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Chemical Compound Review

Deposul     4-amino-N-(2,6- dimethoxypyrimidin-4...

Synonyms: Diasulfa, Madribon, Madrigid, Madriqid, Madroxin, ...
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Disease relevance of Deposul


High impact information on Deposul


Chemical compound and disease context of Deposul


Biological context of Deposul


Anatomical context of Deposul


Associations of Deposul with other chemical compounds


Gene context of Deposul

  • Results showed that bilirubin exposure modulated both alpha and beta CaM kinase II subunit expression in selective neuronal populations, but sulfadimethoxine had no acute effect on enzyme immunoreactivity [29].
  • Using sulfadimethoxine as a prototype differences in displacement were found in all 3 sera [30].

Analytical, diagnostic and therapeutic context of Deposul


  1. Effects of hyperbilirubinaemia on glutathione S-transferase isoenzymes in cerebellar cortex of the Gunn rat. Johnson, J.A., Hayward, J.J., Kornguth, S.E., Siegel, F.L. Biochem. J. (1993) [Pubmed]
  2. Somatosensory and brainstem auditory evoked potentials in the Gunn rat model of acute bilirubin neurotoxicity. Shapiro, S.M. Pediatr. Res. (2002) [Pubmed]
  3. Biliverdin-induced brainstem auditory evoked potential abnormalities in the jaundiced Gunn rat. Rice, A.C., Shapiro, S.M. Brain Res. (2006) [Pubmed]
  4. Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH-dependent cell interaction, internalization and cytotoxicity in vitro. Na, K., Lee, E.S., Bae, Y.H. Journal of controlled release : official journal of the Controlled Release Society. (2003) [Pubmed]
  5. Sequential analysis of development of invasive thyroid follicular cell carcinomas in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation. Imai, T., Onose, J., Hasumura, M., Ueda, M., Takizawa, T., Hirose, M. Toxicologic pathology. (2004) [Pubmed]
  6. Postnatal development of somatosensory evoked potential in jaundiced Gunn rats and effects of sulfadimethoxine administration. Silver, S., Sohmer, H., Kapitulnik, J. Pediatr. Res. (1996) [Pubmed]
  7. Visual evoked potential abnormalities in jaundiced Gunn rats treated with sulfadimethoxine. Silver, S., Sohmer, H., Kapitulnik, J. Pediatr. Res. (1995) [Pubmed]
  8. Reversible brainstem auditory evoked potential abnormalities in jaundiced Gunn rats given sulfonamide. Shapiro, S.M. Pediatr. Res. (1993) [Pubmed]
  9. Blood-brain barrier permeability to bilirubin in the rat studied using intracarotid bolus injection and in situ brain perfusion techniques. Ives, N.K., Gardiner, R.M. Pediatr. Res. (1990) [Pubmed]
  10. Acute brainstem auditory evoked potential abnormalities in jaundiced Gunn rats given sulfonamide. Shapiro, S.M. Pediatr. Res. (1988) [Pubmed]
  11. Anticryptosporidial activity is associated with specific sulfonamides in immunosuppressed rats. Rehg, J.E. J. Parasitol. (1991) [Pubmed]
  12. Prevention of coccidiosis in domestic dogs and captive coyotes (Canis latrans) with sulfadimethoxine-ormetoprim combination. Dunbar, M.R., Foreyt, W.J. Am. J. Vet. Res. (1985) [Pubmed]
  13. Paradoxical effect of Tween 80 between the susceptibility to rifampicin and streptomycin and the susceptibility to ethambutol and sulfadimethoxine in the Mycobacterium avium-Mycobacterium intracellulare complex. Yamori, S., Tsukamura, M. Microbiol. Immunol. (1991) [Pubmed]
  14. Incompatibility of R plasmids derived from Salmonella and Escherichia coli strains isolated simultaneously from a bovine fecal sample. Ishiguro, N., Sato, G., Ichijo, S., Konishi, T. Am. J. Vet. Res. (1980) [Pubmed]
  15. Empyema of the guttural pouch (auditory tube diverticulum) in horses: 91 cases (1977-1997). Judy, C.E., Chaffin, M.K., Cohen, N.D. J. Am. Vet. Med. Assoc. (1999) [Pubmed]
  16. Effects of sulfadimethoxine on tissue distribution of (14C)bilirubin in the newborn and adult hyperbilirubinemic Gunn rate. Davis, D.R., Yeary, R.A. Pediatr. Res. (1975) [Pubmed]
  17. Disposition of sulfadimethoxine in cattle: inclusion of protein binding factors in a pharmacokinetic model. Bourne, D.W., Bialer, M., Dittert, L.W., Hayashi, M., Rudawsky, G., Koritz, G.D., Bevill, R.F. Journal of pharmaceutical sciences. (1981) [Pubmed]
  18. Differential effects of ketoprofen on the pharmacokinetics of sulphadimethoxine in fast and slow acetylator rabbits. Imamura, Y., Mori, H., Otagiri, M. J. Pharm. Pharmacol. (1990) [Pubmed]
  19. Sulfadimethoxine degradation kinetics in manure as affected by initial concentration, moisture, and temperature. Wang, Q.Q., Bradford, S.A., Zheng, W., Yates, S.R. J. Environ. Qual. (2006) [Pubmed]
  20. Effect of rat thyroid proliferative lesion development by intermittent treatment with sulfadimethoxine. Shimo, T., Mitsumori, K., Onodera, H., Takahashi, M., Ueno, Y., Katayama, J., Saito, A., Takahashi, M. Cancer Lett. (1995) [Pubmed]
  21. Activity of sulfadimethoxine against cryptosporidiosis in dairy calves. Fayer, R. J. Parasitol. (1992) [Pubmed]
  22. Oral bioavailability and disposition of sulphadimethoxine in lobster, Homarus americanus, following single and multiple dosing regimens. Barron, M.G., James, M.O. Xenobiotica (1994) [Pubmed]
  23. Tissue sulfonamide concentration and correlation in turkeys. Epstein, R.L., Ashworth, R.B. Am. J. Vet. Res. (1989) [Pubmed]
  24. Disposition of sulfadimethoxine in the lobster (Homarus americanus). James, M.O., Barron, M.G. Veterinary and human toxicology. (1988) [Pubmed]
  25. Simplified determining procedure for routine residue monitoring of sulphamethazine and sulphadimethoxine in milk. Furusawa, N. Journal of chromatography. A. (2000) [Pubmed]
  26. Matrix solid-phase dispersion extraction and high-performance liquid chromatographic determination of residual sulfonamides in chicken. Kishida, K., Furusawa, N. Journal of chromatography. A. (2001) [Pubmed]
  27. Kinetics of drug-drug interactions in sheep: tolbutamide and sulfadimethoxine. Thiessen, J.J., Rowland, M. Journal of pharmaceutical sciences. (1977) [Pubmed]
  28. Application of shielded column liquid chromatography for determination of sulfamonomethoxine, sulfadimethoxine, and their N4-acetyl metabolites in milk. Kishida, K., Furusawa, N. Journal of chromatography. A. (2004) [Pubmed]
  29. Expression of the alpha and beta subunits of Ca2+/calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development: a quantitative light microscopic analysis. Conlee, J.W., Shapiro, S.M., Churn, S.B. Acta Neuropathol. (2000) [Pubmed]
  30. Measurement of drug displacement of protein-bound bilirubin using gel filtration. Yeary, R.A., Wise, K.J., Davis, D.R. Archives internationales de pharmacodynamie et de thérapie. (1977) [Pubmed]
  31. Intramolecular isobaric fragmentation: a curiosity of accurate mass analysis of sulfadimethoxine in pond water. Thurman, E.M., Ferrer, I., Benotti, M., Heine, C.E. Anal. Chem. (2004) [Pubmed]
  32. Binding of thiopental to plasma proteins: effects on distribution in the brain and heart. Ghoneim, M.M., Pandya, H.B., Kelley, S.E., Fischer, L.J., Corry, R.J. Anesthesiology (1976) [Pubmed]
  33. Simultaneous high-performance liquid chromatographic determination of residual sulphamonomethoxine, sulphadimethoxine and their N4-acetyl metabolites in foods of animal origin. Furusawa, N., Mukai, T. Journal of chromatography. A. (1994) [Pubmed]
  34. Displacement of bilirubin from cord serum by sulphadimethoxine, amoxycillin, clavulanic acid in combination with either amoxycillin or ticarcillin, temocillin and cloxacillin. Davies, B.E. British journal of clinical pharmacology. (1985) [Pubmed]
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