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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Immunoglobulin Class Switching

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Disease relevance of Immunoglobulin Class Switching


High impact information on Immunoglobulin Class Switching


Chemical compound and disease context of Immunoglobulin Class Switching


Biological context of Immunoglobulin Class Switching


Anatomical context of Immunoglobulin Class Switching


Associations of Immunoglobulin Class Switching with chemical compounds


Gene context of Immunoglobulin Class Switching


Analytical, diagnostic and therapeutic context of Immunoglobulin Class Switching


  1. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., Honjo, T. Cell (2000) [Pubmed]
  2. The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching. Rolink, A., Melchers, F., Andersson, J. Immunity (1996) [Pubmed]
  3. Oligoclonal protein bands and Ig isotype switching in multiple myeloma treated with high-dose therapy and hematopoietic cell transplantation. Zent, C.S., Wilson, C.S., Tricot, G., Jagannath, S., Siegel, D., Desikan, K.R., Munshi, N., Bracy, D., Barlogie, B., Butch, A.W. Blood (1998) [Pubmed]
  4. Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies. Elisseeva, O.A., Oka, Y., Tsuboi, A., Ogata, K., Wu, F., Kim, E.H., Soma, T., Tamaki, H., Kawakami, M., Oji, Y., Hosen, N., Kubota, T., Nakagawa, M., Yamagami, T., Hiraoka, A., Tsukaguchi, M., Udaka, K., Ogawa, H., Kishimoto, T., Nomura, T., Sugiyama, H. Blood (2002) [Pubmed]
  5. Impaired class switch recombination (CSR) in Waldenstrom macroglobulinemia (WM) despite apparently normal CSR machinery. Kriangkum, J., Taylor, B.J., Strachan, E., Mant, M.J., Reiman, T., Belch, A.R., Pilarski, L.M. Blood (2006) [Pubmed]
  6. IL-13 effector functions. Wynn, T.A. Annu. Rev. Immunol. (2003) [Pubmed]
  7. A class switch control region at the 3' end of the immunoglobulin heavy chain locus. Cogné, M., Lansford, R., Bottaro, A., Zhang, J., Gorman, J., Young, F., Cheng, H.L., Alt, F.W. Cell (1994) [Pubmed]
  8. Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching. Matsuoka, M., Yoshida, K., Maeda, T., Usuda, S., Sakano, H. Cell (1990) [Pubmed]
  9. Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes. Gerstein, R.M., Frankel, W.N., Hsieh, C.L., Durdik, J.M., Rath, S., Coffin, J.M., Nisonoff, A., Selsing, E. Cell (1990) [Pubmed]
  10. Ig isotype switching in B lymphocytes. The effect of T cell-derived interleukins, cytokines, cholera toxin, and antigen on isotype switch frequency of a cloned B cell lymphoma. Whitmore, A.C., Prowse, D.M., Haughton, G., Arnold, L.W. Int. Immunol. (1991) [Pubmed]
  11. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Chaudhuri, J., Tian, M., Khuong, C., Chua, K., Pinaud, E., Alt, F.W. Nature (2003) [Pubmed]
  12. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., Kikutani, H. Immunity (1994) [Pubmed]
  13. Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Morio, T., Hanissian, S.H., Bacharier, L.B., Teraoka, H., Nonoyama, S., Seki, M., Kondo, J., Nakano, H., Lee, S.K., Geha, R.S., Yata, J. Immunity (1999) [Pubmed]
  14. The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2. Min, I.M., Schrader, C.E., Vardo, J., Luby, T.M., D'Avirro, N., Stavnezer, J., Selsing, E. Immunity (2003) [Pubmed]
  15. Enhancer complexes located downstream of both human immunoglobulin Calpha genes. Mills, F.C., Harindranath, N., Mitchell, M., Max, E.E. J. Exp. Med. (1997) [Pubmed]
  16. Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching. Lutzker, S., Rothman, P., Pollock, R., Coffman, R., Alt, F.W. Cell (1988) [Pubmed]
  17. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Korthäuer, U., Graf, D., Mages, H.W., Brière, F., Padayachee, M., Malcolm, S., Ugazio, A.G., Notarangelo, L.D., Levinsky, R.J., Kroczek, R.A. Nature (1993) [Pubmed]
  18. Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Elzey, B.D., Tian, J., Jensen, R.J., Swanson, A.K., Lees, J.R., Lentz, S.R., Stein, C.S., Nieswandt, B., Wang, Y., Davidson, B.L., Ratliff, T.L. Immunity (2003) [Pubmed]
  19. Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses. Fu, Y.X., Molina, H., Matsumoto, M., Huang, G., Min, J., Chaplin, D.D. J. Exp. Med. (1997) [Pubmed]
  20. Signaling in B cells via Toll-like receptors. Peng, S.L. Curr. Opin. Immunol. (2005) [Pubmed]
  21. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. Fuleihan, R., Ramesh, N., Horner, A., Ahern, D., Belshaw, P.J., Alberg, D.G., Stamenkovic, I., Harmon, W., Geha, R.S. J. Clin. Invest. (1994) [Pubmed]
  22. Role of the complement system in rejection. Sacks, S.H., Chowdhury, P., Zhou, W. Curr. Opin. Immunol. (2003) [Pubmed]
  23. A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon. Zhang, J., Bottaro, A., Li, S., Stewart, V., Alt, F.W. EMBO J. (1993) [Pubmed]
  24. Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. Takhar, P., Smurthwaite, L., Coker, H.A., Fear, D.J., Banfield, G.K., Carr, V.A., Durham, S.R., Gould, H.J. J. Immunol. (2005) [Pubmed]
  25. Gamma 3 gene-disrupted mice selectively deficient in the dominant IgG subclass made to bacterial polysaccharides undergo normal isotype switching after immunization with polysaccharide-protein conjugate vaccines. Shapiro, D.A., Threadgill, D.S., Copfer, M.J., Corey, D.A., McCool, T.L., McCormick, L.L., Magnuson, T.R., Greenspan, N.S., Schreiber, J.R. J. Immunol. (1998) [Pubmed]
  26. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Shimoda, K., van Deursen, J., Sangster, M.Y., Sarawar, S.R., Carson, R.T., Tripp, R.A., Chu, C., Quelle, F.W., Nosaka, T., Vignali, D.A., Doherty, P.C., Grosveld, G., Paul, W.E., Ihle, J.N. Nature (1996) [Pubmed]
  27. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. Wang, Z.E., Reiner, S.L., Zheng, S., Dalton, D.K., Locksley, R.M. J. Exp. Med. (1994) [Pubmed]
  28. Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells. Kimata, H., Fujimoto, M. J. Exp. Med. (1994) [Pubmed]
  29. Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. Schrader, C.E., Vardo, J., Stavnezer, J. J. Exp. Med. (2002) [Pubmed]
  30. Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. Li, Z., Scherer, S.J., Ronai, D., Iglesias-Ussel, M.D., Peled, J.U., Bardwell, P.D., Zhuang, M., Lee, K., Martin, A., Edelmann, W., Scharff, M.D. J. Exp. Med. (2004) [Pubmed]
  31. A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5. Yasue, T., Nishizumi, H., Aizawa, S., Yamamoto, T., Miyake, K., Mizoguchi, C., Uehara, S., Kikuchi, Y., Takatsu, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  32. T-bet regulates IgG class switching and pathogenic autoantibody production. Peng, S.L., Szabo, S.J., Glimcher, L.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  33. Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction. Schmollinger, J.C., Vonderheide, R.H., Hoar, K.M., Maecker, B., Schultze, J.L., Hodi, F.S., Soiffer, R.J., Jung, K., Kuroda, M.J., Letvin, N.L., Greenfield, E.A., Mihm, M., Kutok, J.L., Dranoff, G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  34. Cholera toxin and cholera toxin B subunit induce IgA switching through the action of TGF-beta 1. Kim, P.H., Eckmann, L., Lee, W.J., Han, W., Kagnoff, M.F. J. Immunol. (1998) [Pubmed]
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