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Gene Review

Sdc3  -  syndecan 3

Rattus norvegicus

Synonyms: N-syndecan, Neuroglycan, SYND3, Synd3, Syndecan-3
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High impact information on Sdc3

  • Our hypothesis that HB-GAM/N-syndecan interaction participates in regulation of osteoblast recruitment was tested using two different in vivo models: an adjuvant-induced arthritic model and a transgenic model [1].
  • In the adjuvant-induced injury model, the expression of HB-GAM and of N-syndecan is strongly upregulated in the periosteum accompanying the regenerative response of bone [1].
  • Intriguingly, N-syndecan, which acts as a receptor for HB-GAM, is expressed by osteoblasts/osteoblast precursors, whose ultrastructural phenotypes suggest active cell motility [1].
  • Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan [2].
  • N-syndecan may thus act as an important regulator in the activity-dependent modulation of neuronal connectivity by transmitting signals between extracellular heparin-binding factors and the fyn signaling pathway [3].

Biological context of Sdc3


Anatomical context of Sdc3


Associations of Sdc3 with chemical compounds


Regulatory relationships of Sdc3


Other interactions of Sdc3


Analytical, diagnostic and therapeutic context of Sdc3


  1. Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM). Imai, S., Kaksonen, M., Raulo, E., Kinnunen, T., Fages, C., Meng, X., Lakso, M., Rauvala, H. J. Cell Biol. (1998) [Pubmed]
  2. Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan. Carey, D.J., Evans, D.M., Stahl, R.C., Asundi, V.K., Conner, K.J., Garbes, P., Cizmeci-Smith, G. J. Cell Biol. (1992) [Pubmed]
  3. Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation. Lauri, S.E., Kaukinen, S., Kinnunen, T., Ylinen, A., Imai, S., Kaila, K., Taira, T., Rauvala, H. J. Neurosci. (1999) [Pubmed]
  4. cDNA cloning, genomic organization, and in vivo expression of rat N-syndecan. Carey, D.J., Conner, K., Asundi, V.K., O'Mahony, D.J., Stahl, R.C., Showalter, L., Cizmeci-Smith, G., Hartman, J., Rothblum, L.I. J. Biol. Chem. (1997) [Pubmed]
  5. Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. Kinnunen, T., Kaksonen, M., Saarinen, J., Kalkkinen, N., Peng, H.B., Rauvala, H. J. Biol. Chem. (1998) [Pubmed]
  6. Pleiotrophin mediates the neurotrophic effect of cyclic AMP on dopaminergic neurons: analysis of suppression-subtracted cDNA libraries and confirmation in vitro. Mourlevat, S., Debeir, T., Ferrario, J.E., Delbe, J., Caruelle, D., Lejeune, O., Depienne, C., Courty, J., Raisman-Vozari, R., Ruberg, M. Exp. Neurol. (2005) [Pubmed]
  7. Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface. Kinnunen, T., Raulo, E., Nolo, R., Maccarana, M., Lindahl, U., Rauvala, H. J. Biol. Chem. (1996) [Pubmed]
  8. Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. Asahina, K., Sato, H., Yamasaki, C., Kataoka, M., Shiokawa, M., Katayama, S., Tateno, C., Yoshizato, K. Am. J. Pathol. (2002) [Pubmed]
  9. Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility. Rauvala, H., Huttunen, H.J., Fages, C., Kaksonen, M., Kinnunen, T., Imai, S., Raulo, E., Kilpeläinen, I. Matrix Biol. (2000) [Pubmed]
  10. Heparan sulphate and HB-GAM (heparin-binding growth-associated molecule) in the development of the thalamocortical pathway of rat brain. Kinnunen, A., Niemi, M., Kinnunen, T., Kaksonen, M., Nolo, R., Rauvala, H. Eur. J. Neurosci. (1999) [Pubmed]
  11. N-syndecan and HB-GAM (heparin-binding growth-associated molecule) associate with early axonal tracts in the rat brain. Kinnunen, A., Kinnunen, T., Kaksonen, M., Nolo, R., Panula, P., Rauvala, H. Eur. J. Neurosci. (1998) [Pubmed]
  12. Co-expression of heparin-binding growth-associated molecule (HB-GAM) and N-syndecan (syndecan-3) in developing rat brain. Nolo, R., Kaksonen, M., Raulo, E., Rauvala, H. Neurosci. Lett. (1995) [Pubmed]
  13. Matrix metalloproteinase-dependent shedding of syndecan-3, a transmembrane heparan sulfate proteoglycan, in Schwann cells. Asundi, V.K., Erdman, R., Stahl, R.C., Carey, D.J. J. Neurosci. Res. (2003) [Pubmed]
  14. Syndecan-3 and perlecan are differentially expressed by progenitors and mature oligodendrocytes and accumulate in the extracellular matrix. Winkler, S., Stahl, R.C., Carey, D.J., Bansal, R. J. Neurosci. Res. (2002) [Pubmed]
  15. In vivo regulation of syndecan-3 expression in the rat uterus by 17 beta-estradiol. Russo, L.A., Calabro, S.P., Filler, T.A., Carey, D.J., Gardner, R.M. J. Biol. Chem. (2001) [Pubmed]
  16. Syndecan-4 is a primary-response gene induced by basic fibroblast growth factor and arterial injury in vascular smooth muscle cells. Cizmeci-Smith, G., Langan, E., Youkey, J., Showalter, L.J., Carey, D.J. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  17. Regulation of mRNA localization by transmembrane signalling: local interaction of HB-GAM (heparin-binding growth-associated molecule) with the cell surface localizes beta-actin mRNA. Fages, C., Kaksonen, M., Kinnunen, T., Punnonen, E.L., Rauvala, H. J. Cell. Sci. (1998) [Pubmed]
  18. Spatiotemporal expression patterns of N-syndecan, a transmembrane heparan sulfate proteoglycan, in developing retina. Inatani, M., Honjo, M., Oohira, A., Kido, N., Otori, Y., Tano, Y., Honda, Y., Tanihara, H. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
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