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Gene Review

Asgr1  -  asialoglycoprotein receptor 1

Mus musculus

Synonyms: ASGP-R 1, ASGPR 1, ASGPR1, Asgr, Asgr-1, ...
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Disease relevance of Asgr1


High impact information on Asgr1


Biological context of Asgr1


Anatomical context of Asgr1

  • PVLA-coated beads bound to and were endocytosed by the whole (MHL-1/-2) ASGP receptor-expressing CHO cells like hepatocytes while PVMA (poly-(N-p-vinylbenzyl-O-beta-D-glucopyranosyl-[1-4]-D-gluconamide) did not [15].
  • In summary, we have prepared a nontoxic cell-specific lysosome disruptive element that improves gene delivery to parenchymal liver cells via the ASGPr [13].
  • Simple sugars with affinity for the macrophage asialoglycoprotein receptor are adjuvants for the humoral immune response to neuraminidase-treated sheep erythrocytes [16].
  • We now have investigated this possible alternative route of infection for SV wild-type (SV-wt) strain Fushimi by using a pair of cell lines which differ only with regard to ASGP-R expression [1].
  • Similarly, in NIH 3T3 cells singly transfected with the ASGP-R H2a subunit cDNA, ALLN inhibited degradation of the ASGP-R H2a subunit precursor, as well as the degradation of the 35 kDa proteolytic fragment corresponding to the receptor ectodomain, by 3-6-fold [17].

Associations of Asgr1 with chemical compounds

  • Serum concentrations of galactose-terminating glycoproteins are not elevated in these ASGPR-deficient mice [10].
  • Thereby, the mouse asialoglycoprotein receptor apparently possesses additional binding pockets that accommodate a fucose residue when presented as Le(x) [18].
  • Here too, we synthesized a novel glycolipid, which possesses a highly hydrophobic steroid moiety for stable incorporation into liposomes, and a triantennary GalNAc(3)-terminated cluster glycoside with a high nanomolar affinity (2 nm) for the ASGPr [19].
  • In addition, the lysine epsilon-amino groups were covalently bound to galactose (galactosyl-PLSP), a ligand for the asialoglycoprotein receptor on hepatocytes [20].
  • Overall, our data suggest the involvement of cysteine proteinases located in the endoplasmic reticulum, as well as in post-Golgi compartments, in degradation of the EPO-R and the ASGP-R H2a subunit [17].

Other interactions of Asgr1


Analytical, diagnostic and therapeutic context of Asgr1


  1. Sendai virus efficiently infects cells via the asialoglycoprotein receptor and requires the presence of cleaved F0 precursor proteins for this alternative route of cell entry. Bitzer, M., Lauer, U., Baumann, C., Spiegel, M., Gregor, M., Neubert, W.J. J. Virol. (1997) [Pubmed]
  2. Inhibition of blood clearance and hepatic tissue binding of Escherichia coli by liver lectin-specific sugars and glycoproteins. Perry, A., Ofek, I. Infect. Immun. (1984) [Pubmed]
  3. Hepatitis B surface protein docked vesicular carrier for site specific delivery to liver. Khatri, K., Rawat, A., Mahor, S., Gupta, P.N., Vyas, S.P. Journal of drug targeting. (2005) [Pubmed]
  4. Toxic ligand conjugates as tools in the study of receptor-ligand interactions. Herschman, H.R., Simpson, D.L., Cawley, D.B. J. Cell. Biochem. (1982) [Pubmed]
  5. Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan. Beuth, J., Ko, H.L., Schirrmacher, V., Uhlenbruck, G., Pulverer, G. Clin. Exp. Metastasis (1988) [Pubmed]
  6. Biodistribution of antibodies after intraperitoneal or intravenous injection and effect of carbohydrate modifications. Mattes, M.J. J. Natl. Cancer Inst. (1987) [Pubmed]
  7. Two pathways for the degradation of the H2 subunit of the asialoglycoprotein receptor in the endoplasmic reticulum. Yuk, M.H., Lodish, H.F. J. Cell Biol. (1993) [Pubmed]
  8. Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits. Fuhrer, C., Geffen, I., Spiess, M. J. Cell Biol. (1991) [Pubmed]
  9. The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acid alpha 2,6GalNAc. Park, E.I., Mi, Y., Unverzagt, C., Gabius, H.J., Baenziger, J.U. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit. Braun, J.R., Willnow, T.E., Ishibashi, S., Ashwell, G., Herz, J. J. Biol. Chem. (1996) [Pubmed]
  11. Assignment of Amog (adhesion molecule on glia) gene to mouse chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17. Hsieh, C.L., Cheng-Deutsch, A., Gloor, S., Schachner, M., Francke, U. Somat. Cell Mol. Genet. (1990) [Pubmed]
  12. Asialoglycoprotein receptor expression in murine pregnancy and development. Collins, J.C., Stockert, R.J., Morell, A.G. Hepatology (1984) [Pubmed]
  13. Targeted lysosome disruptive elements for improvement of parenchymal liver cell-specific gene delivery. Van Rossenberg, S.M., Sliedregt-Bol, K.M., Meeuwenoord, N.J., Van Berkel, T.J., Van Boom, J.H., Van Der Marel, G.A., Biessen, E.A. J. Biol. Chem. (2002) [Pubmed]
  14. Impaired receptor-mediated endocytosis by the asialoglycoprotein receptor in ethanol-fed mice: implications for studying the role of this receptor in alcoholic apoptosis. Dalton, S.R., Wiegert, R.L., Baldwin, C.R., Kassel, K.M., Casey, C.A. Biochem. Pharmacol. (2003) [Pubmed]
  15. Functional evaluation of poly-(N-p-vinylbenzyl-O-beta-D-galactopyranosyl-[1-4]-D-gluconamide)(PVLA) as a liver specific carrier. Watanabe, Y., Liu, X., Shibuya, I., Akaike, T. Journal of biomaterials science. Polymer edition. (2000) [Pubmed]
  16. Simple sugars with affinity for the macrophage asialoglycoprotein receptor are adjuvants for the humoral immune response to neuraminidase-treated sheep erythrocytes. Klerx, J.P., Molendijk, A.J., Van Dijk, H., Vloet, K.P., Willers, J.M. J. Immunol. (1986) [Pubmed]
  17. Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms. Neumann, D., Yuk, M.H., Lodish, H.F., Lederkremer, G.Z. Biochem. J. (1996) [Pubmed]
  18. Tissue targeting of multivalent Le(x)-terminated N-linked oligosaccharides in mice. Chiu, M.H., Thomas, V.H., Stubbs, H.J., Rice, K.G. J. Biol. Chem. (1995) [Pubmed]
  19. Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo. Rensen, P.C., Sliedregt, L.A., Ferns, M., Kieviet, E., van Rossenberg, S.M., van Leeuwen, S.H., van Berkel, T.J., Biessen, E.A. J. Biol. Chem. (2001) [Pubmed]
  20. In vivo targeted gene transfer into liver cells mediated by a novel galactosyl-D-lysine/D-serine copolymer. Hisayasu, S., Miyauchi, M., Akiyama, K., Gotoh, T., Satoh, S., Shimada, T. Gene Ther. (1999) [Pubmed]
  21. Separate roles and different routing of calnexin and ERp57 in endoplasmic reticulum quality control revealed by interactions with asialoglycoprotein receptor chains. Frenkel, Z., Shenkman, M., Kondratyev, M., Lederkremer, G.Z. Mol. Biol. Cell (2004) [Pubmed]
  22. Plasma cell membrane glycoprotein PC-1. Primary structure deduced from cDNA clones. van Driel, I.R., Goding, J.W. J. Biol. Chem. (1987) [Pubmed]
  23. Thyroglobulin increases cell proliferation and suppresses Pax-8 in mesangial cells. Sellitti, D.F., Suzuki, K., Doi, S.Q., LaGranha, C., Machado, M., Matos, T., Kohn, L.D. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  24. Effective hepatocyte transplantation using rat hepatocytes with low asialoglycoprotein receptor expression. Ise, H., Nikaido, T., Negishi, N., Sugihara, N., Suzuki, F., Akaike, T., Ikeda, U. Am. J. Pathol. (2004) [Pubmed]
  25. In vivo targeting function of N-linked oligosaccharides with terminating galactose and N-acetylgalactosamine residues. Chiu, M.H., Tamura, T., Wadhwa, M.S., Rice, K.G. J. Biol. Chem. (1994) [Pubmed]
  26. Characterization of the in vitro interaction of PNAhi lymphocytes with the bone marrow and hepatic asialoglycoprotein receptors. Samlowski, W.E., Braaten, B.A., Daynes, R.A. Cell. Immunol. (1985) [Pubmed]
  27. Segmental genomic replacement in embryonic stem cells by double lox targeting. Soukharev, S., Miller, J.L., Sauer, B. Nucleic Acids Res. (1999) [Pubmed]
  28. Prevention of suppression of alloreactive capacity following intravenous injection of neuraminidase-treated allogeneic cells by co-injection of agents competing for asialoglycoprotein receptor. Suda, T., Sano, S., Hori, S., Azuma, T., Tateishi, N., Hamaoka, T., Fujiwara, H. Regional immunology. (1988) [Pubmed]
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