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Gene Review

Aldoc  -  aldolase C, fructose-bisphosphate

Rattus norvegicus

Synonyms: ALDCAA, Brain-type aldolase, F16dip7, Fructose-bisphosphate aldolase C, RATALDCAA
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Disease relevance of Aldoc


High impact information on Aldoc

  • It is located in cerebellar Purkinje cells, and the highest concentrations are seen in ones expressing high levels of zebrin II (aldolase C) [6].
  • Novel target sequences for Pax-6 in the brain-specific activating regions of the rat aldolase C gene [7].
  • Upstream elements involved in vivo in activation of the brain-specific rat aldolase C gene. Role of binding sites for POU and winged helix proteins [8].
  • A protein of molecular mass 40 kDa, which was detected by anti-PLD antibody with overlaying of the purified PLD2, is shown to be aldolase C by peptide-mass fingerprinting with matrix-assisted laser desorption/ionization-time-of flight mass spectrometry (MALDI-TOF-MS) [9].
  • The site of phosphorylation was identified as Asp-319 on aldolase C. The equivalent residue on aldolase A, a glutamic residue, was not phosphorylated [10].

Biological context of Aldoc


Anatomical context of Aldoc


Associations of Aldoc with chemical compounds

  • The dislocations of the Aldoc mRNA bands did not occur after a single methamphetamine injection and thus repeated injections were necessary to change the distributions of the lateral bands [19].
  • We concluded that excess dopamine selectively changes the location of the Aldoc mRNA compartments in the vermis while the SLC1A 6 mRNA stripes could be changed by other inputs and thus the specific transmitter system might change the specific compartment of the cerebellum [19].
  • The sequence around Asp-319 of aldolase C has some similarities to those around the histidine residues on ATP-citrate lyase and succinic thiokinase that are phosphorylated by nm23 proteins [10].
  • Histidine to aspartate phosphotransferase activity of nm23 proteins: phosphorylation of aldolase C on Asp-319 [10].
  • Several of the altered proteins (heat shock proteins 60 and 72, albumin, dihydropyrimidinase related protein-2, aldolase c, and malate dehydrogenase) have previously been connected to schizophrenia [20].

Other interactions of Aldoc


Analytical, diagnostic and therapeutic context of Aldoc


  1. The structure of brain-specific rat aldolase C mRNA and the evolution of aldolase isozyme genes. Kukita, A., Mukai, T., Miyata, T., Hori, K. Eur. J. Biochem. (1988) [Pubmed]
  2. Aldolase C in cultrued rat glioma. Kumanishi, T., Ikuta, F., Yamamoto, T., Maruyama, N., Nishida, K. J. Neurochem. (1975) [Pubmed]
  3. The transcription of the human fructose-bisphosphate aldolase C gene is activated by nerve-growth-factor-induced B factor in human neuroblastoma cells. Buono, P., Conciliis, L.D., Izzo, P., Salvatore, F. Biochem. J. (1997) [Pubmed]
  4. Construction of rat aldolase C expression plasmid and the hybrid formation between rat aldolase C and human aldolase A or B co-expressed in Escherichia coli. Takasaki, Y., Hori, K. Protein Eng. (1990) [Pubmed]
  5. Purification of aldolase C from rat brain and hepatoma. Hatzfeld, A., Elion, J., Mennecier, F., Schapira, F. Eur. J. Biochem. (1977) [Pubmed]
  6. The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia. Dehnes, Y., Chaudhry, F.A., Ullensvang, K., Lehre, K.P., Storm-Mathisen, J., Danbolt, N.C. J. Neurosci. (1998) [Pubmed]
  7. Novel target sequences for Pax-6 in the brain-specific activating regions of the rat aldolase C gene. Skala-Rubinson, H., Vinh, J., Labas, V., Kahn, A., Phan, D.T. J. Biol. Chem. (2002) [Pubmed]
  8. Upstream elements involved in vivo in activation of the brain-specific rat aldolase C gene. Role of binding sites for POU and winged helix proteins. Skala, H., Porteu, A., Thomas, M., Szajnert, M.F., Okazawa, H., Kahn, A., Phan-Dinh-Tuy, F. J. Biol. Chem. (1998) [Pubmed]
  9. Phospholipase D2 directly interacts with aldolase via Its PH domain. Kim, J.H., Lee, S., Kim, J.H., Lee, T.G., Hirata, M., Suh, P.G., Ryu, S.H. Biochemistry (2002) [Pubmed]
  10. Histidine to aspartate phosphotransferase activity of nm23 proteins: phosphorylation of aldolase C on Asp-319. Wagner, P.D., Vu, N.D. Biochem. J. (2000) [Pubmed]
  11. The structure of the brain-specific rat aldolase C gene and its regional expression. Mukai, T., Yatsuki, H., Masuko, S., Arai, Y., Joh, K., Hori, K. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  12. Position-independent, high-level, and correct regional expression of the rat aldolase C gene in the central nervous system of transgenic mice. Arai, Y., Kajihara, S., Masuda, J., Ohishi, S., Zen, K., Ogata, J., Mukai, T. Eur. J. Biochem. (1994) [Pubmed]
  13. Molecular cloning and expression of rat aldolase C messenger RNA during development and hepatocarcinogenesis. Skala, H., Vibert, M., Lamas, E., Maire, P., Schweighoffer, F., Kahn, A. Eur. J. Biochem. (1987) [Pubmed]
  14. The first exon of the rat aldolase C gene is essential for restoring the chromatin structure in transgenic mice. Arai, Y., Sugama, T., Hashido, K., Ohishi, S., Mukai, T. J. Biochem. (1997) [Pubmed]
  15. Development of cerebellar modules: extrinsic control of late-phase zebrin II pattern and the exploration of rat/mouse species differences. Rivkin, A., Herrup, K. Mol. Cell. Neurosci. (2003) [Pubmed]
  16. Localization of aldolase C mRNA in brain cells. Popovici, T., Berwald-Netter, Y., Vibert, M., Kahn, A., Skala, H. FEBS Lett. (1990) [Pubmed]
  17. Distribution of Purkinje cell-specific Zebrin-II/aldolase C immunoreactivity in the mouse, rat, rabbit, and human retina. Caffé, A.R., Von Schantz, M., Szél, A., Voogd, J., Van Veen, T. J. Comp. Neurol. (1994) [Pubmed]
  18. Molecular, topographic, and functional organization of the cerebellar cortex: a study with combined aldolase C and olivocerebellar labeling. Sugihara, I., Shinoda, Y. J. Neurosci. (2004) [Pubmed]
  19. Selective changes in the shapes of parasagittal bands of Aldoc (Zebrin) mRNA in the rat vermis of the cerebellum after repeated methamphetamine injections. Hamamura, M., Watanabe, S., Fukumaki, Y. Cerebellum (2004) [Pubmed]
  20. Comparative proteome analysis of thalamus in MK-801-treated rats. Paulson, L., Martin, P., Nilsson, C.L., Ljung, E., Westman-Brinkmalm, A., Blennow, K., Davidsson, P. Proteomics (2004) [Pubmed]
  21. Transcriptional regulation of an aldolase gene in the regenerating rat liver. Motomura, M., Mukai, T., Ozaki, I., Joh, K., Arai, Y., Sakai, T., Hori, K. Gastroenterol. Jpn. (1990) [Pubmed]
  22. Human aldolase C gene expression is regulated by adenosine 3',5'-cyclic monophosphate (cAMP) in PC12 cells. Buono, P., Cassano, S., Alfieri, A., Mancini, A., Salvatore, F. Gene (2002) [Pubmed]
  23. Functional dissection of the brain-specific rat aldolase C gene promoter in transgenic mice. Essential role of two GC-rich boxes and an HNF3 binding site. Thomas, M., Skala, H., Kahn, A., Tuy, F.P. J. Biol. Chem. (1995) [Pubmed]
  24. Studies on the fate of aldolase molecules in the aging rat lens. Dovrat, A., Gershon, D. Biochim. Biophys. Acta (1983) [Pubmed]
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