Disease relevance of Sulphamethizole

• CONCLUSIONS: We found no increased risk of congenital malformation, stillbirth or pre-term birth, and no association between use of sulfamethizole late in pregnancy and risk of neonatal jaundice [1].
• The usefulness of sulfamethizole capsules containing contrast medium in gastric emptying tests for functional dyspepsia was evaluated in five healthy volunteers and nine patients with dysmotility-like symptoms [2].
• Single-dose versus six-day therapy with sulfamethizole for asymptomatic bacteriuria during pregnancy. A prospective randomised study [3].
• METHODS: Gastric emptying in 14 patients with chronic hepatitis C was estimated by the sulfamethizole capsule method before and 1 and 2 weeks after the beginning of interferon-alpha (6 million U/day) therapy [4].
• The results indicated that a sensitive E. coli population should be suppressed by sulphamethizole in urine for two-thirds of the time (with 1 g twice-daily) and by mecillinam in urine throughout the 24-h period (with 400 mg three times a day) [5].

High impact information on Sulphamethizole

• Infection with a sulII gene-positive strain (MIC, >2,048 micro g/ml) could not be treated with sulfamethizole, as no effect could be demonstrated in the urine, bladder, or kidneys [6].
• The case-control analysis included 3347 women who had a miscarriage, of whom 90 had taken sulfamethizole, and 22599 primiparous controls who had a live birth [1].
• In strains with sulfamethizole MICs > 2048 mg/L, 97% carried sulI, sulII or both genes, with sulII being the most common [7].
• Two pharmacological gastric-emptying tests were used: the acetaminophen test for liquid-phase emptying and the sulphamethizole capsule food test for solid-phase gastric emptying [8].
• The uptake of sulfonamides and phenolsulfonphthalein (PSP) was examined in vitro using isolated renal proximal tubule suspension, and the effects of nephrotoxic compounds on the uptake of sulfamethizole (SMZ) were studied [9].

Chemical compound and disease context of Sulphamethizole

• Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine [10].

Biological context of Sulphamethizole

• A comparative bioavailability study was performed using two commercially available, chemically equivalent brands of sulfamethizole suspension [11].
• About 4.8- and 1.6-fold increases in tolbutamide AUC were predicted by coadministration of sulfaphenazole and sulfamethizole, respectively, which agreed well with the reported increases in humans [12].
• In one group of 200 women short-term treatment with either nitrofurantoin or sulfamethizole was given for 14 days, and in another group of 100 women continuous therapy with one of these drugs was given for the remainder of gestation [13].
• The oxidation of 10 antibiotics-carbadox, erythromycin-H(2)O, roxithromycin, sulfadimethoxine, sulfamerazine, sulfamethazine, sulfamethizole, sulfamethoxazole, sulfathiozole, and tylosin during chlorination and monochloramination in laboratory and surface waters was investigated to identify kinetics and treatment effectiveness [14].
• Kinetic studies on drug disposition in rabbits. II. Dose dependent pharmacokinetics of sulfamethizole [15].

Anatomical context of Sulphamethizole

• Sulphamethizole in urinary tract infections [16].
• This method is based on the rapid absorption of sulfamethizole in the upper small intestine [17].
• In this study, we evaluated the difference in postoperative gastric remnant emptying following pylorus-preserving gastrectomy (PPG) and conventional subtotal gastrectomy (CDG) using sulfamethizole capsule food [18].

Associations of Sulphamethizole with other chemical compounds

• Nitrofurantoin, sulfamethizole and cephalexin peak urinary drug concentrations were studied in patients and non-human primates with unequally functioning pyelonephritic kidneys [19].
• Studies on drug-milk freeze-dried formulations. I: Bioavailability of sulfamethizole and dicumarol formulations [20].
• For salicylic acid, warfarin, phenylbutazone, mefenamic acid, sulphamethizole and sulphonylureas, the binding capacities of the monomer and dimer were compared by continuous frontal affinity chromatography [21].
• In a double-blind study 1194 patients with bacteriologically diagnosed urinary tract infection were randomly selected for treatment with either 1 g sulphamethizole twice daily, 200 mg trimethoprim twice daily, or 410 mg sulphadiazine plus 90 mg trimethoprim twice daily [22].
• Gastric emptying, measured by the sulfamethizole method; and intestinal transit, evaluated using radio-opaque markers, were markedly improved by treatment with erythromycin [23].

Gene context of Sulphamethizole

• There was a slight but significant correlation between the ex-vivo effect (Delta log10 CFU/mL) and the log10 concentration/MIC ratio after exposure to sulphamethizole for 5 h (r2 = 0.27, p < 0.0001), and a significant correlation between the variables with mecillinam (r2 = 0.66, p < 0.0001) [5].

Analytical, diagnostic and therapeutic context of Sulphamethizole

• Treatment with sulfamethizole resulted in a significant reduction in bacterial counts in all samples from a susceptible strain (MIC, 128 micro g/ml) and a resistant strain (MIC, 512 micro g/ml) [6].
• Adverse pregnancy outcome in users of sulfamethizole during pregnancy: a population-based observational study [1].
• METHODS: The association between use of sulfamethizole and adverse birth and neonatal outcome was investigated in a case-control and a cohort study in Denmark [1].
• Sustained release of sulfamethizole from agar beads after oral administration to humans [24].
• The serum level and urinary excretion of sulphamethizole, tetracycline and doxycycline were studied in healthy volunteers subjected to intensive exercise and bed rest in a cross-over trial [25].

References