Gene Review:
Irf8 - interferon regulatory factor 8
Mus musculus
Synonyms:
AI893568, ICSBP, IRF-8, Icsbp, Icsbp1, ...
- A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. Turcotte, K., Gauthier, S., Tuite, A., Mullick, A., Malo, D., Gros, P. J. Exp. Med. (2005)
- Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis. Fehr, T., Schoedon, G., Odermatt, B., Holtschke, T., Schneemann, M., Bachmann, M.F., Mak, T.W., Horak, I., Zinkernagel, R.M. J. Exp. Med. (1997)
- ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro. Tsujimura, H., Tamura, T., Gongora, C., Aliberti, J., Reis e Sousa, C., Sher, A., Ozato, K. Blood (2003)
- Interferon-gamma induces regression of epithelial cell carcinoma: critical roles of IRF-1 and ICSBP transcription factors. Egwuagu, C.E., Li, W., Yu, C.R., Che Mei Lin, M., Chan, C.C., Nakamura, T., Chepelinsky, A.B. Oncogene (2006)
- Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages. Kallies, A., Rosenbauer, F., Scheller, M., Knobeloch, K.P., Horak, I. Blood (2002)
- ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages. Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T., Ozato, K. Immunity (2000)
- Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease. Middleton, M.K., Zukas, A.M., Rubinstein, T., Jacob, M., Zhu, P., Zhao, L., Blair, I., Pur??, E. J. Exp. Med. (2006)
- Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. Scharton-Kersten, T., Contursi, C., Masumi, A., Sher, A., Ozato, K. J. Exp. Med. (1997)
- Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages. Rosenbauer, F., Waring, J.F., Foerster, J., Wietstruk, M., Philipp, D., Horak, I. Blood (1999)
- Complex formation of the interferon (IFN) consensus sequence-binding protein with IRF-1 is essential for murine macrophage IFN-gamma-induced iNOS gene expression. Xiong, H., Zhu, C., Li, H., Chen, F., Mayer, L., Ozato, K., Unkeless, J.C., Plevy, S.E. J. Biol. Chem. (2003)
- Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation. Nelson, N., Kanno, Y., Hong, C., Contursi, C., Fujita, T., Fowlkes, B.J., O'Connell, E., Hu-Li, J., Paul, W.E., Jankovic, D., Sher, A.F., Coligan, J.E., Thornton, A., Appella, E., Yang, Y., Ozato, K. J. Immunol. (1996)
- Interferon regulatory factor 8 regulates RANTES gene transcription in cooperation with interferon regulatory factor-1, NF-kappaB, and PU.1. Liu, J., Ma, X. J. Biol. Chem. (2006)
- Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Tamura, T., Thotakura, P., Tanaka, T.S., Ko, M.S., Ozato, K. Blood (2005)
- Modulation of interferon consensus sequence binding protein mRNA in murine peritoneal macrophages. Induction by IFN-gamma and down-regulation by IFN-alpha, dexamethasone, and protein kinase inhibitors. Politis, A.D., Sivo, J., Driggers, P.H., Ozato, K., Vogel, S.N. J. Immunol. (1992)
- Toward the identification of a tolerogenic signature in IDO-competent dendritic cells. Orabona, C., Puccetti, P., Vacca, C., Bicciato, S., Luchini, A., Fallarino, F., Bianchi, R., Velardi, E., Perruccio, K., Velardi, A., Bronte, V., Fioretti, M.C., Grohmann, U. Blood (2006)
- IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages. Kim, Y.M., Im, J.Y., Han, S.H., Kang, H.S., Choi, I. J. Immunol. (2000)
- LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Sester, D.P., Trieu, A., Brion, K., Schroder, K., Ravasi, T., Robinson, J.A., McDonald, R.C., Ripoll, V., Wells, C.A., Suzuki, H., Hayashizaki, Y., Stacey, K.J., Hume, D.A., Sweet, M.J. Immunobiology (2005)
- ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells. Tamura, T., Kong, H.J., Tunyaplin, C., Tsujimura, H., Calame, K., Ozato, K. Blood (2003)
- AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. Schwieger, M., Löhler, J., Friel, J., Scheller, M., Horak, I., Stocking, C. J. Exp. Med. (2002)
- Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein. Gabriele, L., Phung, J., Fukumoto, J., Segal, D., Wang, I.M., Giannakakou, P., Giese, N.A., Ozato, K., Morse, H.C. J. Exp. Med. (1999)
- Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Aliberti, J., Schulz, O., Pennington, D.J., Tsujimura, H., Reis e Sousa, C., Ozato, K., Sher, A. Blood (2003)
- Interferon consensus sequence binding protein confers resistance against Yersinia enterocolitica. Hein, J., Kempf, V.A., Diebold, J., Bücheler, N., Preger, S., Horak, I., Sing, A., Kramer, U., Autenrieth, I.B. Infect. Immun. (2000)
- Differential expression of inducible nitric oxide synthase and IL-12 between peritoneal and splenic macrophages stimulated with LPS plus IFN-gamma is associated with the activation of extracellular signal-related kinase. Zhu, Y.N., Yang, Y.F., Ono, S., Zhong, X.G., Feng, Y.H., Ren, Y.X., Ni, J., Fu, Y.F., Tang, W., Zuo, J.P. Int. Immunol. (2006)