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Chemical Compound Review

Guanylin     (4S)-4-[[(2S)-2-[[(2S,3R)-2- [[(2S)-3...

Synonyms: AC1NUR9A, 140653-38-9, Guanylin (rat reduced)
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Disease relevance of Guanylin


Psychiatry related information on Guanylin


High impact information on Guanylin


Chemical compound and disease context of Guanylin


Biological context of Guanylin


Anatomical context of Guanylin


Associations of Guanylin with other chemical compounds


Gene context of Guanylin

  • Whole-cell patch-clamp recordings in the Clara cell line H441 revealed that guanylin activates CFTR Cl(-) conductance via the cGMP but not the cAMP-signaling pathway [24].
  • BACKGROUND: Guanylin (GN) and uroguanylin (UGN) are intestinally derived peptide hormones that are similar in structure and activity to the diarrhea-causing Escherichia coli heat-stable enterotoxins (STa) [25].
  • However, in the majority of these studies membrane-bound guanylate cyclase was investigated following stimulation with natriuretic peptides, guanylin, or the Ca2+ sensor proteins, S100B and S100A1 [26].
  • In intestinal tumors, GC-C expression is maintained while guanylin and uroguanylin expression is lost, suggesting a role for GC-C activation in tumor formation or growth [27].
  • Guanylin (PNTCEICAYAACTGC) is a peptide recently isolated from the intestine, the actions of which appear to be mimicked by bacterial heat-stable enterotoxins (Currie, M. G., Fok, K. F., Kato, J., Moore, R. J., Hamra, F. K., Duffin, K. L., and Smith, C. E. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 947-951) [28].

Analytical, diagnostic and therapeutic context of Guanylin


  1. Regulation of taurine transport by Escherichia coli heat-stable enterotoxin and guanylin in human intestinal cell lines. Brandsch, M., Ramamoorthy, S., Marczin, N., Catravas, J.D., Leibach, J.W., Ganapathy, V., Leibach, F.H. J. Clin. Invest. (1995) [Pubmed]
  2. Guanylin strongly stimulates rat duodenal HCO3- secretion: proposed mechanism and comparison with other secretagogues. Guba, M., Kuhn, M., Forssmann, W.G., Classen, M., Gregor, M., Seidler, U. Gastroenterology (1996) [Pubmed]
  3. Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation. Steinbrecher, K.A., Wowk, S.A., Rudolph, J.A., Witte, D.P., Cohen, M.B. Am. J. Pathol. (2002) [Pubmed]
  4. Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target membrane domains. Kulaksiz, H., Rehberg, E., Stremmel, W., Cetin, Y. Am. J. Pathol. (2002) [Pubmed]
  5. Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics. Forte, L.R. Pharmacol. Ther. (2004) [Pubmed]
  6. Cloning and mRNA expression of guanylin, uroguanylin, and guanylyl cyclase C in the Spinifex hopping mouse, Notomys alexis. Donald, J.A., Bartolo, R.C. Gen. Comp. Endocrinol. (2003) [Pubmed]
  7. The molecular basis of hypertension. Garbers, D.L., Dubois, S.K. Annu. Rev. Biochem. (1999) [Pubmed]
  8. Guanylin stimulation of Cl- secretion in human intestinal T84 cells via cyclic guanosine monophosphate. Forte, L.R., Eber, S.L., Turner, J.T., Freeman, R.H., Fok, K.F., Currie, M.G. J. Clin. Invest. (1993) [Pubmed]
  9. Guanylin regulates chloride secretion in the human gallbladder via the bile fluid. Kulaksiz, H., Schlenker, T., Rost, D., Stiehl, A., Volkmann, M., Lehnert, T., Cetin, Y., Stremmel, W. Gastroenterology (2004) [Pubmed]
  10. Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. Steinbrecher, K.A., Mann, E.A., Giannella, R.A., Cohen, M.B. Gastroenterology (2001) [Pubmed]
  11. Receptors for Escherichia coli heat stable enterotoxin in human intestine and in a human intestinal cell line (Caco-2). Cohen, M.B., Jensen, N.J., Hawkins, J.A., Mann, E.A., Thompson, M.R., Lentze, M.J., Giannella, R.A. J. Cell. Physiol. (1993) [Pubmed]
  12. Chloride secretion in response to guanylin in colonic epithelial from normal and transgenic cystic fibrosis mice. Cuthbert, A.W., Hickman, M.E., MacVinish, L.J., Evans, M.J., Colledge, W.H., Ratcliff, R., Seale, P.W., Humphrey, P.P. Br. J. Pharmacol. (1994) [Pubmed]
  13. A role for guanylate cyclase C in acid-stimulated duodenal mucosal bicarbonate secretion. Rao, S.P., Sellers, Z., Crombie, D.L., Hogan, D.L., Mann, E.A., Childs, D., Keely, S., Sheil-Puopolo, M., Giannella, R.A., Barrett, K.E., Isenberg, J.I., Pratha, V.S. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  14. Enzyme-ultracytochemical study of adenylate and guanylate cyclases in normal and pathologic human nasal mucosa. Rambotti, M.G., Altissimi, G., Spreca, A. European journal of histochemistry : EJH. (2004) [Pubmed]
  15. Guanylin: an endogenous activator of intestinal guanylate cyclase. Currie, M.G., Fok, K.F., Kato, J., Moore, R.J., Hamra, F.K., Duffin, K.L., Smith, C.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  16. Precursor structure, expression, and tissue distribution of human guanylin. de Sauvage, F.J., Keshav, S., Kuang, W.J., Gillett, N., Henzel, W., Goeddel, D.V. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  17. Analysis of the human guanylin gene and the processing and cellular localization of the peptide. Hill, O., Kuhn, M., Zucht, H.D., Cetin, Y., Kulaksiz, H., Adermann, K., Klock, G., Rechkemmer, G., Forssmann, W.G., Mägert, H.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. Uroguanylin and guanylin: distinct but overlapping patterns of messenger RNA expression in mouse intestine. Whitaker, T.L., Witte, D.P., Scott, M.C., Cohen, M.B. Gastroenterology (1997) [Pubmed]
  19. Guanylin, an endogenous ligand for C-type guanylate cyclase, is produced by goblet cells in the rat intestine. Li, Z., Taylor-Blake, B., Light, A.R., Goy, M.F. Gastroenterology (1995) [Pubmed]
  20. Uroguanylin is expressed by enterochromaffin cells in the rat gastrointestinal tract. Perkins, A., Goy, M.F., Li, Z. Gastroenterology (1997) [Pubmed]
  21. Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity. Hamra, F.K., Eber, S.L., Chin, D.T., Currie, M.G., Forte, L.R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  22. Segmental differences in the effects of guanylin and Escherichia coli heat-stable enterotoxin on Cl- secretion in human gut. Kuhn, M., Adermann, K., Jähne, J., Forssmann, W.G., Rechkemmer, G. J. Physiol. (Lond.) (1994) [Pubmed]
  23. Molecular and biochemical characterization of a CNP-sensitive guanylyl cyclase in bovine tracheal smooth muscle. Borges, A., de Villarroel, S.S., Winand, N.J., de Bécemberg, I.L., Alfonzo, M.J., de Alfonzo, R.G. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  24. Clara cell impact in air-side activation of CFTR in small pulmonary airways. Kulaksiz, H., Schmid, A., Hönscheid, M., Ramaswamy, A., Cetin, Y. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. Carrithers, S.L., Ott, C.E., Hill, M.J., Johnson, B.R., Cai, W., Chang, J.J., Shah, R.G., Sun, C., Mann, E.A., Fonteles, M.C., Forte, L.R., Jackson, B.A., Giannella, R.A., Greenberg, R.N. Kidney Int. (2004) [Pubmed]
  26. Ultracytochemistry as a tool for the study of the cellular and subcellular localization of membrane-bound guanylate cyclase (GC) activity. Applicability to both receptor-activated and receptor-independent GC activity. Rambotti, M.G., Spreca, A., Giambanco, I., Sorci, G., Donato, R. Mol. Cell. Biochem. (2002) [Pubmed]
  27. Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model. Mann, E.A., Steinbrecher, K.A., Stroup, C., Witte, D.P., Cohen, M.B., Giannella, R.A. Int. J. Cancer (2005) [Pubmed]
  28. Cloning and expression of guanylin. Its existence in various mammalian tissues. Schulz, S., Chrisman, T.D., Garbers, D.L. J. Biol. Chem. (1992) [Pubmed]
  29. Low salt intake down-regulates the guanylin signaling pathway in rat distal colon. Li, Z., Knowles, J.W., Goyeau, D., Prabhakar, S., Short, D.B., Perkins, A.G., Goy, M.F. Gastroenterology (1996) [Pubmed]
  30. Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide. Cetin, Y., Kuhn, M., Kulaksiz, H., Adermann, K., Bargsten, G., Grube, D., Forssmann, W.G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
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