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Chemical Compound Review

NICKEL     nickel

Synonyms: niccolum, Fibrex, niquel, Fibrex P, Nickel 200, ...
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Disease relevance of nickel


High impact information on nickel


Biological context of nickel


Anatomical context of nickel

  • We have purified and partially characterized a Ni(2+)-binding protein (p40) from HeLa cell extracts that can specifically enhance the polymerase activity of DNA polymerase alpha (pol alpha) and other DNA polymerases in response to Ni2+ [2].
  • Nickel ion (0.66 mM) terminated all spontaneous motility, while only reducing microtubule sliding rates to approximately or equal to 5.0 microns/sec [16].
  • Nickel ion transport into vacuoles in a pH gradient-dependent manner is thus important for its detoxification in yeast [17].
  • Thus, the purpose of the current study was to assess longer-term effects of ions of silver, copper, mercury, and nickel - four metal ions known to be released from dental alloys - on monocytes [18].
  • Nickel compounds are carcinogenic and induce malignant transformation of cultured cells [19].

Associations of nickel with other chemical compounds


Gene context of nickel

  • Gel permeation chromatography of radiolabeled hydrocarbons released from the rac1, rac2, and ralA proteins by reaction with Raney nickel catalyst indicated that unlike p21Hras, which was modified by a 15-carbon moiety, the rac and ralA translation products were modified by 20-carbon isoprenyl groups [25].
  • Raney nickel converted both of these thio sugar derivatives into the same product, namely, 1-acetamido-1,2-dideoxy-3,4:5,6-di-O-isopropylidene-2-C-methyl-D-mannito l [26].
  • Treatment of aprotinin with Raney nickel in the presence or absence of denaturants yielded [Ala2 14,38]aprotinin [27].
  • Vegetative cells were resistant to some extent to various levels of salt (NaCl, < or = 0.8 mol/L), pesticides (DDT, 2,4-D or captan, 2000 ppm) and 'heavy' metals (zinc or nickel, 200 ppm; cobalt, < or = 100 ppm.)[28]

Analytical, diagnostic and therapeutic context of nickel


  1. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Li, J., Davidson, G., Huang, Y., Jiang, B.H., Shi, X., Costa, M., Huang, C. Cancer Res. (2004) [Pubmed]
  2. A single stranded DNA binding protein isolated from HeLa cells facilitates Ni2+ activation of DNA polymerases in vitro. Chin, Y.E., Snow, E.T., Christie, N.T. Biochemistry (1994) [Pubmed]
  3. Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen. Hong, Y.C., Paik, S.R., Lee, H.J., Lee, K.H., Jang, S.M. Environ. Health Perspect. (1997) [Pubmed]
  4. Identification of three classes of hydrogenase in the genus, Desulfovibrio. Prickril, B.C., He, S.H., Li, C., Menon, N., Choi, E.S., Przybyla, A.E., DerVartanian, D.V., Peck, H.D., Fauque, G., LeGall, J. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  5. Interactions of orthopaedic metals with an immortalized rat osteoblast cell line. McKay, G.C., Macnair, R., MacDonald, C., Grant, M.H. Biomaterials (1996) [Pubmed]
  6. Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus. Yamane, H.K., Farnsworth, C.C., Xie, H.Y., Evans, T., Howald, W.N., Gelb, M.H., Glomset, J.A., Clarke, S., Fung, B.K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  7. Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini. Yamane, H.K., Farnsworth, C.C., Xie, H.Y., Howald, W., Fung, B.K., Clarke, S., Gelb, M.H., Glomset, J.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  8. Nickel compounds are novel inhibitors of histone H4 acetylation. Broday, L., Peng, W., Kuo, M.H., Salnikow, K., Zoroddu, M., Costa, M. Cancer Res. (2000) [Pubmed]
  9. The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization. Dalton, M.B., Fantle, K.S., Bechtold, H.A., DeMaio, L., Evans, R.M., Krystosek, A., Sinensky, M. Cancer Res. (1995) [Pubmed]
  10. The posttranslationally modified C-terminal structure of bovine aortic smooth muscle rhoA p21. Katayama, M., Kawata, M., Yoshida, Y., Horiuchi, H., Yamamoto, T., Matsuura, Y., Takai, Y. J. Biol. Chem. (1991) [Pubmed]
  11. Sterols affecting meiosis: novel chemical syntheses and the biological activity and spectral properties of the synthetic sterols. Ruan, B., Watanabe, S., Eppig, J.J., Kwoh, C., Dzidic, N., Pang, J., Wilson, W.K., Schroepfer, G.J. J. Lipid Res. (1998) [Pubmed]
  12. Coenzyme A biosynthesis: steric course of 4'-phosphopantothenoyl-L-cysteine decarboxylase. Aberhart, D.J., Ghoshal, P.K., Cotting, J.A., Russell, D.J. Biochemistry (1985) [Pubmed]
  13. Synthesis of novel KDR kinase inhibitors through catalytic reductive cyclization of o-nitrobenzylcarbonyl compounds. Wong, A., Kuethe, J.T., Davies, I.W., Hughes, D.L. J. Org. Chem. (2004) [Pubmed]
  14. Effects of nickel on DNA methyltransferase activity and genomic DNA methylation levels. Lee, Y.W., Broday, L., Costa, M. Mutat. Res. (1998) [Pubmed]
  15. Mechanisms of biosorption of different heavy metals by brown marine macroalgae. Raize, O., Argaman, Y., Yannai, S. Biotechnol. Bioeng. (2004) [Pubmed]
  16. Interdoublet sliding in bovine spermatozoa: its relationship to flagellar motility and the action of inhibitory agents. Bird, Z., Hard, R., Kanous, K.S., Lindemann, C.B. J. Struct. Biol. (1996) [Pubmed]
  17. Proton gradient-driven nickel uptake by vacuolar membrane vesicles of Saccharomyces cerevisiae. Nishimura, K., Igarashi, K., Kakinuma, Y. J. Bacteriol. (1998) [Pubmed]
  18. Effect of silver, copper, mercury, and nickel ions on cellular proliferation during extended, low-dose exposures. Wataha, J.C., Lockwood, P.E., Schedle, A. J. Biomed. Mater. Res. (2000) [Pubmed]
  19. Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas. Kowara, R., Salnikow, K., Diwan, B.A., Bare, R.M., Waalkes, M.P., Kasprzak, K.S. Mol. Cell. Biochem. (2004) [Pubmed]
  20. Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. Liu, M.C., Lin, T.S., Cory, J.G., Cory, A.H., Sartorelli, A.C. J. Med. Chem. (1996) [Pubmed]
  21. New anticancer agents: synthesis of 1,2-dihydropyrido[3,4-b]pyrazines (1-deaza-7,8-dihydropteridines). Temple, C., Wheeler, G.P., Elliott, R.D., Rose, J.D., Kussner, C.L., Comber, R.N., Montgomery, J.A. J. Med. Chem. (1982) [Pubmed]
  22. Measurement of adducts of benzoquinone with hemoglobin and albumin. McDonald, T.A., Waidyanatha, S., Rappaport, S.M. Carcinogenesis (1993) [Pubmed]
  23. Asymmetric synthesis of deoxypolypropionate units via stereoselective hydrogenation of optically active cycloheptatriene. Sugimura, T., Sato, Y., Im, C.Y., Okuyama, T. Org. Lett. (2004) [Pubmed]
  24. Application of Raney nickel to measure adducts of styrene oxide with hemoglobin and albumin. Rappaport, S.M., Ting, D., Jin, Z., Yeowell-O'Connell, K., Waidyanatha, S., McDonald, T. Chem. Res. Toxicol. (1993) [Pubmed]
  25. Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. Kinsella, B.T., Erdman, R.A., Maltese, W.A. J. Biol. Chem. (1991) [Pubmed]
  26. Nucleophilic ring-opening in a carbohydrate nitrocyclopropane: a stereospecific approach to chiral isoalkyl structures. Baer, H.H., Williams, U., Radatus, B. Carbohydr. Res. (1988) [Pubmed]
  27. [Ala214,38]aprotinin: preparation by partial desulphurization of aprotinin by means of Raney nickel and comparison with other aprotinin derivatives. Schnabel, E., Schröder, W., Reinhardt, G. Biol. Chem. Hoppe-Seyler (1986) [Pubmed]
  28. Vegetative survival and reproduction under submerged and air-exposed conditions and vegetative survival as affected by salts, pesticides, and metals in aerial green alga Trentepohlia aurea. Gupta, S., Agrawal, S.C. Folia Microbiol. (Praha) (2004) [Pubmed]
  29. Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine. Kawata, M., Farnsworth, C.C., Yoshida, Y., Gelb, M.H., Glomset, J.A., Takai, Y. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  30. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Huang, C., Li, J., Costa, M., Zhang, Z., Leonard, S.S., Castranova, V., Vallyathan, V., Ju, G., Shi, X. Cancer Res. (2001) [Pubmed]
  31. Vibrational spectroscopy and structures of Ni+(C2H2)(n) (n =1-4) complexes. Walters, R.S., Pillai, E.D., Schleyer, P.V., Duncan, M.A. J. Am. Chem. Soc. (2005) [Pubmed]
  32. Transformation of human osteoblasts to anchorage-independent growth by insoluble nickel particles. Lin, X., Costa, M. Environ. Health Perspect. (1994) [Pubmed]
  33. Depletion of mitochondrial coenzyme A and glutathione by 4-dimethylaminophenol and formation of mixed thioethers. Eckert, K.G., Elbers, F.R., Eyer, P. Biochem. Pharmacol. (1989) [Pubmed]
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