Gene Review:
Ldlr - low density lipoprotein receptor
Rattus norvegicus
Synonyms:
LDL receptor, Low-density lipoprotein receptor
- Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia. Pallottini, V., Martini, C., Cavallini, G., Donati, A., Bergamini, E., Notarnicola, M., Caruso, M.G., Trentalance, A. J. Cell. Biochem. (2006)
- Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. Hinagata, J., Kakutani, M., Fujii, T., Naruko, T., Inoue, N., Fujita, Y., Mehta, J.L., Ueda, M., Sawamura, T. Cardiovasc. Res. (2006)
- Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex. Orlando, R.A., Farquhar, M.G. Proc. Natl. Acad. Sci. U.S.A. (1993)
- An antibody fragment from a phage display library competes for ligand binding to the low density lipoprotein receptor family and inhibits rhinovirus infection. Hodits, R.A., Nimpf, J., Pfistermueller, D.M., Hiesberger, T., Schneider, W.J., Vaughan, T.J., Johnson, K.S., Haumer, M., Kuechler, E., Winter, G. J. Biol. Chem. (1995)
- Estrogen replacement during hypoalbuminemia may enhance atherosclerotic risk. Joles, J.A., Bijleveld, C., van Tol, A., Geelen, M.J., Koomans, H.A. J. Am. Soc. Nephrol. (1997)
- Serum deprivation increases the expression of low density lipoprotein receptor-related protein in primary cultured rat astrocytes. Jo, I., Im, H.M., Shin, H.J., Won Cho, K., Jung, M., Kim, S.D., Kim Jeong, J., Ahn Jo, S. Biochem. Biophys. Res. Commun. (2002)
- Basolateral sorting in MDCK cells requires a distinct cytoplasmic domain determinant. Hunziker, W., Harter, C., Matter, K., Mellman, I. Cell (1991)
- Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Poirier, J. Trends Neurosci. (1994)
- Growth hormone and bile acid synthesis. Key role for the activity of hepatic microsomal cholesterol 7alpha-hydroxylase in the rat. Rudling, M., Parini, P., Angelin, B. J. Clin. Invest. (1997)
- Regulation of rat hepatic low density lipoprotein receptors. In vivo stimulation by growth hormone is not mediated by insulin-like growth factor I. Rudling, M., Olivecrona, H., Eggertsen, G., Angelin, B. J. Clin. Invest. (1996)
- Stimulation of rat hepatic low density lipoprotein receptors by glucagon. Evidence of a novel regulatory mechanism in vivo. Rudling, M., Angelin, B. J. Clin. Invest. (1993)
- Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia. Shin, Y., Vaziri, N.D., Willekes, N., Kim, C.H., Joles, J.A. Am. J. Physiol. Endocrinol. Metab. (2005)
- Amiodarone-induced hypercholesterolemia is associated with a decrease in liver LDL receptor mRNA. Hudig, F., Bakker, O., Wiersinga, W.M. FEBS Lett. (1994)
- Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats. Ness, G.C., Zhao, Z. Arch. Biochem. Biophys. (1994)
- Nucleotide sequence of the rat low density lipoprotein receptor cDNA. Lee, L.Y., Mohler, W.A., Schafer, B.L., Freudenberger, J.S., Byrne-Connolly, N., Eager, K.B., Mosley, S.T., Leighton, J.K., Thrift, R.N., Davis, R.A. Nucleic Acids Res. (1989)
- Structure of the hamster low density lipoprotein receptor gene. Bishop, R.W. J. Lipid Res. (1992)
- Dietary fish oil stimulates hepatic low density lipoprotein transport in the rat. Ventura, M.A., Woollett, L.A., Spady, D.K. J. Clin. Invest. (1989)
- Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes. Rapp, A., Gmeiner, B., Hüttinger, M. Biochimie (2006)
- Association of the low-density lipoprotein receptor with caveolae in hamster and rat liver. Ness, G.C., Kohlruss, N., Gertz, K.R. Biochem. Biophys. Res. Commun. (2003)
- Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo. Choi, S.Y., Fong, L.G., Kirven, M.J., Cooper, A.D. J. Clin. Invest. (1991)
- A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. Boyles, J.K., Zoellner, C.D., Anderson, L.J., Kosik, L.M., Pitas, R.E., Weisgraber, K.H., Hui, D.Y., Mahley, R.W., Gebicke-Haerter, P.J., Ignatius, M.J. J. Clin. Invest. (1989)
- The low-density lipoprotein receptor is regulated by estrogen and forms a functional complex with the estrogen-regulated protein ezrin in pituitary GH3 somatolactotropes. Smith, P.M., Cowan, A., White, B.A. Endocrinology (2004)
- A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. Chen, C.W., Cheng, H.H. J. Nutr. (2006)
- Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. Lopez, J.M., Bennett, M.K., Sanchez, H.B., Rosenfeld, J.M., Osborne, T.E. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Differences in the mechanisms of uptake and endocytosis of small and large chylomicron remnants by rat liver. Windler, E., Greeve, J., Robenek, H., Rinninger, F., Greten, H., Jäckle, S. Hepatology (1996)
- Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction. Stolt, P.C., Chen, Y., Liu, P., Bock, H.H., Blacklow, S.C., Herz, J. J. Biol. Chem. (2005)
- Chylomicron remnants: hepatic receptors and metabolism. Havel, R.J. Curr. Opin. Lipidol. (1995)
- Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter. Magaña, M.M., Osborne, T.F. J. Biol. Chem. (1996)
- Glucagon, cyclic AMP and adrenaline stimulate the degradation of low-density lipoprotein by cultured rat hepatocytes. Brown, N.F., Salter, A.M., Fears, R., Brindley, D.N. Biochem. J. (1989)
- Activation of IP(3)-protein kinase C-alpha signal transduction pathway precedes the changes of plasma cholesterol, hepatic lipid metabolism and induction of low-density lipoprotein receptor expression in 17-beta-oestradiol-treated rats. Marino, M., Distefano, E., Pallottini, V., Caporali, S., Bruscalupi, G., Trentalance, A. Exp. Physiol. (2001)
- Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE. Chen, M., Nagase, M., Fujita, T., Narumiya, S., Masaki, T., Sawamura, T. Biochem. Biophys. Res. Commun. (2001)
- Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. Chen, Y.T., Stewart, D.B., Nelson, W.J. J. Cell Biol. (1999)
- The role of plasminogen activator inhibitor type 1 in the clearance of tissue-type plasminogen activator by rat hepatoma cells. Camani, C., Bachmann, F., Kruithof, E.K. J. Biol. Chem. (1994)
- Loss of resistance to dietary cholesterol in the rat after hypophysectomy: importance of the presence of growth hormone for hepatic low density lipoprotein-receptor expression. Rudling, M., Angelin, B. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor-avidin fusion protein. Lehtolainen, P., Wirth, T., Taskinen, A.K., Lehenkari, P., Leppänen, O., Lappalainen, M., Pulkkanen, K., Marttila, A., Marjomäki, V., Airenne, K.J., Horton, M., Kulomaa, M.S., Ylä-Herttuala, S. Gene Ther. (2003)
- Regulation of cholesterol metabolism in the ethionine-induced premalignant rat liver. Erickson, S.K., Lear, S.R., Barker, M.E., Musliner, T.A. J. Lipid Res. (1990)
- Early induction of LDL receptor gene during rat liver regeneration. Bocchetta, M., Bruscalupi, G., Castellano, F., Trentalance, A., Komaromy, M., Fong, L.G., Cooper, A.D. J. Cell. Physiol. (1993)
- Endotoxin suppresses rat hepatic low-density lipoprotein receptor expression. Liao, W., Rudling, M., Angelin, B. Biochem. J. (1996)