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Chemical Compound Review

AC1NUOTS     (2S)-6-amino-2-[[2-[[(2S)-2- [[(2S)-2...

Synonyms: AG-H-53642, GHRP-6 Acetate, SureCN3047866, AC-6940, SKF-110679, ...
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Disease relevance of Growth hormone releasing peptide


Psychiatry related information on Growth hormone releasing peptide


High impact information on Growth hormone releasing peptide


Biological context of Growth hormone releasing peptide


Anatomical context of Growth hormone releasing peptide


Associations of Growth hormone releasing peptide with other chemical compounds


Gene context of Growth hormone releasing peptide

  • Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action [26].
  • This hypothesis was further explored by investigating the effects of continuous i.v. infusion of GHRH, GHRP, TRH and their combinations for several days [27].
  • In the rat, the synthetic GH secretagogue GH-releasing peptide (GHRP-6) acts centrally to activate a subpopulation of arcuate neurones as reflected by increased electrical activation and by the detection of Fos protein in cell nuclei [28].
  • In the present study, the possible somnogenic effects induced under similar conditions by GH-releasing peptide (GHRP) were investigated in seven young healthy men [29].
  • Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide (GHRP-6, a ligand for endogenous GH secretagogue receptors) were compared between 3-week-old (milk-fed) and 12-week-old (concentrate and hay-fed) calves [30].

Analytical, diagnostic and therapeutic context of Growth hormone releasing peptide


  1. Enhanced GH responses to combined administration of GHRP and GHRH in patients with acromegaly. Hanew, K., Utsumi, A., Sugawara, A., Shimizu, Y., Abe, K. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  2. Growth hormone-releasing peptide can improve left ventricular dysfunction and attenuate dilation in dilated cardiomyopathic hamsters. Iwase, M., Kanazawa, H., Kato, Y., Nishizawa, T., Somura, F., Ishiki, R., Nagata, K., Hashimoto, K., Takagi, K., Izawa, H., Yokota, M. Cardiovasc. Res. (2004) [Pubmed]
  3. Growth hormone-releasing hexapeptide (GHRP-6) increases intracellular calcium concentrations in cultured cells from human pituitary adenomas of different types. Lania, A., Ballaré, E., Corbetta, S., Filopanti, M., Persani, L., Spada, A. Eur. J. Endocrinol. (1998) [Pubmed]
  4. Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism. Pimentel-Filho, F.R., Ramos-Dias, J.C., Ninno, F.B., Façanha, C.F., Liberman, B., Lengyel, A.M. Clin. Endocrinol. (Oxf) (1997) [Pubmed]
  5. GH-releasing peptide (GHRP-6)-induced ACTH release in patients with addison's disease: effect of glucocorticoid withdrawal. Martins, M.R., Pinto, A.C., Brunner, E., Silva, M.R., Lengyel, A.M. J. Endocrinol. Invest. (2003) [Pubmed]
  6. Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa. Giusti, M., Foppiani, L., Ponzani, P., Cuttica, C.M., Falivene, M.R., Valenti, S. J. Endocrinol. Invest. (1997) [Pubmed]
  7. High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist. Holst, B., Cygankiewicz, A., Jensen, T.H., Ankersen, M., Schwartz, T.W. Mol. Endocrinol. (2003) [Pubmed]
  8. Complementary secretagogue pairs unmask prominent gender-related contrasts in mechanisms of growth hormone pulse renewal in young adults. Soares-Welch, C., Farhy, L., Mielke, K.L., Mahmud, F.H., Miles, J.M., Bowers, C.Y., Veldhuis, J.D. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  9. Reactivation of pituitary hormone release and metabolic improvement by infusion of growth hormone-releasing peptide and thyrotropin-releasing hormone in patients with protracted critical illness. Van den Berghe, G., Wouters, P., Weekers, F., Mohan, S., Baxter, R.C., Veldhuis, J.D., Bowers, C.Y., Bouillon, R. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  10. Human fetal pituitary expresses functional growth hormone-releasing peptide receptors. Shimon, I., Yan, X., Melmed, S. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  11. Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study. Massoud, A.F., Hindmarsh, P.C., Brook, C.G. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  12. Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure. Nagaya, N., Miyatake, K., Uematsu, M., Oya, H., Shimizu, W., Hosoda, H., Kojima, M., Nakanishi, N., Mori, H., Kangawa, K. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  13. Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites. Codd, E.E., Shu, A.Y., Walker, R.F. Neuropharmacology (1989) [Pubmed]
  14. Growth hormone-releasing hexapeptide is a potent stimulator of growth hormone gene expression and release in the growth hormone-releasing hormone-deprived infant rat. Locatelli, V., Grilli, R., Torsello, A., Cella, S.G., Wehrenberg, W.B., Müller, E.E. Pediatr. Res. (1994) [Pubmed]
  15. Disposition of growth hormone-releasing peptide (SK&F 110679) in rat and dog following intravenous or subcutaneous administration. Davis, C.B., Crysler, C.S., Boppana, V.K., Fong, K.L., Joseph, G.L., Urbanski, J.J., Macia, R.A., Rhodes, G.R. Drug Metab. Dispos. (1994) [Pubmed]
  16. Molecular cloning and gene expression of growth hormone-releasing peptide receptor in rat tissues. Yokote, R., Sato, M., Matsubara, S., Ohye, H., Niimi, M., Murao, K., Takahara, J. Peptides (1998) [Pubmed]
  17. Mechanisms of action of a second generation growth hormone-releasing peptide (Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2) in rat anterior pituitary cells. Akman, M.S., Girard, M., O'Brien, L.F., Ho, A.K., Chik, C.L. Endocrinology (1993) [Pubmed]
  18. Retrogradely labelled neurosecretory neurones of the rat hypothalamic arcuate nucleus express Fos protein following systemic injection of GH-releasing peptide-6. Dickson, S.L., Doutrelant-Viltart, O., Dyball, R.E., Leng, G. J. Endocrinol. (1996) [Pubmed]
  19. Six-week treatment with hexarelin in young dogs: evaluation of the GH responsiveness to acute hexarelin or GHRH administration, and of the orexigenic effect of hexarelin. Rigamonti, A.E., Cella, S.G., Marazzi, N., Müller, E.E. Eur. J. Endocrinol. (1999) [Pubmed]
  20. Growth hormone-releasing peptide (GHRP) binding to porcine anterior pituitary and hypothalamic membranes. Veeraragavan, K., Sethumadhavan, K., Bowers, C.Y. Life Sci. (1992) [Pubmed]
  21. Role of selected endogenous peptides in growth hormone-releasing hexapeptide activity: analysis of growth hormone-releasing hormone, thyroid hormone-releasing hormone, and gonadotropin-releasing hormone. Bercu, B.B., Yang, S.W., Masuda, R., Walker, R.F. Endocrinology (1992) [Pubmed]
  22. Growth hormone release induced by growth hormone-releasing hexapeptide is not mediated by thyrotropin-releasing hormone in neonatal rats. Kacsóh, B., Kacsóh, G., Guzzardo, M.B., Black, A.C., Bisat, T. Pediatr. Res. (1997) [Pubmed]
  23. GH and cortisol rebound rise during and following a somatostatin infusion: studies in dogs with the use of a GH-releasing peptide. Rigamonti, A.E., Bonomo, S.M., Cella, S.G., Müller, E.E. J. Endocrinol. (2002) [Pubmed]
  24. Intranasal administration of the GHRP hexarelin accelerates growth in short children. Laron, Z., Frenkel, J., Deghenghi, R., Anin, S., Klinger, B., Silbergeld, A. Clin. Endocrinol. (Oxf) (1995) [Pubmed]
  25. Chemical approaches to improve the oral bioavailability of peptidergic molecules. Samanen, J., Wilson, G., Smith, P.L., Lee, C.P., Bondinell, W., Ku, T., Rhodes, G., Nichols, A. J. Pharm. Pharmacol. (1996) [Pubmed]
  26. Central effects of growth hormone-releasing hexapeptide (GHRP-6) on growth hormone release are inhibited by central somatostatin action. Fairhall, K.M., Mynett, A., Robinson, I.C. J. Endocrinol. (1995) [Pubmed]
  27. Novel insights into the neuroendocrinology of critical illness. Van den Berghe, G. Eur. J. Endocrinol. (2000) [Pubmed]
  28. GH-deficient dw/dw rats and lit/lit mice show increased Fos expression in the hypothalamic arcuate nucleus following systemic injection of GH-releasing peptide-6. Dickson, S.L., Doutrelant-Viltart, O., Leng, G. J. Endocrinol. (1995) [Pubmed]
  29. Evidence against a role for the growth hormone-releasing peptide axis in human slow-wave sleep regulation. Moreno-Reyes, R., Kerkhofs, M., L'Hermite-Balériaux, M., Thorner, M.O., Van Cauter, E., Copinschi, G. Am. J. Physiol. (1998) [Pubmed]
  30. Postprandial changes in plasma GH and insulin concentrations, and responses to stimulation with GH-releasing hormone (GHRH) and GHRP-6 in calves around weaning. Katoh, K., Furukawa, G., Kitade, K., Katsumata, N., Kobayashi, Y., Obara, Y. J. Endocrinol. (2004) [Pubmed]
  31. MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism. Murphy, M.G., Plunkett, L.M., Gertz, B.J., He, W., Wittreich, J., Polvino, W.M., Clemmons, D.R. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  32. Combined evaluation of resting IGF-I, N-terminal propeptide of type III procollagen (PIIINP) and C-terminal cross-linked telopeptide of type I collagen (ICTP) levels might be useful for detecting inappropriate GH administration in athletes: a preliminary report. Sartorio, A., Agosti, F., Marazzi, N., Maffiuletti, N.A., Cella, S.G., Rigamonti, A.E., Guidetti, L., Di Luigi, L., Muller, E.E. Clin. Endocrinol. (Oxf) (2004) [Pubmed]
  33. Abuse of recombinant human growth hormone: studies in two different dog models. Rigamonti, A.E., Scanniffio, D., Bonomo, S.M., Cella, S.G., Sartorio, A., Müller, E.E. Neuroendocrinology (2004) [Pubmed]
  34. Growth hormone-releasing effect of oral growth hormone-releasing peptide 6 (GHRP-6) administration in children with short stature. Bellone, J., Ghizzoni, L., Aimaretti, G., Volta, C., Boghen, M.F., Bernasconi, S., Ghigo, E. Eur. J. Endocrinol. (1995) [Pubmed]
  35. Determination of growth hormone-releasing hexapeptide by reversed-phase high-performance liquid chromatography with electrochemical detection. Choi, S.J., Lee, H.Y., Kim, S.B., Kim, J.H., Lee, S.S., Yoo, S.D., Lee, K.C., Lee, H.S. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
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