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Chemical Compound Review

L-T2     (2S)-2-amino-3-[4-(4- hydroxyphenoxy)-3,5...

Synonyms: ARONIS27078, SureCN445767, AG-A-47117, AG-D-15887, CHEMBL1877304, ...
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Disease relevance of Diiodothyronine


High impact information on Diiodothyronine


Biological context of Diiodothyronine


Anatomical context of Diiodothyronine


Associations of Diiodothyronine with other chemical compounds


Gene context of Diiodothyronine


Analytical, diagnostic and therapeutic context of Diiodothyronine


  1. The extrathyroidal conversion of 3,5,3'-triiodothyronine to 3,5-diiodothyronine in patients with liver cirrhosis. Faber, J., Kirkegaard, C., Thomsen, H.F., Lumholtz, I.B., Siersbaek-Nielsen, K., Friis, T. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  2. Simultaneous turnover studies of thyroxine, 3,5,3' and 3,3',5'-triiodothyronine, 3,5-, 3,3'-, and 3',5'- diiodothyronine, and 3'-monoiodothyronine in chronic renal failure. Faber, J., Heaf, J., Kirkegaard, C., Lumholtz, I.B., Siersbaek-Nielsen, K., Kølendorf, K., Friis, T. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  3. Elevated 3,5-diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors. Pinna, G., Meinhold, H., Hiedra, L., Thoma, R., Hoell, T., Gräf, K.J., Stoltenburg-Didinger, G., Eravci, M., Prengel, H., Brödel, O., Finke, R., Baumgartner, A. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  4. Effect of experimental chronic renal failure upon the synthesis of thyroid hormones in rats. Costa e Silva, A., Albuquerque, R.H., Santana, J.P. Nephron (1978) [Pubmed]
  5. Peripheral metabolism of T4, T3, reverse T3, 3',5'- diiodothyronine and 3,3' diiodothyronine in liver cirrhosis. Lumholtz, I.B., Faber, J., Sørensen, M.B., Kirkegaard, C., Siersbaek-Nielsen, K., Friis, T. Horm. Metab. Res. (1978) [Pubmed]
  6. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Pizzagalli, F., Hagenbuch, B., Stieger, B., Klenk, U., Folkers, G., Meier, P.J. Mol. Endocrinol. (2002) [Pubmed]
  7. Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase. Kadenbach, B., Hüttemann, M., Arnold, S., Lee, I., Bender, E. Free Radic. Biol. Med. (2000) [Pubmed]
  8. Simultaneous measurement of 3,5-diiodothyronine and 3,5,3'-triiodothyronine turnover kinetics in euthyroid hyperthyroid, and hypothyroid subjects. Faber, J., Kirkegaard, C., Lumholtz, I.B., Siersbaek-Nielsen, K., Friis, T. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  9. Radioimmunoassay for 3,5-diiodothyronine and evidence for dependence on conversion from 3,5,3'-triiodothyronine. Pangaro, L., Burman, K.D., Wartofsky, L., Cahnmann, H.J., Smallridge, R.C., O'Brian, J.T., Wright, F.D., Latham, K. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  10. Identification of 3,5-diiodo-L-thyronine-binding proteins in rat liver cytosol by photoaffinity labeling. Moreno, M., Silvestri, E., Lombardi, A., Visser, T.J., Goglia, F., Lanni, A. Endocrinology (2003) [Pubmed]
  11. Tissue iodothyronine levels in fetuses of control and hypothyroid rats at 13 and 16 days gestation. Porterfield, S.P., Hendrich, C.E. Endocrinology (1992) [Pubmed]
  12. New noncompetitive immunoassays of small analytes. Piran, U., Riordan, W.J., Livshin, L.A. Clin. Chem. (1995) [Pubmed]
  13. Control of energy metabolism by iodothyronines. Lanni, A., Moreno, M., Lombardi, A., de Lange, P., Goglia, F. J. Endocrinol. Invest. (2001) [Pubmed]
  14. 3,5-diiodo-L-thyronine powerfully reduces adiposity in rats by increasing the burning of fats. Lanni, A., Moreno, M., Lombardi, A., de Lange, P., Silvestri, E., Ragni, M., Farina, P., Baccari, G.C., Fallahi, P., Antonelli, A., Goglia, F. FASEB J. (2005) [Pubmed]
  15. Short-term effects of thyroid hormones and 3,5-diiodothyronine on membrane transport systems in chick embryo hepatocytes. Incerpi, S., De Vito, P., Luly, P., Spagnuolo, S., Leoni, S. Endocrinology (2002) [Pubmed]
  16. Concentrations of seven iodothyronine metabolites in brain regions and the liver of the adult rat. Pinna, G., Brödel, O., Visser, T., Jeitner, A., Grau, H., Eravci, M., Meinhold, H., Baumgartner, A. Endocrinology (2002) [Pubmed]
  17. Direct effects of 3,5,3'-triiodothyronine and 3,5-diiodothyronine on mitochondrial metabolism in the goldfish Carassius auratus. Leary, S.C., Barton, K.N., Ballantyne, J.S. Gen. Comp. Endocrinol. (1996) [Pubmed]
  18. 3,5-Diiodo-L-thyronine and 3,5,3'-triiodo-L-thyronine both improve the cold tolerance of hypothyroid rats, but possibly via different mechanisms. Lanni, A., Moreno, M., Lombardi, A., Goglia, F. Pflugers Arch. (1998) [Pubmed]
  19. Studies on the rapid stimulation of mitochondrial respiration by thyroid hormones. O'Reilly, I., Murphy, M.P. Acta Endocrinol. (1992) [Pubmed]
  20. A simple synthesis of [3,5-125I]Diiodo-L-thyroxine of high specific activity. Sorimachi, K., Cahnmann, H.J. Endocrinology (1977) [Pubmed]
  21. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Lanni, A., Moreno, M., Lombardi, A., Goglia, F. Mol. Cell. Endocrinol. (1994) [Pubmed]
  22. 3,5-diiodothyronine mimics the effect of triiodothyronine on insulin-like growth factor binding protein-4 expression in cultured rat hepatocytes. Demori, I., Gerdoni, E., Fugassa, E., Voci, A. Horm. Metab. Res. (2004) [Pubmed]
  23. Evaluation of thyroxine monodeiodination to reverse triiodothyronine by tissue homogenates in vitro. Brzezińska-Slebodzińska, E., Slebodziński, A.B., Drews, R. Endocrinol. Exp. (1983) [Pubmed]
  24. Effect of insulin, prednisolone and diiodothyronine on 3H-uridine intake and localization in Tetrahymena. Fülöp, A.K., Csaba, G. Acta morphologica Hungarica. (1990) [Pubmed]
  25. Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*. Li, X., Clemens, D.L., Anderson, R.J. Biochem. Pharmacol. (2000) [Pubmed]
  26. 3,5-diiodo-L-thyronine regulates glucose-6-phosphate dehydrogenase activity in the rat. Lombardi, A., Beneduce, L., Moreno, M., Diano, S., Colantuoni, V., Ursini, M.V., Lanni, A., Goglia, F. Endocrinology (2000) [Pubmed]
  27. 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP. Arnold, S., Goglia, F., Kadenbach, B. Eur. J. Biochem. (1998) [Pubmed]
  28. Structure-activity relation of thyroid hormone analogues and tissue epidermal growth factor concentrations in neonatal and adult mice. Hoath, S.B., Lakshmanan, J., Fisher, D.A. Am. J. Dis. Child. (1984) [Pubmed]
  29. A radioimmunoassay for measurement of 3,5-diiodothyronine. Maciel, R.M., Chopra, I.J., Ozawa, Y., Geola, F., Solomon, D.H. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  30. Effect of hapten heterology on thyroid hormone immunoassays. Piran, U., Riordan, W.J., Silbert, D.R. J. Immunol. Methods (1990) [Pubmed]
  31. Detection and semiquantitative estimation of thyroxine and diiodothyronine in liothyronine sodium. Cieri, U.R., Illuminati, J.C. Journal - Association of Official Analytical Chemists. (1977) [Pubmed]
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