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Gene Review

Guca2b  -  guanylate cyclase activator 2b (retina)

Mus musculus

Synonyms: AV066530, Gcap2, Guanylate cyclase activator 2B, Ugn, uroguanylin
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Disease relevance of Guca2b


Psychiatry related information on Guca2b


High impact information on Guca2b


Chemical compound and disease context of Guca2b


Biological context of Guca2b


Anatomical context of Guca2b


Associations of Guca2b with chemical compounds


Physical interactions of Guca2b

  • Thus, uroguanylin and guanylin seem to serve as intestinal and renal natriuretic peptide-hormones influencing salt and water transport in the kidney through GC-C dependent and independent pathways [2].

Regulatory relationships of Guca2b

  • Guanylin and uroguanylin are peptides that activate guanylyl cyclase C (GC-C) receptors in the intestine and kidney, which causes an increase in the excretion of salt and water [6].

Other interactions of Guca2b


Analytical, diagnostic and therapeutic context of Guca2b

  • METHODS: Effects of guanylin and uroguanylin on principal cells of human cortical collecting ducts (CCD) isolated from kidneys after tumor nephrectomy were investigated [5].
  • Immunohistochemistry, using a uroguanylin peptide-specific, affinity-purified antibody, demonstrated that immunoreactive uroguanylin peptide was localized to the same cells but that the staining was stronger in zinc-deficient rats [14].
  • Control, but not CF, mice produced a significant increase in duodenal bicarbonate secretion after perfusion with forskolin, uroguanylin, or 8-Br-cGMP [12].
  • Experiments using pH-stat titration revealed that uroguanylin stimulates serosal-to-luminal HCO3- secretion (Js-->lHCO3-) together with a larger increase in Isc [13].


  1. Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. Carrithers, S.L., Ott, C.E., Hill, M.J., Johnson, B.R., Cai, W., Chang, J.J., Shah, R.G., Sun, C., Mann, E.A., Fonteles, M.C., Forte, L.R., Jackson, B.A., Giannella, R.A., Greenberg, R.N. Kidney Int. (2004) [Pubmed]
  2. Renal effects of uroguanylin and guanylin in vivo. Carrithers, S.L., Hill, M.J., Johnson, B.R., O'Hara, S.M., Jackson, B.A., Ott, C.E., Lorenz, J., Mann, E.A., Giannella, R.A., Forte, L.R., Greenberg, R.N. Braz. J. Med. Biol. Res. (1999) [Pubmed]
  3. Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells. Sindiće, A., Başoglu, C., Cerçi, A., Hirsch, J.R., Potthast, R., Kuhn, M., Ghanekar, Y., Visweswariah, S.S., Schlatter, E. J. Biol. Chem. (2002) [Pubmed]
  4. Cellular effects of guanylin and uroguanylin. Sindić, A., Schlatter, E. J. Am. Soc. Nephrol. (2006) [Pubmed]
  5. Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts. Sindić, A., Hirsch, J.R., Velic, A., Piechota, H., Schlatter, E. Kidney Int. (2005) [Pubmed]
  6. Cloning and mRNA expression of guanylin, uroguanylin, and guanylyl cyclase C in the Spinifex hopping mouse, Notomys alexis. Donald, J.A., Bartolo, R.C. Gen. Comp. Endocrinol. (2003) [Pubmed]
  7. Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. Lorenz, J.N., Nieman, M., Sabo, J., Sanford, L.P., Hawkins, J.A., Elitsur, N., Gawenis, L.R., Clarke, L.L., Cohen, M.B. J. Clin. Invest. (2003) [Pubmed]
  8. Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP. Shailubhai, K., Yu, H.H., Karunanandaa, K., Wang, J.Y., Eber, S.L., Wang, Y., Joo, N.S., Kim, H.D., Miedema, B.W., Abbas, S.Z., Boddupalli, S.S., Currie, M.G., Forte, L.R. Cancer Res. (2000) [Pubmed]
  9. Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. Steinbrecher, K.A., Mann, E.A., Giannella, R.A., Cohen, M.B. Gastroenterology (2001) [Pubmed]
  10. Uroguanylin and guanylin: distinct but overlapping patterns of messenger RNA expression in mouse intestine. Whitaker, T.L., Witte, D.P., Scott, M.C., Cohen, M.B. Gastroenterology (1997) [Pubmed]
  11. Guanylin peptides: cyclic GMP signaling mechanisms. Forte, L.R., Freeman, R.H., Krause, W.J., London, R.M. Braz. J. Med. Biol. Res. (1999) [Pubmed]
  12. Heat-stable enterotoxin of Escherichia coli stimulates a non-CFTR-mediated duodenal bicarbonate secretory pathway. Sellers, Z.M., Childs, D., Chow, J.Y., Smith, A.J., Hogan, D.L., Isenberg, J.I., Dong, H., Barrett, K.E., Pratha, V.S. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  13. Regulation of intestinal Cl- and HCO3-secretion by uroguanylin. Joo, N.S., London, R.M., Kim, H.D., Forte, L.R., Clarke, L.L. Am. J. Physiol. (1998) [Pubmed]
  14. Dietary zinc deficiency increases uroguanylin accumulation in rat kidney. Cui, L., Blanchard, R.K., Cousins, R.J. Kidney Int. (2001) [Pubmed]
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