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Remslp1  -  rapid eye movement sleep 1

Mus musculus

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Disease relevance of Remslp1


Psychiatry related information on Remslp1


High impact information on Remslp1

  • Ectopic expression of a prepro-orexin transgene in the brain completely prevented cataplectic arrests and other abnormalities of rapid eye movement sleep in the absence of endogenous orexin neurons [7].
  • Although TNFR-KO mice failed to respond to TNFalpha, they had an increase in NREMS and a decrease in rapid eye movement sleep after interleukin-1beta treatment [11].
  • At 2 months of age, REMS was indistinguishable by genotype but was reduced in Tg2576 mice at 6 and 12 months [9].
  • We sought to determine whether abnormal beta-amyloid peptides impair REMS and injure mesopontine cholinergic neurons in transgenic (hAPP695.SWE) mice (Tg2576) that model brain amyloid pathologies [9].
  • Based upon spectral analysis the EEG was classified into three categories: awake, slow-wave sleep (SWS), and rapid eye movement sleep (REM) [12].

Chemical compound and disease context of Remslp1


Biological context of Remslp1


Anatomical context of Remslp1


Associations of Remslp1 with chemical compounds


Regulatory relationships of Remslp1


Other interactions of Remslp1


Analytical, diagnostic and therapeutic context of Remslp1


  1. Alterations in EEG activity and sleep after influenza viral infection in GHRH receptor-deficient mice. Alt, J.A., Obal, F., Traynor, T.R., Gardi, J., Majde, J.A., Krueger, J.M. J. Appl. Physiol. (2003) [Pubmed]
  2. Detection of toxic viral-associated double-stranded RNA (dsRNA) in influenza-infected lung. Majde, J.A., Brown, R.K., Jones, M.W., Dieffenbach, C.W., Maitra, N., Krueger, J.M., Cady, A.B., Smitka, C.W., Maassab, H.F. Microb. Pathog. (1991) [Pubmed]
  3. Sleep apnea and effect of chemostimulation on breathing instability in mice. Nakamura, A., Fukuda, Y., Kuwaki, T. J. Appl. Physiol. (2003) [Pubmed]
  4. Sleep in mice with nonfunctional growth hormone-releasing hormone receptors. Obal, F., Alt, J., Taishi, P., Gardi, J., Krueger, J.M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  5. Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse. Polotsky, V.Y., Rubin, A.E., Balbir, A., Dean, T., Smith, P.L., Schwartz, A.R., O'Donnell, C.P. Sleep Med. (2006) [Pubmed]
  6. A quantitative genetic analysis of slow-wave sleep and rapid-eye movement sleep in CXB recombinant inbred mice. Toth, L.A., Williams, R.W. Behav. Genet. (1999) [Pubmed]
  7. Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Mieda, M., Willie, J.T., Hara, J., Sinton, C.M., Sakurai, T., Yanagisawa, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. Hypocretin/orexin, sleep and narcolepsy. Hungs, M., Mignot, E. Bioessays (2001) [Pubmed]
  9. Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. Zhang, B., Veasey, S.C., Wood, M.A., Leng, L.Z., Kaminski, C., Leight, S., Abel, T., Lee, V.M., Trojanowski, J.Q. Am. J. Pathol. (2005) [Pubmed]
  10. Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. Huitron-Resendiz, S., Sanchez-Alavez, M., Wills, D.N., Cravatt, B.F., Henriksen, S.J. Sleep. (2004) [Pubmed]
  11. Mice lacking the TNF 55 kDa receptor fail to sleep more after TNFalpha treatment. Fang, J., Wang, Y., Krueger, J.M. J. Neurosci. (1997) [Pubmed]
  12. Spectral analysis of mouse EEG after the administration of N,N-dimethyltryptamine. Morley, B.J., Bradley, R.J. Biol. Psychiatry (1977) [Pubmed]
  13. CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat. Edgar, D.M., Seidel, W.F., Gee, K.W., Lan, N.C., Field, G., Xia, H., Hawkinson, J.E., Wieland, S., Carter, R.B., Wood, P.L. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  14. A comparison of thalidomide and pentobarbital - new methods for identifying novel hypnotic drugs. Frederickson, R.C., Slater, I.H., Dusenberry, W.E., Hewes, C.R., Jones, G.T., Moore, R.A. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
  15. Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. Alexandre, C., Popa, D., Fabre, V., Bouali, S., Venault, P., Lesch, K.P., Hamon, M., Adrien, J. J. Neurosci. (2006) [Pubmed]
  16. Sleep EEG changes after middle cerebral artery infarcts in mice: different effects of striatal and cortical lesions. Baumann, C.R., Kilic, E., Petit, B., Werth, E., Hermann, D.M., Tafti, M., Bassetti, C.L. Sleep. (2006) [Pubmed]
  17. Sleep in female mice: a strain comparison across the estrous cycle. Koehl, M., Battle, S.E., Turek, F.W. Sleep. (2003) [Pubmed]
  18. Microinjection of neostigmine into the pontine reticular formation of C57BL/6J mouse enhances rapid eye movement sleep and depresses breathing. Lydic, R., Douglas, C.L., Baghdoyan, H.A. Sleep. (2002) [Pubmed]
  19. Mice deficient in the interferon type I receptor have reduced REM sleep and altered hypothalamic hypocretin, prolactin and 2',5'-oligoadenylate synthetase expression. Bohnet, S.G., Traynor, T.R., Majde, J.A., Kacsoh, B., Krueger, J.M. Brain Res. (2004) [Pubmed]
  20. Influence of regular voluntary exercise on spontaneous and social stress-affected sleep in mice. Lancel, M., Droste, S.K., Sommer, S., Reul, J.M. Eur. J. Neurosci. (2003) [Pubmed]
  21. Behavioral and electroencephalographic properties of duloxetine (LY248686), a reuptake inhibitor of norepinephrine and serotonin, in mice and rats. Katoh, A., Eigyo, M., Ishibashi, C., Naitoh, Y., Takeuchi, M., Ibii, N., Ikeda, M., Matsushita, A. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  22. Differential cholinergic activation of G proteins in rat and mouse brainstem: relevance for sleep and nociception. Demarco, G.J., Baghdoyan, H.A., Lydic, R. J. Comp. Neurol. (2003) [Pubmed]
  23. Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. II. Pharmacological profile. Caille, D., Bergis, O.E., Fankhauser, C., Gardes, A., Adam, R., Charieras, T., Grosset, A., Rovei, V., Jarreau, F.X. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  24. 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. Martin, J.R., Bös, M., Jenck, F., Moreau, J., Mutel, V., Sleight, A.J., Wichmann, J., Andrews, J.S., Berendsen, H.H., Broekkamp, C.L., Ruigt, G.S., Köhler, C., Delft, A.M. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  25. The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha. Chen, L., Taishi, P., Majde, J.A., Peterfi, Z., Obal, F., Krueger, J.M. Brain Behav. Immun. (2004) [Pubmed]
  26. Effects of interleukin-1 beta on sleep are mediated by the type I receptor. Fang, J., Wang, Y., Krueger, J.M. Am. J. Physiol. (1998) [Pubmed]
  27. M2 muscarinic receptors in pontine reticular formation of C57BL/6J mouse contribute to rapid eye movement sleep generation. Coleman, C.G., Lydic, R., Baghdoyan, H.A. Neuroscience (2004) [Pubmed]
  28. Rapid eye movement sleep is reduced in prolactin-deficient mice. Obál, F., Garcia-Garcia, F., Kacsóh, B., Taishi, P., Bohnet, S., Horseman, N.D., Krueger, J.M. J. Neurosci. (2005) [Pubmed]
  29. Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission. Wisor, J.P., Edgar, D.M., Yesavage, J., Ryan, H.S., McCormick, C.M., Lapustea, N., Murphy, G.M. Neuroscience (2005) [Pubmed]
  30. Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases. Chen, L., Duricka, D., Nelson, S., Mukherjee, S., Bohnet, S.G., Taishi, P., Majde, J.A., Krueger, J.M. J. Appl. Physiol. (2004) [Pubmed]
  31. Behavioral state instability in orexin knock-out mice. Mochizuki, T., Crocker, A., McCormack, S., Yanagisawa, M., Sakurai, T., Scammell, T.E. J. Neurosci. (2004) [Pubmed]
  32. REM sleep control during aging in SAM mice: a role for inducible nitric oxide synthase. Colas, D., Bezin, L., Gharib, A., Morales, A., Cespuglio, R., Sarda, N. Neurobiol. Aging (2005) [Pubmed]
  33. The effects of flumazenil, Ro 154513 and beta-CCM on the behaviour of control and stressed mice in the staircase test. Pokk, P., Väli, M. J. Psychopharmacol. (Oxford) (2001) [Pubmed]
  34. Effect of alpha 2-adrenergic drugs on REM sleep deprivation-induced increase in swimming activity. Asakura, W., Matsumoto, K., Ohta, H., Watanabe, H. Pharmacol. Biochem. Behav. (1993) [Pubmed]
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