The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ANXA7  -  annexin A7

Homo sapiens

Synonyms: ANX7, Annexin A7, Annexin VII, Annexin-7, OK/SW-cl.95, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ANXA7

  • These include the first single-domain, bacterial annexin in Cytophaga hutchinsonii, the 21 tetrad annexins from the unicellular protist Giardia intestinalis, an ancestor to land plant annexins from the green alga Ostreococcus lucimarinus, invertebrate octad annexins and a critical polymorphism in human ANXA7 [1].
  • We conclude that the ANX7 gene exhibits many biological and genetic properties expected of a TSG and may play a role in prostate cancer progression [2].
  • An in vitro study of astrocyte-derived C6 rat glioblastoma cells expressing a GFP tagged annexin VII fusion protein demonstrates a sequential redistribution of the fusion protein in response to rising intracellular Ca2+ concentrations [3].
  • HIV-1 Gag shares a signature motif with annexin (Anx7), which is required for virus replication [4].
  • CONCLUSIONS: High levels of ANX7 in tumor correlate strongly with poor survival of HER2-negative patients and the most aggressive forms of breast cancer [5].

High impact information on ANXA7


Chemical compound and disease context of ANXA7


Biological context of ANXA7

  • 4. Overlay assays using deletion constructs of the synexin N-terminal domain mapped the sorcin binding site to the N-terminal 31 amino acids of the synexin protein [8].
  • Furthermore, synexin down-regulation abolished anti-apoptotic activity of galectin-3 [9].
  • Taken together, these results suggest that synexin mediates galectin-3 translocation to the perinuclear mitochondrial membranes, where it regulates mitochondrial integrity critical for apoptosis regulation [9].
  • Thus, ANXA7 and p53 can distinctly regulate LOX transcription that is potentially relevant to the AA-mediated cell growth control in tumor suppression [7].
  • Synexin is a calcium-dependent membrane binding protein that not only fuses membranes but also acts as a voltage-dependent calcium channel [10].

Anatomical context of ANXA7


Associations of ANXA7 with chemical compounds


Other interactions of ANXA7


Analytical, diagnostic and therapeutic context of ANXA7

  • Both in undifferentiated and differentiated cells annexin VII was localized by immunofluorescence microscopy to punctate structures which were distributed all over the cell [11].
  • We have analyzed 90 degree light scattering data to determine a titration curve for the activation of synexin by Ca2+ in the self-association reaction [17].
  • Electron microscopy of negatively stained samples reveals that synexin monomers associate to form 50 A by 150 A rods which in turn associate side to side and end to end to form bundles of parallel rods [17].
  • After subtotal nephrectomy protein excretion SNX (130.0 +/- 22.5 mg/24 h) was increased in comparison to the ET(A)-group (446 +/- 103 mg/24 h) and the ET(AB)-group (23.2 +/- 37 mg/24 h) vs sham: 115 +/- 19 mg/24 h) [18].
  • SNX is attached to genomic DNA with a simultaneous ligation/restriction reaction that is highly efficient and improves recovery of sequences after subtractive hybridization [19].


  1. Deciphering function and mechanism of calcium-binding proteins from their evolutionary imprints. Morgan, R.O., Martin-Almedina, S., Garcia, M., Jhoncon-Kooyip, J., Fernandez, M.P. Biochim. Biophys. Acta (2006) [Pubmed]
  2. ANX7, a candidate tumor suppressor gene for prostate cancer. Srivastava, M., Bubendorf, L., Srikantan, V., Fossom, L., Nolan, L., Glasman, M., Leighton, X., Fehrle, W., Pittaluga, S., Raffeld, M., Koivisto, P., Willi, N., Gasser, T.C., Kononen, J., Sauter, G., Kallioniemi, O.P., Srivastava, S., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Annexin VII: an astroglial protein exhibiting a Ca2+-dependent subcellular distribution. Clemen, C.S., Herr, C., Lie, A.A., Noegel, A.A., Schröder, R. Neuroreport (2001) [Pubmed]
  4. HIV-1 Gag shares a signature motif with annexin (Anx7), which is required for virus replication. Srivastava, M., Cartas, M., Rizvi, T.A., Singh, S.P., Serio, D., Kalyanaraman, V.S., Pollard, H.B., Srinivasan, A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Prognostic impact of ANX7-GTPase in metastatic and HER2-negative breast cancer patients. Srivastava, M., Bubendorf, L., Raffeld, M., Bucher, C., Torhorst, J., Sauter, G., Olsen, C., Kallioniemi, O.P., Eidelman, O., Pollard, H.B. Clin. Cancer Res. (2004) [Pubmed]
  6. Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse. Srivastava, M., Montagna, C., Leighton, X., Glasman, M., Naga, S., Eidelman, O., Ried, T., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Distinct Effects of Annexin A7 and p53 on Arachidonate Lipoxygenation in Prostate Cancer Cells Involve 5-Lipoxygenase Transcription. Torosyan, Y., Dobi, A., Naga, S., Mezhevaya, K., Glasman, M., Norris, C., Jiang, G., Mueller, G., Pollard, H., Srivastava, M. Cancer Res. (2006) [Pubmed]
  8. Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). Brownawell, A.M., Creutz, C.E. J. Biol. Chem. (1997) [Pubmed]
  9. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation. Yu, F., Finley, R.L., Raz, A., Kim, H.R. J. Biol. Chem. (2002) [Pubmed]
  10. Calcium channel activity of purified human synexin and structure of the human synexin gene. Burns, A.L., Magendzo, K., Shirvan, A., Srivastava, M., Rojas, E., Alijani, M.R., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  11. Expression and localisation of annexin VII (synexin) isoforms in differentiating myoblasts. Clemen, C.S., Hofmann, A., Zamparelli, C., Noegel, A.A. J. Muscle Res. Cell. Motil. (1999) [Pubmed]
  12. Calcium-activated endonexin II forms calcium channels across acidic phospholipid bilayer membranes. Rojas, E., Pollard, H.B., Haigler, H.T., Parra, C., Burns, A.L. J. Biol. Chem. (1990) [Pubmed]
  13. Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin. Salzer, U., Hinterdorfer, P., Hunger, U., Borken, C., Prohaska, R. Blood (2002) [Pubmed]
  14. Divergent structure of the human synexin (annexin VII) gene and assignment to chromosome 10. Shirvan, A., Srivastava, M., Wang, M.G., Cultraro, C., Magendzo, K., McBride, O.W., Pollard, H.B., Burns, A.L. Biochemistry (1994) [Pubmed]
  15. Calcium-dependent binding of the plasma protein apolipoprotein A-I to two members of the annexin family. Brownawell, A.M., Creutz, C.E. Biochemistry (1996) [Pubmed]
  16. Voltage dependent binding of annexin V, annexin VI and annexin VII-core to acidic phospholipid membranes. Hofmann, A., Benz, J., Liemann, S., Huber, R. Biochim. Biophys. Acta (1997) [Pubmed]
  17. Self-association of synexin in the presence of calcium. Correlation with synexin-induced membrane fusion and examination of the structure of synexin aggregates. Creutz, C.E., Pazoles, C.J., Pollard, H.B. J. Biol. Chem. (1979) [Pubmed]
  18. Endothelin-receptor antagonists in uremic cardiomyopathy. Wolf, S.C., Gaschler, F., Brehm, S., Klaussner, M., Amann, K., Risler, T., Brehm, B.R. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  19. Universal linker and ligation procedures for construction of genomic DNA libraries enriched for microsatellites. Hamilton, M.B., Pincus, E.L., Di Fiore, A., Fleischer, R.C. BioTechniques (1999) [Pubmed]
WikiGenes - Universities