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Chemical Compound Review

BBCE     3-(2- cyanoethylamino)propanenitrile

Synonyms: IDPN, NSC-7770, ACMC-1BTJR, CCRIS 4135, AG-D-30714, ...
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Disease relevance of Iminodiproprionitrile


Psychiatry related information on Iminodiproprionitrile


High impact information on Iminodiproprionitrile


Chemical compound and disease context of Iminodiproprionitrile


Biological context of Iminodiproprionitrile


Anatomical context of Iminodiproprionitrile


Associations of Iminodiproprionitrile with other chemical compounds


Gene context of Iminodiproprionitrile


Analytical, diagnostic and therapeutic context of Iminodiproprionitrile


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  2. Protection by 2-deoxy-D-glucose against beta,beta'-iminodipropionitrile-induced neurobehavioral toxicity in mice. Tariq, M., Khan, H.A., al Moutaery, K., al Deeb, S. Exp. Neurol. (1999) [Pubmed]
  3. Communicating hydrocephalus in rodents treated with beta,beta'-iminodipropionitrile (IDPN). Fiori, M.G., Sharer, L.R., Lowndes, H.E. Acta Neuropathol. (1985) [Pubmed]
  4. 3,3'-Iminodipropionitrile induces neurofilament accumulations in the perikarya of rat vestibular ganglion neurons. Llorens, J., Demêmes, D. Brain Res. (1996) [Pubmed]
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  10. Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile. Zhu, Q., Lindenbaum, M., Levavasseur, F., Jacomy, H., Julien, J.P. J. Cell Biol. (1998) [Pubmed]
  11. Microtubule-associated protein 2 within axons of spinal motor neurons: associations with microtubules and neurofilaments in normal and beta,beta'-iminodipropionitrile-treated axons. Papasozomenos, S.C., Binder, L.I., Bender, P.K., Payne, M.R. J. Cell Biol. (1985) [Pubmed]
  12. Cytoskeletal architecture and immunocytochemical localization of microtubule-associated proteins in regions of axons associated with rapid axonal transport: the beta,beta'-iminodipropionitrile-intoxicated axon as a model system. Hirokawa, N., Bloom, G.S., Vallee, R.B. J. Cell Biol. (1985) [Pubmed]
  13. Redistribution of proteins of fast axonal transport following administration of beta,beta'-iminodipropionitrile: a quantitative autoradiographic study. Papasozomenos, S.C., Yoon, M., Crane, R., Autilio-Gambetti, L., Gambetti, P. J. Cell Biol. (1982) [Pubmed]
  14. Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta'-iminodipropionitrile (IDPN) in the rat. Genter, M.B., Deamer, N.J., Cao, Y., Levi, P.E. J. Biochem. Toxicol. (1994) [Pubmed]
  15. Requirement of Vimentin Filament Assembly for beta3-Adrenergic Receptor Activation of ERK MAP Kinase and Lipolysis. Kumar, N., Robidoux, J., Daniel, K.W., Guzman, G., Floering, L.M., Collins, S. J. Biol. Chem. (2007) [Pubmed]
  16. Early effects of beta,beta'-iminodipropionitrile on tubulin solubility and neurofilament phosphorylation in the axon. Tashiro, T., Imai, R., Komiya, Y. J. Neurochem. (1994) [Pubmed]
  17. Alterations in flash evoked potentials (FEPs) in rats produced by 3,3'-iminodipropionitrile (IDPN). Herr, D.W., King, D., Barone, S., Crofton, K.M. Neurotoxicology and teratology. (1995) [Pubmed]
  18. Neurofilament gene expression following beta,beta'-iminodipropionitrile (IDPN) intoxication. Parhad, I.M., Swedberg, E.A., Hoar, D.I., Krekoski, C.A., Clark, A.W. Brain Res. (1988) [Pubmed]
  19. Developmental neurotoxicity following neonatal exposure to 3,3'-iminodipropionitrile in the rat. Crofton, K.M., Peele, D.B., Stanton, M.E. Neurotoxicology and teratology. (1993) [Pubmed]
  20. Actin immunoreactivity localizes with segregated microtubules and membraneous organelles and in the subaxolemmal region in the beta,beta'-iminodipropionitrile axon. Papasozomenos, S.C., Payne, M.R. J. Neurosci. (1986) [Pubmed]
  21. Microtubule-associated protein 2 (MAP2) is present in astrocytes of the optic nerve but absent from astrocytes of the optic tract. Papasozomenos, S.C., Binder, L.I. J. Neurosci. (1986) [Pubmed]
  22. Comparison of location, severity, and dose response of proximal axonal lesions induced by 3,3'-iminodipropionitrile and deuterium substituted analogs. Denlinger, R.H., Anthony, D.C., Amarnath, V., Graham, D.G. J. Neuropathol. Exp. Neurol. (1992) [Pubmed]
  23. Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy. Genter, M.B., Szakál-Quin, G., Anderson, C.W., Anthony, D.C., Graham, D.G. Toxicol. Appl. Pharmacol. (1987) [Pubmed]
  24. beta,beta'-Iminodipropionitrile-induced persistent dyskinetic syndrome in mice is transiently modified by MPTP. Fornai, F., Alessandri, M.G., Saginario, A., Vaglini, F., Corsini, G.U. Brain Res. (1993) [Pubmed]
  25. Occurrence of lipofuscin pigment granules and "dense microspheres" in the spinal cord of young cats treated with beta,beta'-iminodipropionitrile (IDPN). Fiori, M.G., Lowndes, H.E. Histol. Histopathol. (1988) [Pubmed]
  26. Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3'-iminodipropionitrile in male rats. Nace, C.G., Genter, M.B., Sayre, L.M., Crofton, K.M. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1997) [Pubmed]
  27. Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole. Genter, M.B., Owens, D.M., Carlone, H.B., Crofton, K.M. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]
  28. Schwann cell proliferation and migration during paranodal demyelination. Griffin, J.W., Drucker, N., Gold, B.G., Rosenfeld, J., Benzaquen, M., Charnas, L.R., Fahnestock, K.E., Stocks, E.A. J. Neurosci. (1987) [Pubmed]
  29. Age-related susceptibility to 3,3'-iminodipropionitrile-induced olfactory mucosal damage. Genter, M.B., Ali, S.F. Neurobiol. Aging (1998) [Pubmed]
  30. Increased Cu/Zn superoxide dismutase-like immunoreactivity in the swollen axons of rats intoxicated chronically with beta,beta'-iminodipropionitrile. Nishiyama, K., Kwak, S., Murayama, S., Watanabe, M., Goto, J., Asayama, K., Kanazawa, I. Neurosci. Lett. (1995) [Pubmed]
  31. Masses of phosphorylated neurofilaments are associated with abnormal golgi apparatus of anterior horn neurons of beta, beta'-iminodipropionitrile-intoxicated rats. Uesugi, M., Okamoto, K., Tanaka, M., Gonatas, N.K. Neuropathology : official journal of the Japanese Society of Neuropathology. (2002) [Pubmed]
  32. Origin of beading constrictions at the axolemma: presence in unmyelinated axons and after beta,beta'-iminodipropionitrile degradation of the cytoskeleton. Ochs, S., Pourmand, R., Jersild, R.A. Neuroscience (1996) [Pubmed]
  33. Carbonic anhydrase activity in the normal and injured peripheral nervous system of the rat. Peyronnard, J.M., Messier, J.P., Charron, L., Lavoie, J., Bergouignan, F.X., Dubreuil, M. Exp. Neurol. (1986) [Pubmed]
  34. Effect of capsaicin on neurites of cultured dorsal root ganglia and isolated neurons of chick embryos. Hiura, A., Sakamoto, Y. Neurosci. Lett. (1987) [Pubmed]
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