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Chemical Compound Review

REVERSE TRIIODOTHYRONINE     (2S)-2-amino-3-[4-(4-hydroxy- 3,5-diiodo...

Synonyms: Reverse T3, SureCN93385, CHEMBL1743304, CHEBI:11684, rT(3), ...
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Psychiatry related information on REVERSE TRIIODOTHYRONINE


High impact information on REVERSE TRIIODOTHYRONINE

  • We have cloned and expressed a 2.1-kb human placental D3 cDNA which encodes a 32-kD protein with a Km of 1.2 nM for 5 deiodination of T3 and 340 nM for 5' deiodination of reverse T3 [10].
  • However, the in vivo administration to rats of IOP or 3,3',5'-triiodothyronine (rT3) resulted in a noncompetitive pattern of inhibition of 5'DI in the liver, kidney, and thyroid gland, whereby marked decreases in maximal enzyme velocity (V max) were noted, with no change in the value of the Michaelis-Menten constant [11].
  • Physiologic levels of 3,3',5'-triiodothyronine (rT3) are generally believed to have minimal metabolic effects in the pituitary gland and other tissues [1].
  • The changes in serum thyroid-stimulating hormone (TSH), serum total T4, 3,5,3'-triiodothyronine (T3), free T3, and 3,5',3'-triiodothyronine (reverse T3, rT3) were measured, and the pituitary reserve in TSH was evaluated by a thyrotropin-releasing hormone (TRH) test [12].
  • While 3, 3', 5'-triiodothyronine (reverse T3, rT3) has been detected both in human serum and in thyroglobulin, no quantitative assessment of its metabolic clearance rate (MCR), production rate (PR), or secretion by the thyroid is yet available [13].

Chemical compound and disease context of REVERSE TRIIODOTHYRONINE



  • Peak levels of interleukin 6 correlated negatively with T3 (P =.005) and positively with rT3 (P<.05), suggesting that down-regulation before AMI may be cardioprotective [19].
  • Reverse T3 (rT3) rose from 11 to 22 wk gestation without any effect of iodine status [20].
  • 3,3',5'-Triiodothyronine inhibits collagen-induced human platelet aggregation [21].
  • In those who survived, the most important changes within 48 h were seen in a normalization of cortisol and ACTH levels, but without a circadian rhythm; a decrease of rT3 and an increase in the T3/rT3 ratio; and a decrease in the levels of the nonesterified free fatty acids and an unaltered high urinary nitrogen excretion [22].
  • The binding protein for reverse T3 (NrT3BP) in the rat liver nuclear extract was neither immunoprecipitated nor influenced in its rT3-binding activity by 4BII-IgG [23].



Associations of REVERSE TRIIODOTHYRONINE with other chemical compounds

  • Pharmacokinetic significance of serum reverse T3 levels during amiodarone treatment: a potential method for monitoring chronic drug therapy [29].
  • Affinity labeling of p27 by 0.4 nM BrAc[125I]L-T4 was blocked by 0.1 microM of the alkylating ligands BrAcT4, BrAcT3, or 100 microM iodoacetate, by 10 microM concentrations of the non-alkylating, reversible ligands N-acetyl-L-thyroxine, 3,3',5'-triiodothyronine, 3,5-diiodosalicylate, and EMD 21388, a T4-antagonistic flavonoid [30].
  • Patients with supranormal serum free T4 concentrations (21 percent) ahd higher serum T4, lower serum T3, and higher serum reverse T3 (rT3) concentrations than other patients, but the measured changes in serum T4, TBG and TBPA levels could only partly account for the magnitude of the free T4 elevation [31].
  • Significant increases in TSH, T4, fT4, T3, fT3, rT3, and cortisol and decreases in prolactin levels occurred during the night of SD, compared to the pattern during the night of sleep [32].
  • Both pregnancy and estrogen administration were associated with increases in serum reverse T3 concentrations presumably because of their ability to augment thyroxine binding globulin synthesis [27].


  • Apparent K(m) values for 3,3',5-triiodothyronine (T(3)), 3, 3'-diiodothyronine (3,3'-T(2)), 3',5',3-triiodothyronine (rT(3)), and 3,3',5,5'-tetraiodothyronine (T(4)) with SULT1C1 were 28.7, 10.3, 10.2, and 59.3 microM, respectively [33].
  • METHODS: Fifty-two HIV-infected children receiving HAART were assessed for signs of thyroid dysfunction and serum concentrations of thyrotropin (TSH), free thyroxin (FT4), free triiodothyronine (FT3), thyroglobulin (TG), reverse triiodothyronine (rT3), anti-TG and antimicrosomal (anti-TSM) antibodies [34].
  • The pro-hormone T4 (3,3',5,5'-triiodothyronine) is converted in the brain to its active form, T3, or its inactive metabolite, reverse T3, mainly by the action of deiodinase type 2 (DIO2) [35].
  • Studies on the nature of thyroidal suppression during acute falciparum malaria: integrity of pituitary response to TRH and alterations in serum T3 and reverse T3 [36].
  • Two groups of rats were infused with leptin for 6 days, one of them being additionally treated with reverse triiodothyronine (rT3), an inhibitor of D2 [37].

Analytical, diagnostic and therapeutic context of REVERSE TRIIODOTHYRONINE


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  2. Letter: Reverse T3 in screening for neonatal hypothyroidism. Burger, A., Buerer, T., Sizonenko, n.u.l.l., Lacourt, G. Lancet (1976) [Pubmed]
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  6. Increased cerebrospinal fluid levels of 3,3',5'-triiodothyronine in patients with Alzheimer's disease. Sampaolo, S., Campos-Barros, A., Mazziotti, G., Carlomagno, S., Sannino, V., Amato, G., Carella, C., Di Iorio, G. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
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  12. Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxin, and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones. Burger, A., Dinichert, D., Nicod, P., Jenny, M., Lemarchand-Béraud, T., Vallotton, M.B. J. Clin. Invest. (1976) [Pubmed]
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  14. Serum thyroid hormone levels in patients with liver disease. Hepner, G.W., Chopra, I.J. Arch. Intern. Med. (1979) [Pubmed]
  15. T3 may be a better agent than T4 in the critically ill hypothyroid patient: evaluation of transport across the blood-brain barrier in a primate model. Chernow, B., Burman, K.D., Johnson, D.L., McGuire, R.A., O'Brian, J.T., Wartofsky, L., Georges, L.P. Crit. Care Med. (1983) [Pubmed]
  16. Hormonal changes in brain dead patients. Powner, D.J., Hendrich, A., Lagler, R.G., Ng, R.H., Madden, R.L. Crit. Care Med. (1990) [Pubmed]
  17. Thyroid hormone in neural rescue. D'Alecy, L.G. Thyroid (1997) [Pubmed]
  18. Amiodarone, thyroid hormone indexes, and altered thyroid function: long-term serial effects in patients with cardiac arrhythmias. Nademanee, K., Singh, B.N., Callahan, B., Hendrickson, J.A., Hershman, J.M. Am. J. Cardiol. (1986) [Pubmed]
  19. Rapid down-regulation of thyroid hormones in acute myocardial infarction: is it cardioprotective in patients with angina? Friberg, L., Werner, S., Eggertsen, G., Ahnve, S. Arch. Intern. Med. (2002) [Pubmed]
  20. 5'-Monodeiodinase activity in developing human cerebral cortex. Karmarkar, M.G., Prabarkaran, D., Godbole, M.M. Am. J. Clin. Nutr. (1993) [Pubmed]
  21. 3,3',5'-Triiodothyronine inhibits collagen-induced human platelet aggregation. Masaki, H., Nishikawa, M., Urakami, M., Yoshimura, M., Toyoda, N., Mori, Y., Yoshikawa, N., Inada, M. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  22. Endocrine and metabolic responses in children with meningoccocal sepsis: striking differences between survivors and nonsurvivors. Joosten, K.F., de Kleijn, E.D., Westerterp, M., de Hoog, M., Eijck, F.C., Hop WCJ, n.u.l.l., Voort, E.V., Hazelzet, J.A., Hokken-Koelega, A.C. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
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  26. Measurement of 3,3',5'-Triiodothyroinine (reverse T3), 3,3'-L-diiodothyronine, T3 and T4 in human amniotic fluid and in cord and maternal serum. Burman, K.D., Read, J., Dimond, R.C., Strum, D., Wright, F.D., Patow, W., Earll, J.M., Wartofsky, L. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  27. A radioimmunoassay for 3,3',5'-L-triiodothyronine (reverse T3): assessment of thyroid gland content and serum measurements in conditions of normal and altered thyroidal economy and following administration of thyrotropin releasing hormone (TRH) and thyrotropin (TSH). Burman, K.D., Dimond, R.C., Wright, F.D., Earll, J.M., Bruton, J., Wartofsky, L. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  28. The effect of thyroidectomy in the fetal sheep on lung liquid reabsorption induced by adrenaline or cyclic AMP. Barker, P.M., Brown, M.J., Ramsden, C.A., Strang, L.B., Walters, D.V. J. Physiol. (Lond.) (1988) [Pubmed]
  29. Pharmacokinetic significance of serum reverse T3 levels during amiodarone treatment: a potential method for monitoring chronic drug therapy. Nademanee, K., Singh, B.N., Hendrickson, J.A., Reed, A.W., Melmed, S., Hershman, J. Circulation (1982) [Pubmed]
  30. Selective affinity labeling of a 27-kDa integral membrane protein in rat liver and kidney with N-bromoacetyl derivatives of L-thyroxine and 3,5,3'-triiodo-L-thyronine. Köhrle, J., Rasmussen, U.B., Rokos, H., Leonard, J.L., Hesch, R.D. J. Biol. Chem. (1990) [Pubmed]
  31. Prevalence of abnormal thyroid function test results in patients with acute medical illnesses. Kaplan, M.M., Larsen, P.R., Crantz, F.R., Dzau, V.J., Rossing, T.H., Haddow, J.E. Am. J. Med. (1982) [Pubmed]
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  35. Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China. Guo, T.W., Zhang, F.C., Yang, M.S., Gao, X.C., Bian, L., Duan, S.W., Zheng, Z.J., Gao, J.J., Wang, H., Li, R.L., Feng, G.Y., St Clair, D., He, L. J. Med. Genet. (2004) [Pubmed]
  36. Studies on the nature of thyroidal suppression during acute falciparum malaria: integrity of pituitary response to TRH and alterations in serum T3 and reverse T3. Wartofsky, L., Burman, K.D., Dimond, R.C., Noel, G.L., Frantz, A.G., Earll, J.M. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  37. Central stimulatory effect of leptin on T3 production is mediated by brown adipose tissue type II deiodinase. Cettour-Rose, P., Burger, A.G., Meier, C.A., Visser, T.J., Rohner-Jeanrenaud, F. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
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  39. Effect of caloric restriction and dietary composition of serum T3 and reverse T3 in man. Spaulding, S.W., Chopra, I.J., Sherwin, R.S., Lyall, S.S. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
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