Disease relevance of Deposul

• For example, the concentration of subunit 4 (Yb2) was increased 2.2-fold (compared with non-jaundiced controls) in Gunn rats injected with saline and 7.4-fold in rats injected with 100 mg of sulphadimethoxine/kg body weight [1].
• In 16 to 17-d-old jaundiced (jj) Gunn rats, serial BAEPs and SEPs were obtained up to 8 h after acute bilirubin toxicity. jjs were injected with 150 mg/kg sulfadimethoxine to displace bilirubin into brain tissue (n = 8); littermate controls were jjs given saline (n = 4) and nonjaundiced given sulfadimethoxine or saline (n = 7) [2].
• In summary, biliverdin administration in jaundiced Gunn rat pups produces BAEP abnormalities consistent with those observed in the sulfadimethoxine model and human newborn hyperbilirubinemia and resulted in increased plasma bilirubin levels that correlate with the degree of neurological dysfunction [3].
• The cytotoxicity of adriamycin (ADR)-loaded and pH-sensitive nanoparticles made of pullulan acetate (PA) and sulfonamide (sulfadimethoxine; SDM) (PA/SDM) conjugate to a breast tumor cell line (MCF-7) was investigated to test the feasibility of the nanoparticles in targeting acidic tumor extracellular pH (pH(e)) [4].
• Sequential analysis of development of invasive thyroid follicular cell carcinomas in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation [5].

High impact information on Deposul

• Postnatal development of somatosensory evoked potential in jaundiced Gunn rats and effects of sulfadimethoxine administration [6].
• Visual evoked potential abnormalities in jaundiced Gunn rats treated with sulfadimethoxine [7].
• Abnormal BAEP occur in jaundiced Gunn rats after injection of sulfadimethoxine (sulfa) 100 mg/kg intraperitoneally, which displaces bilirubin from blood albumin binding sites and promotes the net transfer of bilirubin into brain tissue [8].
• Blood-brain barrier permeability to albumin-bound and free bilirubin was determined using injectates/perfusates containing a molar excess of human serum albumin with or without the addition of the displacing agent sulphadimethoxine [9].
• Baseline BAEP recordings were performed in anesthetized animals; then either sulfadimethoxine or an equal volume of saline was injected into the peritoneum [10].

Chemical compound and disease context of Deposul

• Two of the 5 agents with prophylactic activity, sulfadimethoxine and sulfamethazine, were effective also against an established infection, indicating that some sulfonamides may have therapeutic value in immunosuppressed patients with cryptosporidiosis [11].
• In experiment 1, daily treatment for 13 to 23 days with a combination of 27.5 mg of sulfadimethoxine/kg of body weight (BW) and 5.5 mg of ormetoprim/kg of BW admixed to the feed resulted in no significant (P greater than 0.05) difference in fecal oocyst counts between treated and nontreated groups of dogs or coyotes [12].
• Paradoxical effect of Tween 80 between the susceptibility to rifampicin and streptomycin and the susceptibility to ethambutol and sulfadimethoxine in the Mycobacterium avium-Mycobacterium intracellulare complex [13].
• Thermosensitive R plasmids conferring sextuple drug (ampicillin, chloramphenicol, kanamycin, streptomycin, sulfadimethoxine, and tetracycline) have not been reported in Japan. Genetic relationship of R plasmids derived from the multiresistant strains of Salmonella and E coli was discussed on the basis of incompatibility properties of R plasmids [14].
• Streptococcus equi was isolated from the guttural pouch in 14 of 44 horses; for Streptococcus spp, in vitro resistance to sulfadimethoxine and trimethoprim-sulfamethoxazole was detected [15].

Biological context of Deposul

• Effects of sulfadimethoxine on tissue distribution of (14C)bilirubin in the newborn and adult hyperbilirubinemic Gunn rate [16].
• Disposition of sulfadimethoxine in cattle: inclusion of protein binding factors in a pharmacokinetic model [17].
• Brainstem auditory evoked potential (BAEP) abnormalities occur in jaundiced Gunn rats given sulfadimethoxine to displace bilirubin bound to serum albumin, releasing it into the tissues [3].
• Differential effects of ketoprofen on the pharmacokinetics of sulphadimethoxine in fast and slow acetylator rabbits [18].
• Sulfadimethoxine degradation kinetics in manure as affected by initial concentration, moisture, and temperature [19].

Anatomical context of Deposul

• Effect of rat thyroid proliferative lesion development by intermittent treatment with sulfadimethoxine [20].
• Of 13 neonatal calves inoculated orally with 1.5 x 10(6) oocysts of Cryptosporidium parvum, 7 in group A were fed 5-g boluses of sulfadimethoxine for 21 consecutive days beginning 1 day before infection, and 6 calves in group B were untreated controls [21].
• The low bioavailability at the high dose probably resulted from poor absorption due to the limited solubility of sulphadimethoxine at the low pH of the lobster gastrointestinal tract [22].
• Nineteen hen turkeys (10 to 12 kg each) were used in a feeding study to determine sulfadimethoxine and sulfaquinoxaline concentrations in blood serum, liver, and skeletal muscle, as well as the respective ratios at selected withdrawal intervals [23].
• Elimination of parent sulfadimethoxine from hemolymph was very slow compared with elimination of the drug from blood of vertebrate species; the beta phase half-life was 77 hr in lobster as opposed to 7-40 hr in several vertebrate species [24].

Associations of Deposul with other chemical compounds

• The bilirubin content of brain tissue from both age groups was significantly higher after sulfadimethoxine treatment [16].
• A simplified determining/identifying method for residual sulphamethazine (SMZ) and sulphadimethoxine (SDM) in milk by using a high-performance liquid chromatography (HPLC) with a photo-diode array detector was presented [25].
• Simultaneous determination of the six sulfonamides (SAs) sulfadiazine, sulfadimidine, sulfamonomethoxine, sulfamethoxazole, sulfadimethoxine and sulfaquinoxaline in chicken using matrix solid-phase dispersion (MSPD) with neutral aluminium oxide as an MSPD sorbent and high-performance liquid chromatography (HPLC) is presented [26].
• Transient changes in tolbutamide's unbound and total plasma concentrations were noted after acute intravenous administration of sulfadimethoxine to sheep receiving a constant intravenous infusion of tolbutamide [27].
• Application of shielded column liquid chromatography for determination of sulfamonomethoxine, sulfadimethoxine, and their N4-acetyl metabolites in milk [28].

Gene context of Deposul

• Results showed that bilirubin exposure modulated both alpha and beta CaM kinase II subunit expression in selective neuronal populations, but sulfadimethoxine had no acute effect on enzyme immunoreactivity [29].
• Using sulfadimethoxine as a prototype differences in displacement were found in all 3 sera [30].

Analytical, diagnostic and therapeutic context of Deposul

• Liquid chromatography with time-of-flight mass spectrometry (TOF-MS) and quadrupole-time-of-flight (Q-TOF) mass spectrometry/mass spectrometry (MS/MS) were used for the accurate mass analysis of sulfadimethoxine in pond water of a fish hatchery [31].
• These studies show that neurophysiologic abnormalities occur as early as 2 h after intraperitoneal injection of sulfadimethoxine, and are reversible with appropriate therapy [10].
• Thiopental-14C (30 mg and 10 muCi/kg) was injected intravenously into rats 36-48 hours following bilateral nephrectomy and one minute after pretreatment with sulfadimethoxine (30 mg/kg, iv) [32].
• A rapid and sensitive method for the determination of residual sulphamonomethoxine, sulphadimethoxine and their N4-acetyl metabolites in beef, pork, chicken and eggs by high-performance liquid chromatography (HPLC) was developed [33].
• The displacement of bilirubin from its binding sites in cord serum by sulphadimethoxine and various penicillins was studied using Sephadex gel filtration [34].

References