The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

LOX  -  lysyl oxidase

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LOX


High impact information on LOX


Biological context of LOX


Anatomical context of LOX


Associations of LOX with chemical compounds


Physical interactions of LOX


Other interactions of LOX

  • Concentration of collagen, levels of mRNA for collagen type I subunits and for lysyl hydroxylase, and the level of three lysyl oxidase-derived cross-links: dehydro-dihydroxylysinonorleucine (DHLNL), dehydro-hydroxylysinonorleucine (HLNL), and dehydro-histidinohydroxymerodesmosine (HHMD) were determined during 4 wk posthatching [17].
  • Moreover, the H(2)O(2) released by lysyl oxidase in ESM was completely decomposed by coexisting catalase activity [16].

Analytical, diagnostic and therapeutic context of LOX


  1. Membrane proteases as potential diagnostic and therapeutic targets for breast malignancy. Chen, W.T., Lee, C.C., Goldstein, L., Bernier, S., Liu, C.H., Lin, C.Y., Yeh, Y., Monsky, W.L., Kelly, T., Dai, M. Breast Cancer Res. Treat. (1994) [Pubmed]
  2. Role of elastase and lysyl oxidase activity in spontaneous rupture of internal elastic lamina in rats. Osborne-Pellegrin, M.J., Farjanel, J., Hornebeck, W. Arteriosclerosis (1990) [Pubmed]
  3. Localization of lysyl oxidase in hen oviduct: implications in egg shell membrane formation and composition. Harris, E.D., Blount, J.E., Leach, R.M. Science (1980) [Pubmed]
  4. Lysyl oxidase activity and elastin/glycosaminoglycan interactions in growing chick and rat aortas. Fornieri, C., Baccarani-Contri, M., Quaglino, D., Pasquali-Ronchetti, I. J. Cell Biol. (1987) [Pubmed]
  5. Characterization and developmental expression of chick aortic lysyl oxidase. Wu, Y., Rich, C.B., Lincecum, J., Trackman, P.C., Kagan, H.M., Foster, J.A. J. Biol. Chem. (1992) [Pubmed]
  6. Collagen cross-linking. Purification and substrate specificity of lysyl oxidase. Siegel, R.C., Fu, J.C. J. Biol. Chem. (1976) [Pubmed]
  7. Activation of chick tendon lysyl oxidase in response to dietary copper. Rucker, R.B., Rucker, B.R., Mitchell, A.E., Cui, C.T., Clegg, M., Kosonen, T., Uriu-Adams, J.Y., Tchaparian, E.H., Fishman, M., Keen, C.L. J. Nutr. (1999) [Pubmed]
  8. A postabsorption effect of L-ascorbic acid on copper metabolism in chicks. Disilvestro, R.A., Harris, E.D. J. Nutr. (1981) [Pubmed]
  9. Copper-induced activation of aortic lysyl oxidase in vivo. Harris, E.D. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  10. Purification, properties and influence of dietary copper on accumulation and functional activity of lysyl oxidase in rat skin. Romero-Chapman, N., Lee, J., Tinker, D., Uriu-Hare, J.Y., Keen, C.L., Rucker, R.R. Biochem. J. (1991) [Pubmed]
  11. The effect of a vitamin B-6 antagonist, 4-deoxypyridoxine, on the cross-linking of collagen in the developing chick embryo. Bird, T.A., Levene, C.I. Biochem. J. (1983) [Pubmed]
  12. Role of copper in collagen cross-linking and its influence on selected mechanical properties of chick bone and tendon. Opsahl, W., Zeronian, H., Ellison, M., Lewis, D., Rucker, R.B., Riggins, R.S. J. Nutr. (1982) [Pubmed]
  13. Reaction of aortic lysyl oxidase with beta-aminopropionitrile. Tang, S.S., Trackman, P.C., Kagan, H.M. J. Biol. Chem. (1983) [Pubmed]
  14. Collagen cross-linking. Effect of D-penicillamine on cross-linking in vitro. Siegel, R.C. J. Biol. Chem. (1977) [Pubmed]
  15. The inhibition of lysyl oxidase in vivo by isoniazid and its reversal by pyridoxal. Effect on collagen cross-linking in the chick embryo. Carrington, M.J., Bird, T.A., Levene, C.I. Biochem. J. (1984) [Pubmed]
  16. Lysyl oxidase coupled with catalase in egg shell membrane. Akagawa, M., Wako, Y., Suyama, K. Biochim. Biophys. Acta (1999) [Pubmed]
  17. Developmental changes in skin collagen biosynthesis pathway in posthatch male and female chickens. Pines, M., Schickler, M., Hurwitz, S., Yamauchi, M. Poult. Sci. (1996) [Pubmed]
  18. Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage. Ito, H., Akiyama, H., Iguchi, H., Iyama, K., Miyamoto, M., Ohsawa, K., Nakamura, T. J. Biol. Chem. (2001) [Pubmed]
  19. An ultrafiltration assay for lysyl oxidase. Shackleton, D.R., Hulmes, D.J. Anal. Biochem. (1990) [Pubmed]
WikiGenes - Universities