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Gene Review

Asgr1  -  asialoglycoprotein receptor 1

Rattus norvegicus

Synonyms: ASGP-R 1, ASGPR 1, ASGR, Asgr-1, Asialoglycoprotein receptor 1, ...
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Disease relevance of Asgr1


High impact information on Asgr1


Chemical compound and disease context of Asgr1


Biological context of Asgr1


Anatomical context of Asgr1


Associations of Asgr1 with chemical compounds

  • Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence [14].
  • The only proteolytic processing occurring in the biosynthesis of RHL-1 is the removal of the NH2-terminal initiator methionine residue [14].
  • When ASGP-R protein and mRNA levels were measured in animals infused with ethanol or dextrose in the presence of fish oil (FO) or medium-chain triglyceride as the source of fat, more significant impairments to the ASGP-R were observed in the FO-ethanol group compared with the medium-chain triglyceride-ethanol group [1].
  • These results demonstrate that a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content [1].
  • Using quantitative immunoelectron microscopy with colloidal gold, we found that 2 h and 4 h after cycloheximide administration, the densities of ASGP-R and MP-R in the membranes of the Golgi complex were unaltered compared with control liver [21].

Physical interactions of Asgr1


Regulatory relationships of Asgr1


Other interactions of Asgr1


Analytical, diagnostic and therapeutic context of Asgr1


  1. Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats. Casey, C.A., McVicker, B.L., Donohue, T.M., McFarland, M.A., Wiegert, R.L., Nanji, A.A. J. Appl. Physiol. (2004) [Pubmed]
  2. Formation of functional asialoglycoprotein receptor after transfection with cDNAs encoding the receptor proteins. McPhaul, M., Berg, P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Antibodies against the hepatic asialoglycoprotein receptor perfused in situ preferentially attach to periportal liver cells in the rat. McFarlane, B.M., Sipos, J., Gove, C.D., McFarlane, I.G., Williams, R. Hepatology (1990) [Pubmed]
  4. Use of an asialoglycoprotein receptor-targeted magnetic resonance contrast agent to study changes in receptor biology during liver regeneration and endotoxemia in rats. Leveille-Webster, C.R., Rogers, J., Arias, I.M. Hepatology (1996) [Pubmed]
  5. Transcriptional and post-transcriptional regulation of the asialoglycoprotein receptor in normal and neoplastic rat liver. Huber, B.E., Glowinski, I.B., Thorgeirsson, S.S. J. Biol. Chem. (1986) [Pubmed]
  6. Separation of endocytic from exocytic coated vesicles using a novel cholinesterase mediated density shift technique. Helmy, S., Porter-Jordan, K., Dawidowicz, E.A., Pilch, P., Schwartz, A.L., Fine, R.E. Cell (1986) [Pubmed]
  7. Intracellular receptor sorting during endocytosis: comparative immunoelectron microscopy of multiple receptors in rat liver. Geuze, H.J., Slot, J.W., Strous, G.J., Peppard, J., von Figura, K., Hasilik, A., Schwartz, A.L. Cell (1984) [Pubmed]
  8. Intracellular site of asialoglycoprotein receptor-ligand uncoupling: double-label immunoelectron microscopy during receptor-mediated endocytosis. Geuze, H.J., Slot, J.W., Strous, G.J., Lodish, H.F., Schwartz, A.L. Cell (1983) [Pubmed]
  9. Electron microscopic evidence for an asialoglycoprotein receptor on Kupffer cells: localization of lectin-mediated endocytosis. Kolb-Bachofen, V., Schlepper-Schäfer, J., Vogell, W., Kolb, H. Cell (1982) [Pubmed]
  10. Substructural specificity and polyvalent carbohydrate recognition by the Entamoeba histolytica and rat hepatic N-acetylgalactosamine/galactose lectins. Yi, D., Lee, R.T., Longo, P., Boger, E.T., Lee, Y.C., Petri, W.A., Schnaar, R.L. Glycobiology (1998) [Pubmed]
  11. Galactose-specific receptor modulation related to the onset of apoptosis in rat liver. Dini, L., Falasca, L., Lentini, A., Mattioli, P., Piacentini, M., Piredda, L., Autuori, F. Eur. J. Cell Biol. (1993) [Pubmed]
  12. Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding. Kren, B.T., Rodrigues, C.M., Setchell, K.D., Steer, C.J. Am. J. Physiol. (1995) [Pubmed]
  13. Locus of dominant hairless gene (Ht) causing abnormal hair and keratinization maps to rat chromosome 10. Akimoto, T., Suzuki, H., Nakama, K., Suzuki, K. Exp. Anim. (2000) [Pubmed]
  14. Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence. Holland, E.C., Leung, J.O., Drickamer, K. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  15. Hepatocyte adhesion to carbohydrate-derivatized surfaces. I. Surface topography of the rat hepatic lectin. Weisz, O.A., Schnaar, R.L. J. Cell Biol. (1991) [Pubmed]
  16. Isolation of preneoplastic rat liver cells by centrifugal elutriation and binding to asialofetuin. Evarts, R.P., Marsden, E., Hanna, P., Wirth, P.J., Thorgeirsson, S.S. Cancer Res. (1984) [Pubmed]
  17. Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepatic asyaloglycoprotein receptor: cell internalization and animal imaging studies. Prata, M.I., Santos, A.C., Torres, S., Andr??, J.P., Martins, J.A., Neves, M., Garc??a-Mart??n, M.L., Rodrigues, T.B., L??pez-Larrubia, P., Cerd??n, S., Geraldes, C.F. Contrast media & molecular imaging (2006) [Pubmed]
  18. Isolation and expression of cDNA clones for a rat liver asialoglycoprotein receptor. Watts, C. Biosci. Rep. (1986) [Pubmed]
  19. Cellular distribution of the asialoglycoprotein receptor in rat liver. Implications for hepatic accumulation of desialylated lymphocytes. Mizuno, M., Kloppel, T.M., Nakane, P.K., Brown, W.R., Vierling, J.M. Gastroenterology (1984) [Pubmed]
  20. The minor components of the rat asialoglycoprotein receptor are apically located in neonatal enterocytes. Hu, C.B., Lee, E.Y., Hewitt, J.E., Baenziger, J.U., Mu, J.Z., DeSchryver-Kecskemeti, K., Alpers, D.H. Gastroenterology (1991) [Pubmed]
  21. A cycloheximide-resistant pool of receptors for asialoglycoproteins and mannose 6-phosphate residues in the Golgi complex of hepatocytes. Geuze, H.J., Slot, J.W., Strous, G.J., Luzio, J.P., Schwartz, A.L. EMBO J. (1984) [Pubmed]
  22. Differential ligand binding by two subunits of the rat liver asialoglycoprotein receptor. Ruiz, N.I., Drickamer, K. Glycobiology (1996) [Pubmed]
  23. The rat asialoglycoprotein receptor binds the amino-terminal domain of thyroglobulin. Montuori, N., Pacifico, F., Mellone, S., Liguoro, D., Di Jeso, B., Formisano, S., Gentile, F., Consiglio, E. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  24. Identification and analysis of a CA(2+)-dependent lactoferrin receptor in rat liver. Lactoferrin binds to the asialoglycoprotein receptor in a galactose-independent manner. McAbee, D.D., Bennatt, D.J., Ling, Y.Y. Adv. Exp. Med. Biol. (1998) [Pubmed]
  25. Regulation of asialoglycoprotein receptor expression in rat hepatocytes cultured under proliferative conditions. Conti Devirgiliis, L., Massimi, M., Bruscalupi, G., Felici, A., Dini, L. Exp. Cell Res. (1994) [Pubmed]
  26. The RHL-1 subunit of the asialoglycoprotein receptor of thyroid cells: cellular localization and its role in thyroglobulin endocytosis. Pacifico, F., Montuori, N., Mellone, S., Liguoro, D., Ulianich, L., Caleo, A., Troncone, G., Kohn, L.D., Di Jeso, B., Consiglio, E. Mol. Cell. Endocrinol. (2003) [Pubmed]
  27. Ligand-mediated internalization of glucagon receptors in intact rat liver. Authier, F., Desbuquois, B., De Galle, B. Endocrinology (1992) [Pubmed]
  28. c-Met responsiveness of isolated hepatocytes evaluated in an in vitro de-differentiation model. Boost, K.A., Kim, H.J., Engl, T., Oppermann, E., Jonas, D., Oertl, A., Blaheta, R.A. Int. J. Mol. Med. (2006) [Pubmed]
  29. Early disulfide bond formation prevents heterotypic aggregation of membrane proteins in a cell-free translation system. Yilla, M., Doyle, D., Sawyer, J.T. J. Cell Biol. (1992) [Pubmed]
  30. Primary structure of the rat liver asialoglycoprotein receptor. Structural evidence for multiple polypeptide species. Drickamer, K., Mamon, J.F., Binns, G., Leung, J.O. J. Biol. Chem. (1984) [Pubmed]
  31. Exon structure of a mannose-binding protein gene reflects its evolutionary relationship to the asialoglycoprotein receptor and nonfibrillar collagens. Drickamer, K., McCreary, V. J. Biol. Chem. (1987) [Pubmed]
  32. Ultrastructural immunocytochemical localization of the asialoglycoprotein receptor in rat hepatocytes. Mizuno, M., Brown, W.R., Vierling, J.M. Gastroenterology (1984) [Pubmed]
  33. Immunocytochemical localization of the receptor for asialoglycoprotein in rat liver cells. Geuze, H.J., Slot, J.W., Strous, G.J., Lodish, H.F., Schwartz, A.L. J. Cell Biol. (1982) [Pubmed]
  34. Identification of rat testis galactosyl receptor using antibodies to liver asialoglycoprotein receptor: purification and localization on surfaces of spermatogenic cells and sperm. Abdullah, M., Kierszenbaum, A.L. J. Cell Biol. (1989) [Pubmed]
  35. Identification and quantification of the rat hepatocyte asialoglycoprotein receptor. Schwartz, A.L., Marshak-Rothstein, A., Rup, D., Lodish, H.F. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
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