Disease relevance of SK 591

• Effects of vitamin B-6 deficiency and 4'- deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat [1].

High impact information on SK 591

• The pyridoxal kinase of blacks was indistinguishable from that of whites with respect to heat stability, chromatographic mobility on microgranular diethylaminoethyl cellulose, Michaelis-Menten constant for pyridoxine, and susceptibility to inhibition by 4-deoxypyridoxine [2].
• Moreover, the S1P lyase inhibitor 4-deoxypyridoxine induced the cellular accumulation of S1P but did not affect DNA synthesis [3].
• The vitamin B-6 antimetabolite 4-deoxypyridoxine, when injected into 13-day chick embryos, has the effect of increasing the amount of collagen solubilized from the leg bones by buffered saline solutions, 24 h after the injection [4].
• The injection of 5 mg of beta-aminopropionitrile causes the lysyl oxidase activity to fall to 61% of that of saline-injected controls; after treatment with 4-deoxypyridoxine, the activity is 74% of the control value [4].
• Attempts were therefore made to induce atherosclerosis in Macaca radiata, maintained on a high-protein, high-methionine and high-fat diet by inducing pyridoxine deficiency with deoxypyridoxine [5].

Biological context of SK 591

• Agglutination titre and respiratory burst activity were significantly higher in abalone fed diets supplemented with 40 mg PN kg(-1) than those fed the PN-free diet or the one with 4-deoxypyridoxine (P < 0.05) [6].
• DL-alpha-difluoromethylornithine (DFMO), 4-deoxypyridoxine (4-DOP), and methylglyoxal bis (guanylhydrazone) (MGBG) were tested as inhibitors of acute skin graft rejection [7].

Anatomical context of SK 591

• The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo [4].
• Lysyl oxidase, the cross-linking enzyme, was measured in extracts made from the epiphysial cartilages of embryos 24 h after the injection of either 4-deoxypyridoxine or beta-aminopropionitrile [4].
• Only deoxypyridoxine was effective in increasing c-fos mRNA and c-fos protein expression in nerve cells [8].
• We studied the levels of MCP-1 and MIP-2 in diaphragmatic and intercostal muscle tissue and serum in Trichinella spiralis infected mice treated and not treated with 4-deoxypyridoxine, a potent Vit [9].
• Titration studies of deoxypyridoxine showed the direct relation between the concentration of deoxypyridoxine and the degree of DNA synthesis' inhibition with subsequent lymphocyte proliferation [10].

Associations of SK 591 with other chemical compounds

• Metaphosphoric acid tissue extracts with deoxypyridoxine as an internal standard were injected into the HPLC system with a binary gradient elution at a flow-rate of 1.2 ml/min [11].
• Vitamin B6-deficient diet plus 4-deoxypyridoxine (4-DPD) reduces the inflammatory response induced by T. spiralis in diaphragm, masseter and heart muscle tissue of mice [12].
• Muscimol, baclofen and progabide reduced the disappearance rate of GABA in the substantia nigra following inhibition of the glutamate decarboxylase by 4-deoxypyridoxine [13].
• Effect of combination of deoxypyridoxine with known anti-proliferative or immunosuppressive agents on lymphocyte serine hydroxymethyltransferase [14].

Gene context of SK 591

• MCP-1 and MIP-2 response in Trichinella spiralis infected mice treated with 4-deoxypyridoxine (4-DPD) [9].
• Generation of TNF alpha, IFN gamma, IL-6, IL-4 and IL-10 in mouse serum from trichinellosis: effect of the anti-inflammatory compound 4-deoxypyridoxine (4-DPD) [15].
• Both pyridoxine and 4-desoxypyridoxine caused a progressively increasing inhibition of the response to renin, which was totally suppressed after 24 days of treatment [16].
• The NADPH oxidase activity remained unchanged following deoxypyridoxine treatment [17].
• The effect of phytohaemagglutinin or concanavalin A on the production of interleukin-1b, interleukin-2 and interleukin-2 receptors is profoundly affected by deoxypyridoxine [18].

Analytical, diagnostic and therapeutic context of SK 591

• No differences were found in organ size between the -B6 and both control groups indicating that short-term deprivation and deoxypyridoxine did not affect organ size [19].
• The addition of deoxypyridoxine simultaneously with or few hours prior to initiation of cell cultures did not significantly alter the inhibitory action of deoxypyridoxine [10].
• Effects of DL-alpha-difluoromethylornithine, 4-deoxypyridoxine and methylglyoxal bis(guanylhydrazone) on allograft prolongation [7].
• Based on this finding we advance the following two propositions for possible future medical application: (i) combination of deoxypyridoxine with immunosuppressive drugs in case of immunosuppressive therapy or organ transplantation [18].

References