder, H.C., Sørensen, H.T. J. Antimicrob. Chemother. (2003) [Pubmed]
  2. Sulfamethizole capsules containing contrast medium for assessment of gastric emptying in functional dyspepsia patients. Suzuki, T., Yamamoto, Y., Abe, K., Hirano, M., Oka, H. Dig. Dis. Sci. (1999) [Pubmed]
  3. Single-dose versus six-day therapy with sulfamethizole for asymptomatic bacteriuria during pregnancy. A prospective randomised study. Olsen, L., Nielsen, I.K., Zachariassen, A., Sederberg-Olsen, J., Frimodt-Möller, N. Danish medical bulletin. (1989) [Pubmed]
  4. Delayed gastric emptying during interferon-alpha therapy in patients with chronic hepatitis C: relief by cisapride. Nishibayashi, H., Kanayama, S., Shinomura, Y., Kawata, S., Matsuzawa, Y. Scand. J. Gastroenterol. (1997) [Pubmed]
  5. Urinary concentrations and urine ex-vivo effect of mecillinam and sulphamethizole. Kerrn, M.B., Frimodt-Møller, N., Espersen, F. Clin. Microbiol. Infect. (2004) [Pubmed]
  6. Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Kerrn, M.B., Frimodt-Møller, N., Espersen, F. Antimicrob. Agents Chemother. (2003) [Pubmed]
  7. Susceptibility of Danish Escherichia coli strains isolated from urinary tract infections and bacteraemia, and distribution of sul genes conferring sulphonamide resistance. Kerrn, M.B., Klemmensen, T., Frimodt-Møller, N., Espersen, F. J. Antimicrob. Chemother. (2002) [Pubmed]
  8. Different gastric emptying of solid and liquid meals after pylorus-preserving pancreatoduodenectomy. Kobayashi, I., Miyachi, M., Kanai, M., Nagino, M., Kondo, S., Kamiya, J., Nakao, M., Hayakawa, N., Nimura, Y. The British journal of surgery. (1998) [Pubmed]
  9. Effects of nephrotoxic compounds on active uptake of drugs in isolated renal tubules in rabbits. Okumura, K., Yamakita, H., Kamiya, A., Hori, R. Biochem. Pharmacol. (1984) [Pubmed]
  10. Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Watanabe, H., Hastings, J.W. Biochim. Biophys. Acta (1990) [Pubmed]
  11. Bioavailability of sulfonamide suspensions I: Dissolution profiles of sulfamethizole using paddle method. Strum, J.D., Colaizzi, J.L., Goehl, T.J., Jaffe, J.M., Pitlick, W.H., Shah, V.P., Poust, R.I. Journal of pharmaceutical sciences. (1978) [Pubmed]
  12. Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments. Komatsu, K., Ito, K., Nakajima, Y., Kanamitsu, S., Imaoka, S., Funae, Y., Green, C.E., Tyson, C.A., Shimada, N., Sugiyama, Y. Drug Metab. Dispos. (2000) [Pubmed]
  13. Short-term versus continuous antimicrobial therapy for asymptomatic bacteriuria in pregnancy. Whalley, P.J., Cunningham, F.G. Obstetrics and gynecology. (1977) [Pubmed]
  14. Oxidation of sulfonamides, macrolides, and carbadox with free chlorine and monochloramine. Chamberlain, E., Adams, C. Water Res. (2006) [Pubmed]
  15. Kinetic studies on drug disposition in rabbits. II. Dose dependent pharmacokinetics of sulfamethizole. Katayama, K., Ohtani, H., Murai, A., Kakemi, M., Koizumi, T. J. Pharmacobio-dyn. (1990) [Pubmed]
  16. Sulphamethizole in urinary tract infections. Peddie, B.A., Little, P.J. J. Antimicrob. Chemother. (1979) [Pubmed]
  17. Sulfamethizole capsule method. A new method for assessing gastric emptying of solids. Asada, T., Murakami, M., Sako, Y., Fukushima, Y., Yonekura, Y., Konishi, J., Kita, T., Miyake, T., Asada, T. Dig. Dis. Sci. (1994) [Pubmed]
  18. Gastric emptying after pylorus-preserving gastrectomy in comparison with conventional subtotal gastrectomy for early gastric carcinoma. Imada, T., Rino, Y., Takahashi, M., Hatori, S., Tanaka, J., Shiozawa, M., Chin, C., Yamamoto, Y., Amano, T., Nakamura, K. Surgery today. (1998) [Pubmed]
  19. Nitrofurantoin, sulfamethizole and cephalexin urinary concentration in unequally functioning pyelonephritic kidneys. Sullivan, J.W., Bueschen, A.J., Schlegel, J.U. J. Urol. (1975) [Pubmed]
  20. Studies on drug-milk freeze-dried formulations. I: Bioavailability of sulfamethizole and dicumarol formulations. Macheras, P.E., Reppas, C.I. Journal of pharmaceutical sciences. (1986) [Pubmed]
  21. Binding capacities of human serum albumin monomer and dimer by continuous frontal affinity chromatography. Nakano, N.I., Shimamori, Y., Yamaguchi, S. J. Chromatogr. (1982) [Pubmed]
  22. Treatment of urinary tract infections with sulphonamide and/or trimethoprim. A preliminary report from a multipractice study. Mabeck, C.E., Vejlsgaard, R. Infection (1979) [Pubmed]
  23. Effects of erythromycin in chronic idiopathic intestinal pseudo-obstruction. Minami, T., Nishibayashi, H., Shinomura, Y., Matsuzawa, Y. J. Gastroenterol. (1996) [Pubmed]
  24. Sustained release of sulfamethizole from agar beads after oral administration to humans. Nakano, M., Kouketsu, M., Nakamura, Y., Juni, K. Chem. Pharm. Bull. (1980) [Pubmed]
  25. Effect of exercise on the serum level and urinary excretion of tetracycline, doxycycline and sulphamethizole. Ylitalo, P., Hinkka, H., Neuvonen, P.J. Eur. J. Clin. Pharmacol. (1977) [Pubmed]
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