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MeSH Review

Pia Mater

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Disease relevance of Pia Mater


High impact information on Pia Mater


Biological context of Pia Mater


Anatomical context of Pia Mater


Associations of Pia Mater with chemical compounds

  • Specific staining of beta 1 integrin-like immunoreactivity was found in the vascular structures of the brain, including microvessels, the ventricular ependymal cells, and pia mater [15].
  • RESULTS: In case of limited access to lesions adherent to the pia mater, the beta-emitter 131I provides crossfire from the CSF, resulting in a higher absorbed dose (Gy/MBq) in these lesions as compared with the Auger emitter 67Ga [16].
  • The majority of descending serotonin fibers in the white matter is located immediately below the pia mater in the ventrolateral funiculi [17].
  • Sporadic spike discharges recorded on EEGs from epidural electrodes appeared 5-10 min after topical application of 0.3 nmol delta-guanidinovaleric acid (DGVA) on the pia mater of the sensorimotor cortex, on the same side as the application [18].
  • Intraspinal serotonin fibers co-containing Leu-enkephalin were observed in the pia mater located on the most lateral surface of the spinal cord [19].

Gene context of Pia Mater

  • Pia mater in LPS-treated, but not in untreated, mouse brain showed enhanced signal for MT-I mRNA.(ABSTRACT TRUNCATED AT 400 WORDS)[20]
  • The neuronal proteins 160 kDa and 200 kDa neurofilaments, neuron-specific enolase and microtubule-associated protein 2 were, however, not immunolocalized in either the pia mater or arachnoid [21].
  • This indicates a defect in OP survival and their dorsal migration from the ventral cord region, probably because CXCR4(-/-) OP are unable to respond to CXCL12 made by vascular endothelia and the pia mater [22].
  • The signals associated with the perivascular spaces and pia mater were not blocked by unlabelled IGF-1, suggesting non-saturable binding in these brain areas [23].
  • At postnatal day 3 (P3), a strong signal representing SPARC mRNA was apparent in boundary layers such as the pia mater and the lining of the ventricles [24].

Analytical, diagnostic and therapeutic context of Pia Mater


  1. Interleukin-2 gene therapy of chronic neuropathic pain. Yao, M.Z., Gu, J.F., Wang, J.H., Sun, L.Y., Lang, M.F., Liu, J., Zhao, Z.Q., Liu, X.Y. Neuroscience (2002) [Pubmed]
  2. Increased expression of endothelial and neuronal nitric oxide synthase in dura and pia mater after air stress. Zinck, T., Illum, R., Jansen-Olesen, I. Cephalalgia : an international journal of headache. (2006) [Pubmed]
  3. Ganglionic axons in motor roots and pia mater. Hildebrand, C., Karlsson, M., Risling, M. Prog. Neurobiol. (1997) [Pubmed]
  4. Nerve growth factor induces process formation in meningeal cells: implications for scar formation in the injured CNS. Frisén, J., Risling, M., Korhonen, L., Zirrgiebel, U., Johansson, C.B., Cullheim, S., Lindholm, D. J. Neurosci. (1998) [Pubmed]
  5. Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. Hibino, H., Fujita, A., Iwai, K., Yamada, M., Kurachi, Y. J. Biol. Chem. (2004) [Pubmed]
  6. A- and B-utrophin have different expression patterns and are differentially up-regulated in mdx muscle. Weir, A.P., Burton, E.A., Harrod, G., Davies, K.E. J. Biol. Chem. (2002) [Pubmed]
  7. Progressive and transient expression of tissue plasminogen activator during fetal development. Levin, E.G., Banka, C.L., Parry, G.C. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  8. Localization of oncostatin M receptor beta in adult and developing CNS. Tamura, S., Morikawa, Y., Senba, E. Neuroscience (2003) [Pubmed]
  9. Purkinje cell expression of the mouse aldolase C gene in transgenic mice is directed by an upstream regulatory element. Romito-Digiacomo, R.R., Walther, E.U., Williams, E.A., Herrup, K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  10. Increased elastin expression in astrocytes of the lamina cribrosa in response to elevated intraocular pressure. Pena, J.D., Agapova, O., Gabelt, B.T., Levin, L.A., Lucarelli, M.J., Kaufman, P.L., Hernandez, M.R. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  11. Differential distribution of TASK-1, TASK-2 and TASK-3 immunoreactivities in the rat and human cerebellum. Rusznák, Z., Pocsai, K., Kovács, I., Pór, A., Pál, B., Bíró, T., Szücs, G. Cell. Mol. Life Sci. (2004) [Pubmed]
  12. Substance P-, calcitonin gene-related peptide, growth-associated protein-43, and neurotrophin receptor-like immunoreactivity associated with unmyelinated axons in feline ventral roots and pia mater. Risling, M., Dalsgaard, C.J., Frisén, J., Sjögren, A.M., Fried, K. J. Comp. Neurol. (1994) [Pubmed]
  13. Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat. Beuckmann, C.T., Lazarus, M., Gerashchenko, D., Mizoguchi, A., Nomura, S., Mohri, I., Uesugi, A., Kaneko, T., Mizuno, N., Hayaishi, O., Urade, Y. J. Comp. Neurol. (2000) [Pubmed]
  14. An inwardly rectifying K(+) channel, Kir4.1, expressed in astrocytes surrounds synapses and blood vessels in brain. Higashi, K., Fujita, A., Inanobe, A., Tanemoto, M., Doi, K., Kubo, T., Kurachi, Y. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  15. Anatomical localization of beta 1 integrin-like immunoreactivity in rat brain. Grooms, S.Y., Terracio, L., Jones, L.S. Exp. Neurol. (1993) [Pubmed]
  16. A dosimetric model for intrathecal treatment with 131I and 67Ga. van Dieren, E.B., van Lingen, A., Roos, J.C., Huijgens, P.C., Barendsen, G.W., Teule, G.J. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  17. Immunohistochemical study on the localization of serotonin fibers and terminals in the spinal cord of the monkey (Macaca fuscata). Kojima, M., Takeuchi, Y., Goto, M., Sano, Y. Cell Tissue Res. (1983) [Pubmed]
  18. Delta-guanidinovaleric acid as an endogenous and specific GABA-receptor antagonist: electroencephalographic study. Yokoi, I., Tsuruta, K., Shiraga, H., Mori, A., Shigara, H. Epilepsy Res. (1987) [Pubmed]
  19. Immunohistochemical examination of intraspinal serotonin neurons and fibers in the chicken lumbar spinal cord and coexistence with Leu-enkephalin. Hamada, S., Ogawa, M., Okado, N. Cell Tissue Res. (1995) [Pubmed]
  20. Constitutive expression of metallothionein genes in mouse brain. Choudhuri, S., Kramer, K.K., Berman, N.E., Dalton, T.P., Andrews, G.K., Klaassen, C.D. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  21. Absence of neuronal and glial proteins in human and rat leptomeninges in situ. Calingasan, N.Y., Bernstein, J.J., Blass, J.P. J. Neurol. Sci. (1996) [Pubmed]
  22. A role for CXCR4 signaling in survival and migration of neural and oligodendrocyte precursors. Dziembowska, M., Tham, T.N., Lau, P., Vitry, S., Lazarini, F., Dubois-Dalcq, M. Glia (2005) [Pubmed]
  23. Intracerebral transportation and cellular localisation of insulin-like growth factor-1 following central administration to rats with hypoxic-ischemic brain injury. Guan, J., Beilharz, E.J., Skinner, S.J., Williams, C.E., Gluckman, P.D. Brain Res. (2000) [Pubmed]
  24. Expression of the gene encoding the extracellular matrix glycoprotein SPARC in the developing and adult mouse brain. Mendis, D.B., Brown, I.R. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  25. Developmental regulation of decorin expression in postnatal rat brain. Kappler, J., Stichel, C.C., Gleichmann, M., Gillen, C., Junghans, U., Kresse, H., Müller, H.W. Brain Res. (1998) [Pubmed]
  26. Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum. Ueda, H., Baba, T., Terada, N., Kato, Y., Fujii, Y., Takayama, I., Mei, X., Ohno, S. Neurosci. Lett. (2000) [Pubmed]
  27. Ultrastructural observations of astrocyte end-feet in the rat central nervous system. Nakazawa, E., Ishikawa, H. J. Neurocytol. (1998) [Pubmed]
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