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Gene Review

Cuzd1  -  CUB and zona pellucida-like domains 1

Rattus norvegicus

Synonyms: CUB and ZP domain-containing protein 1, CUB and zona pellucida-like domain-containing protein 1, ERG1, Erg1, Estrogen-regulated protein 1, ...
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Disease relevance of Cuzd1


High impact information on Cuzd1


Biological context of Cuzd1

  • Nucleotide sequence analysis of the full-length ERG1 cDNA indicates that it has an open reading frame of 1821 nuceotides encoding a putative protein of 607 amino acids with a single transmembrane domain and a short cytoplasmic tail [11].
  • This estrogen-regulated enkephalinergic cell group may represent part of the neural network mediating estrogen's effects on reproductive behavior and/or other neuroendocrine processes [12].
  • The kinetics of increase in estrogen-regulated messages was examined [13].
  • Rat erg1 currents recorded in the cell-attached configuration were reduced by application of TRH to the extra-patch membrane in the majority of the experiments, confirming the involvement of a diffusible second messenger [14].
  • Estrogen regulated twice as many genes as Ral, largely those associated with catalysis and metabolism, whereas Ral induced genes associated with cell death and negative cell regulation [15].

Anatomical context of Cuzd1

  • Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1) [11].
  • Spatio-temporal analyses reveal that ERG1 mRNA is expressed in a highly stage-specific manner in the uterus and oviduct, and its expression is restricted to the surface epithelium of both of these tissues [11].
  • Estrogen-regulated synthesis of neurotensin in neurosecretory cells of the hypothalamic arcuate nucleus in the female rat [16].
  • NR-ISH experiments detected transcripts encoded by all three ERG genes in the cerebral cortex and in all CA subfields and in the granular cell layer of the dentate gyrus of the hippocampus; strong ERG1 signals were also detected in scattered large elements throughout the oriens, pyramidal, and radiatum layers, and in the hilus of the dentate gyrus [17].
  • Finally, ERG1 expression was also revealed in non-neuronal elements such as ependymal and subependymal cells along the ventricular walls and hippocampal astrocytes [17].

Associations of Cuzd1 with chemical compounds


Regulatory relationships of Cuzd1


Other interactions of Cuzd1


Analytical, diagnostic and therapeutic context of Cuzd1

  • To further our hypothesis that thrombin is an estrogen-regulated uterine growth factor, we used immunohistochemistry, Western blotting, and coagulation assays to localize the cell types in which these proteins are increased by estradiol [26].
  • Two of these estrogen-regulated genes, designated ARG-33 and ARG-40, were further characterized using Northern blot hybridizations [27].
  • The expression of two estrogen-regulated early response genes c-fos and vascular endothelial growth factor (VEGF), and DNA synthesis were analysed at 1-24 h after treatment of ovariectomized rats [28].
  • This differential expression had also been confirmed by in situ hybridization, which showed that ERG1 mRNA was down-regulated in the dorsal dentate granule cells (dDGCs) of the hippocampal formation, but remarkable up-regulated in the amygdalohippocampal area (AHi), posteromedial cortical amygdaloid nucleus (PMCo) and perirhinal cortex (PRh) [21].
  • Sequence analysis revealed that ERG1 has high sequence similarity with the cDNA of the Mus musculus suppressor of K(+) transport growth defect (SKD2), N-ethylmaleimide(NEM)-sensitive fusion protein of Chinese hamster and human NEM-sensitive factor (HSU03985) [21].


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  2. Correlation between low levels of estrogen receptors and estrogen responsiveness in two rat osteoblast-like cell lines. Davis, V.L., Couse, J.F., Gray, T.K., Korach, K.S. J. Bone Miner. Res. (1994) [Pubmed]
  3. The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium. Tynan, S., Pacia, E., Haynes-Johnson, D., Lawrence, D., D'Andrea, M.R., Guo, J.Z., Lundeen, S., Allan, G. Endocrinology (2005) [Pubmed]
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  5. Identification of estrogen regulated genes in Fe33 rat hepatoma cells by differential display polymerase chain reaction and their hormonal regulation in rat liver and uterus. Diel, P., Walter, A., Fritzemeier, K.H., Hegele-Hartung, C., Knauthe, R. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
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  8. Cloning of a novel receptor expressed in rat prostate and ovary. Kuiper, G.G., Enmark, E., Pelto-Huikko, M., Nilsson, S., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  9. Selective inhibition of estrogen-regulated gene expression in vivo by the pure antiestrogen ICI 182,780. Hyder, S.M., Chiappetta, C., Murthy, L., Stancel, G.M. Cancer Res. (1997) [Pubmed]
  10. In vivo regulation of syndecan-3 expression in the rat uterus by 17 beta-estradiol. Russo, L.A., Calabro, S.P., Filler, T.A., Carey, D.J., Gardner, R.M. J. Biol. Chem. (2001) [Pubmed]
  11. Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1). Chen, D., Xu, X., Zhu, L.J., Angervo, M., Li, Q., Bagchi, M.K., Bagchi, I.C. J. Biol. Chem. (1999) [Pubmed]
  12. Estrogen increases proenkephalin messenger ribonucleic acid levels in the ventromedial hypothalamus of the rat. Romano, G.J., Harlan, R.E., Shivers, B.D., Howells, R.D., Pfaff, D.W. Mol. Endocrinol. (1988) [Pubmed]
  13. Cloning of estrogen-regulated messenger ribonucleic acids from rat uterus. Hsu, C.Y., Komm, B.S., Lyttle, C.R., Frankel, F. Endocrinology (1988) [Pubmed]
  14. Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin-releasing hormone in anterior pituitary cells via the native signal cascade. Schledermann, W., Wulfsen, I., Schwarz, J.R., Bauer, C.K. J. Physiol. (Lond.) (2001) [Pubmed]
  15. Differential effects of estrogen and raloxifene on messenger RNA and matrix metalloproteinase 2 activity in the rat uterus. Helvering, L.M., Adrian, M.D., Geiser, A.G., Estrem, S.T., Wei, T., Huang, S., Chen, P., Dow, E.R., Calley, J.N., Dodge, J.A., Grese, T.A., Jones, S.A., Halladay, D.L., Miles, R.R., Onyia, J.E., Ma, Y.L., Sato, M., Bryant, H.U. Biol. Reprod. (2005) [Pubmed]
  16. Estrogen-regulated synthesis of neurotensin in neurosecretory cells of the hypothalamic arcuate nucleus in the female rat. Alexander, M.J. Endocrinology (1993) [Pubmed]
  17. Expression pattern of the ether-a-gogo-related (ERG) K+ channel-encoding genes ERG1, ERG2, and ERG3 in the adult rat central nervous system. Papa, M., Boscia, F., Canitano, A., Castaldo, P., Sellitti, S., Annunziato, L., Taglialatela, M. J. Comp. Neurol. (2003) [Pubmed]
  18. Regulation and ligand-binding specificities of two sex-specific bile acid-binding proteins of rat liver cytosol. LeBlanc, G.A., Waxman, D.J. J. Biol. Chem. (1990) [Pubmed]
  19. Estradiol stimulates a uterine plasma membrane protease activator. Jazín, E.E., Dickerman, H.W., Henrikson, K.P. Endocrinology (1988) [Pubmed]
  20. Characterization of a uterine luminal fluid protein ULF-250 using N-terminal microsequencing and RT-PCR identifies a novel estrogen-regulated gene in the rat uterus. Kumar G, P., Laloraya, M., Koide, S.S. FEBS Lett. (1996) [Pubmed]
  21. A spontaneous recurrent seizure-related Rattus NSF gene identified by linker capture subtraction. Guan, Z., Lu, L., Zheng, Z., Liu, J., Yu, F., Lü, S., Xin, Y., Liu, X., Hong, J., Zhang, W. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  22. The low-density lipoprotein receptor is regulated by estrogen and forms a functional complex with the estrogen-regulated protein ezrin in pituitary GH3 somatolactotropes. Smith, P.M., Cowan, A., White, B.A. Endocrinology (2004) [Pubmed]
  23. Estrogen-modulated estrogen receptor x Pit-1 protein complex formation and prolactin gene activation require novel protein synthesis. Ying, C., Lin, D.H. J. Biol. Chem. (2000) [Pubmed]
  24. Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female rat. Naciff, J.M., Overmann, G.J., Torontali, S.M., Carr, G.J., Tiesman, J.P., Daston, G.P. Environ. Health Perspect. (2004) [Pubmed]
  25. Ontogeny, sex dimorphism, and neonatal sex hormone determination of synapse-associated messenger RNAs in rat brain. Lustig, R.H., Hua, P., Wilson, M.C., Federoff, H.J. Brain Res. Mol. Brain Res. (1993) [Pubmed]
  26. Cellular localization of tissue factor and prothrombin in the estrogen-treated immature rat uterus. Henrikson, K.P., Hall, E.S., Lin, Y. Biol. Reprod. (1994) [Pubmed]
  27. Isolation of differentially expressed mRNA in ovaries after estrogen withdrawal in hypophysectomized diethylstilbestrol-treated rats: increased expression during apoptosis. Svanberg, B., Billig, H. J. Endocrinol. (1999) [Pubmed]
  28. Comparative study of the short-term effects of a novel selective estrogen receptor modulator, ospemifene, and raloxifene and tamoxifen on rat uterus. Zheng, H., Kangas, L., Härkönen, P.L. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
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