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Fgf5  -  fibroblast growth factor 5

Mus musculus

Synonyms: FGF-5, Fgf-5, Fibroblast growth factor 5, HBGF-5, Heparin-binding growth factor 5, ...
 
 
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Disease relevance of Fgf5

 

High impact information on Fgf5

  • Expression of Fgf5 is detected in hair follicles from wild-type mice and is localized to the outer root sheath during the anagen VI phase of the hair growth cycle [5].
  • Mice homozygous for a predicted null allele of the Fgf5 gene, fgf5neo, produced by gene targeting in embryonic stem cells, have abnormally long hair [5].
  • The fgf5neo and go mutations fail to complement one another, and exon 1 of Fgf5 is deleted in DNA from go homozygotes, demonstrating that go is a mutant allele of Fgf5 [5].
  • This phenotype appears identical to that of mice homozygous for the spontaneous mutation angora (go) [5].
  • A cDNA encoding FGFR-1 IIIc was stably transfected into the well-differentiated TAKA-1 pancreatic ductal cell line that is not responsive to FGF5 and does not express FGFR-1 [6].
 

Biological context of Fgf5

  • The Anx3 locus mapped to the middle of mouse chromosome 5 between Areg and Fgf5 [7].
  • This phenotype could be rescued by exogenous FGF-2 but not FGF-5 (10 ng/ml) [8].
  • ORS cells produce fibroblast growth factor-5 (FGF-5), which acts in a paracrine fashion to terminate precursor cell division during anagen [9].
  • The murine gene and the previously isolated human FGF-5 gene are substantially homologous within the coding sequences and in upstream sequences, which contain an additional open reading frame [10].
  • The murine homolog of the fibroblast growth factor-5 (FGF-5) gene has been cloned, and the sequence of the gene's three exons has been determined [10].
 

Anatomical context of Fgf5

  • Detailed mapping of these genes with Oct4, Rex1 and Fgf5 on pregastrulation embryos provided the first molecular evidence for the existence of successive, temporally distinct pluripotent cell populations in the embryo between the ICM and primitive ectoderm [11].
  • The gene was also expressed in the myotomes of the somites, coincident with FGF-4 and FGF-5 transcripts, and was detected transiently in cleaved muscles [12].
  • Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants [8].
  • FGF-2 is apparently the major regulator of GFAP, because in mice deficient for FGF-2, GFAP is distinctly reduced in cortex and striatum, whereas in FGF-5-/- animals only a reduction in the midbrain tegmentum can be observed [8].
  • Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system [10].
 

Associations of Fgf5 with chemical compounds

  • In addition, injection of the muscarinic receptor agonist pilocarpine elevated FGF-5 mRNA [13].
  • In the presence of heparin, recombinant FGF-5 is as active as native growth factor, demonstrating that glycosylation does not significantly potentiate FGF-5 activity [2].
 

Regulatory relationships of Fgf5

  • Our data support the notion that endogenous FGF-2 and FGF-5 regulate GFAP expression in a region-specific manner [8].
 

Other interactions of Fgf5

  • Together, these results demonstrate that N-CAM, tenascin-C, and FGF-5 are dispensable for major aspects of synaptic development and regeneration [14].
  • Chromosomal localizations of mouse Fgf2 and Fgf5 genes [15].
  • Chromosomal localization studies placed the AG1 gene on mouse chromosome 5q21, in tight linkage with Fgf5 [16].
  • Differentiated myofibers express FGF-5, FGF-7, and reduced levels of FGF-6 mRNA [17].
  • We chose to study this particular member of the FGF gene family because we had previously observed that its pattern of expression in cultures of teratocarcinoma cell aggregates is consistent with the proposal that Fgf-5 plays a role in gastrulation in vivo [18].
 

Analytical, diagnostic and therapeutic context of Fgf5

References

  1. Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis. Hébert, J.M., Basilico, C., Goldfarb, M., Haub, O., Martin, G.R. Dev. Biol. (1990) [Pubmed]
  2. Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. Clements, D.A., Wang, J.K., Dionne, C.A., Goldfarb, M. Oncogene (1993) [Pubmed]
  3. Histopathology of melanocytic lesions in goats and establishment of a melanoma cell line: a potential model for human melanoma. Parsons, P.G., Takahashi, H., Candy, J., Meyers, B., Vickers, J., Kelly, W.R., Smith, I., Spradbrow, P. Pigment Cell Res. (1990) [Pubmed]
  4. Messenger ribonucleic acids for fibroblast growth factors and their receptor in bladder and renal cell carcinoma cell lines. Yoshimura, K., Eto, H., Miyake, H., Hara, I., Arakawa, S., Kamidono, S. Cancer Lett. (1996) [Pubmed]
  5. FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Hébert, J.M., Rosenquist, T., Götz, J., Martin, G.R. Cell (1994) [Pubmed]
  6. IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells. Kornmann, M., Ishiwata, T., Matsuda, K., Lopez, M.E., Fukahi, K., Asano, G., Beger, H.G., Korc, M. Gastroenterology (2002) [Pubmed]
  7. Mouse annexin III cDNA, genetic mapping and evolution. Fernández, M.P., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Morgan, R.O. Gene (1998) [Pubmed]
  8. Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. Reuss, B., Dono, R., Unsicker, K. J. Neurosci. (2003) [Pubmed]
  9. Manipulation of outer root sheath cell survival perturbs the hair-growth cycle. Pena, J.C., Kelekar, A., Fuchs, E.V., Thompson, C.B. EMBO J. (1999) [Pubmed]
  10. Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system. Haub, O., Drucker, B., Goldfarb, M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  11. Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. Pelton, T.A., Sharma, S., Schulz, T.C., Rathjen, J., Rathjen, P.D. J. Cell. Sci. (2002) [Pubmed]
  12. FGF-7 (keratinocyte growth factor) expression during mouse development suggests roles in myogenesis, forebrain regionalisation and epithelial-mesenchymal interactions. Mason, I.J., Fuller-Pace, F., Smith, R., Dickson, C. Mech. Dev. (1994) [Pubmed]
  13. Fibroblast growth factor-5 promotes differentiation of cultured rat septal cholinergic and raphe serotonergic neurons: comparison with the effects of neurotrophins. Lindholm, D., Harikka, J., da Penha Berzaghi, M., Castrén, E., Tzimagiorgis, G., Hughes, R.A., Thoenen, H. Eur. J. Neurosci. (1994) [Pubmed]
  14. Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5. Moscoso, L.M., Cremer, H., Sanes, J.R. J. Neurosci. (1998) [Pubmed]
  15. Chromosomal localizations of mouse Fgf2 and Fgf5 genes. Mattei, M.G., Pébusque, M.J., Birnbaum, D. Mamm. Genome (1992) [Pubmed]
  16. In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. George, A., Gui, J., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Veis, A. J. Histochem. Cytochem. (1994) [Pubmed]
  17. Differentially expressed fibroblast growth factors regulate skeletal muscle development through autocrine and paracrine mechanisms. Hannon, K., Kudla, A.J., McAvoy, M.J., Clase, K.L., Olwin, B.B. J. Cell Biol. (1996) [Pubmed]
  18. mRNA localization studies suggest that murine FGF-5 plays a role in gastrulation. Hébert, J.M., Boyle, M., Martin, G.R. Development (1991) [Pubmed]
  19. Fibroblast growth factor-5 is expressed in Schwann cells and is not essential for motoneurone survival. McGeachie, A.B., Koishi, K., Imamura, T., McLennan, I.S. Neuroscience (2001) [Pubmed]
 
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